Tag | Content |
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UniProt Accession | CTNB_XENLA; P26233; |
Entrez ID | 399274 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Catenin beta (Beta-catenin) |
Gene Name | ctnnb1 |
Organism | Xenopus laevis |
NCBI Taxa ID | 8355 |
Functional Description | Key downstream component of the canonical Wnt signaling pathway. In the presence of Wnt ligand, accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity).;Binds to the cytoplasmic domain of the cell-cell adhesion molecule E-cadherin, and perhaps to other (membrane) proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Essential component of the vertebrate Wnt-signaling pathway and is required for formation of the embryonic axis. |
Sequence (Fasta) | MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEDEDVDTN 60 QVLYEWEQGF SQSFTQDQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDSAHPT 120 NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 180 KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 240 VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300 LQILAYGNQE SKLIILASGG PQALVNIMRT YSYEKLLWTT SRVLKVLSVC SSNKPAIVEA 360 GGMQALGLHL TDSSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 420 AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 480 AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 540 VRAHQDTQRR TSIGGTQQQF VEGVRMEEIV EGCTGALHIL ARDIHNRIVI RGLNTIPLFV 600 QLLYSPIENI QRVAAGVLCD VAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 660 RMSEDKPQDY KKRLSVELTS SLFRTEPMPW NEAADLGLDI GAQGEPLGYR QDDSSYRSFH 720 AAGYGQDAMG MDSMMDHDMG GHHPGADYPV DGLPDLSHAQ DLMDGLPPGD SNQLAWFDTD 780 L 782 |
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PTM | Modification Sites |
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