| Tag | Content |
|---|---|
| UniProt Accession | IKBA_HUMAN; P25963; |
| Entrez ID | 4792 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) |
| Gene Name | NFKBIA; IKBA; MAD3; NFKBI |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Sequence (Fasta) | MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ EIRLEPQEVP 60 RGSEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD LAFLNFQNNL QQTPLHLAVI 120 TNQPEIAEAL LGAGCDPELR DFRGNTPLHL ACEQGCLASV GVLTQSCTTP HLHSILKATN 180 YNGHTCLHLA SIHGYLGIVE LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG 240 ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE 300 DELPYDDCVF GGQRLTL 318 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 9) (view all) | MESH:D002545
; Brain Ischemia MESH:D001943 ; Breast Neoplasms MESH:D006528 ; Carcinoma, Hepatocellular MESH:C567411 ; Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant MESH:D006689 ; Hodgkin Disease MESH:D008106 ; Liver Cirrhosis, Experimental |
| HGMD (count: 4) | CM076351; Ectodermal dysplasia, anhidrotic with immune deficiency; Missense/nonsense
CM082966; Ectodermal dysplasia, anhidrotic with immune deficiency; Missense/nonsense CM033654; Ectodermal dysplasia, anhidrotic with immune deficiency; Missense/nonsense CM056013; Hodgkin lymphoma; Missense/nonsense |
| GWASdb (count: 1) | rs696; Psoriasis; psoriasis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 166 SVGVLTQSCTTPHLH dbPAF
283 NLQMLPESEDEESYD dbPAF 288 PESEDEESYDTESEF dbPAF 291 EDEESYDTESEFTEF dbPAF 293 EESYDTESEFTEFTE dbPAF 299 ESEFTEFTEDELPYD dbPAF |
| Ubiquitination (count: 4) | 22 GPRDGLKKERLLDDR PLMD
238 DLVSLLLKCGADVNR PLMD 67 PRGSEPWKQQLTEDG PLMD 87 LAIIHEEKALTMEVI PLMD |
| Sumoylation (count: 2) | 21 EGPRDGLKKERLLDD PLMD
22 GPRDGLKKERLLDDR PLMD |