P26645

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MARCS_MOUSE; P26645;
Entrez ID 17118
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Myristoylated alanine-rich C-kinase substrate (MARCKS)
Gene Name Marcks; Macs
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Sequence
(Fasta)		MGAQFSKTAA KGEATAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA EPGAKEELQA 60
NGSAPAADKE EPASGSAATP AAAEKDEAAA ATEPGAGAAD KEAAEAEPAE PSSPAAEAEG 120
ASASSTSSPK AEDGAAPSPS SETPKKKKKR FSFKKSFKLS GFSFKKSKKE SGEGAEAEGA 180
TAEGAKDEAA AAAGGEGAAA PGEQAGGAGA EGAAGGEPRE AEAAEPEQPE QPEQPAAEEP 240
QAEEQSEAAG EKAEEPAPGA TAGDASSAAG PEQEAPAATD EAAASAAPAA SPEPQPECSP 300
EAPPAPTAE

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaA2040611
[Reference]: No significant stimulation of MARCKS protein phosphorylation was seen in four other insulin-sensitive cell lines, in which insulin is known to activate other protein serine/threonine kinases: HIRC-B, BC3H-1, 3T3-L1 adipocytes, and H35 rat hepatoma cells made to stably express the MARCKS protein.
2Serine PhosphorylationAlzheimer's diseaseUS4627557632
[Reference]: Here, we reveal that phosphorylation of MARCKS, a submembrane protein that regulates the stability of the actin network, occurs at Ser46 prior to aggregation of A? and is sustained throughout the course of AD in human and mouse brains.?
3Serine PhosphorylationMelanomaUS15220211725
[Reference]: PhosphoMARCKS drives motility of mouse melanoma cells.
4Serine PhosphorylationMelanomaUS15620211725
[Reference]: PhosphoMARCKS drives motility of mouse melanoma cells.
5Serine PhosphorylationMelanomaUS16320211725
[Reference]: PhosphoMARCKS drives motility of mouse melanoma cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D001172 ; Arthritis, Rheumatoid
MESH:D003528 ; Carcinoma, Adenoid Cystic
MESH:D012468 ; Salivary Gland Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 32)
(view all)		 112       EAEPAEPSSPAAEAE     dbPAF
113       AEPAEPSSPAAEAEG     dbPAF
122       AAEAEGASASSTSSP     dbPAF
124       EAEGASASSTSSPKA     dbPAF
125       AEGASASSTSSPKAE     dbPAF
126       EGASASSTSSPKAED     dbPAF
Acetylation
(count: 2)		 158       FSFKKSFKLSGFSFK     PLMD
165       KLSGFSFKKSKKESG     PLMD
Ubiquitination
(count: 2)		 11        QFSKTAAKGEATAER     PLMD
158       FSFKKSFKLSGFSFK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource