P26233

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession CTNB_XENLA; P26233;
Entrez ID 399274
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Catenin beta (Beta-catenin)
Gene Name ctnnb1
Organism Xenopus laevis
NCBI Taxa ID 8355
Functional DescriptionKey downstream component of the canonical Wnt signaling pathway. In the presence of Wnt ligand, accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity).;Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Essential component of the vertebrate Wnt-signaling pathway and is required for formation of the embryonic axis.
Sequence
(Fasta)
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEDEDVDTN 60
QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDSAHPT 120
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 180
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 240
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300
LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC SSNKPAIVEA 360
GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 420
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 480
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 540
VRAHQDTQRR TSIGGTQQQF VEGVRMEEIV EGCTGALHIL ARDIHNRIVI RGLNTIPLFV 600
QLLYSPIENI QRVAAGVLCD VAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 660
RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI GAQGEPLGYR QDDSSYRSFH 720
AAGYGQDAMG MDSMMDHDMG GHHPGADYPV DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD 780
L 782

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationMelanomaA10339577
[Reference]: It is well known that serine-phosphorylation of beta-catenin by the Axin-glycogen synthase kinase (GSK)-3beta complex targets beta-catenin for ubiquitination-degradation, and mutations at critical phosphoserine residues stabilize beta-catenin and cause human cancers.
2PhosphorylationMelanomaA10339577
[Reference]: It is well known that serine-phosphorylation of beta-catenin by the Axin-glycogen synthase kinase (GSK)-3beta complex targets beta-catenin for ubiquitination-degradation, and mutations at critical phosphoserine residues stabilize beta-catenin and cause human cancers.
3UbiquitinationColon cancer/carcinomaA10339577
[Reference]: It is well known that serine-phosphorylation of beta-catenin by the Axin-glycogen synthase kinase (GSK)-3beta complex targets beta-catenin for ubiquitination-degradation, and mutations at critical phosphoserine residues stabilize beta-catenin and cause human cancers.
4PhosphorylationColon cancer/carcinomaA10339577
[Reference]: It is well known that serine-phosphorylation of beta-catenin by the Axin-glycogen synthase kinase (GSK)-3beta complex targets beta-catenin for ubiquitination-degradation, and mutations at critical phosphoserine residues stabilize beta-catenin and cause human cancers.


※ PTM Sites

PTM Modification Sites