P25445

※ Protein Information

Tag	Content
UniProt Accession	TNR6_HUMAN; P25445;
Entrez ID	355
GenBank Protein ID	NM_000043.5; NM_001320619.1; NM_152871.3; NM_152872.3;
GenBank Nucleotide ID	NP_000034.1; NP_001307548.1; NP_690610.1; NP_690611.1;
Protein Name	Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene Name	FAS; APT1; FAS1; TNFRSF6
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Functional Description Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Sequence (Fasta)	MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH 60 KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT 120 RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL 180 LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM 240 TLSQVKGFVR KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK 300 ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV 336 Fasta Sequence >P25445\|FAS; APT1; FAS1; TNFRSF6\|Homo sapiens (Human) MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV

※ PTM-Disease Association

Num	PTM	Disease	Type	PMID
1	Phosphorylation	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma	A	14679192
1	[Reference]: Additionally, in CD95-yellow fluorescent protein-transfected Huh7-hepatoma cells, ONOO(-) induced CD95 Tyr nitration and prevented CD95L-induced Tyr phosphorylation and apoptosis.
2	Nitration	Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma	P	14679192
2	[Reference]: Additionally, in CD95-yellow fluorescent protein-transfected Huh7-hepatoma cells, ONOO(-) induced CD95 Tyr nitration and prevented CD95L-induced Tyr phosphorylation and apoptosis.

※ Disease Cross-ref Annotation

Database	Annotation
Cancer Gene Census	TGCT, nasal NK/T lymphoma, skin squamous cell carcinoma-burn scar related
CTD (Curated) (count: 25) (view all)	MESH:D055371 ; Acute Lung Injury MESH:D001327 ; Autoimmune Diseases MESH:D056735 ; Autoimmune Lymphoproliferative Syndrome MESH:D009202 ; Cardiomyopathies MESH:D002311 ; Cardiomyopathy, Dilated MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003924 ; Diabetes Mellitus, Type 2 MESH:D004195 ; Disease Models, Animal MESH:D006402 ; Hematologic Diseases MESH:D006971 ; Hypersplenism MESH:D015470 ; Leukemia, Myeloid, Acute MESH:D017114 ; Liver Failure, Acute MESH:D008175 ; Lung Neoplasms MESH:D016403 ; Lymphoma, Large B-Cell, Diffuse MESH:D016410 ; Lymphoma, T-Cell, Cutaneous MESH:D016778 ; Malaria, Falciparum MESH:D009157 ; Myasthenia Gravis MESH:D009336 ; Necrosis MESH:D009393 ; Nephritis MESH:D065626 ; Non-alcoholic Fatty Liver Disease MESH:D011249 ; Pregnancy Complications, Cardiovascular MESH:D011507 ; Proteinuria MESH:D013651 ; Taste Disorders MESH:D001749 ; Urinary Bladder Neoplasms MESH:D018487 ; Ventricular Dysfunction, Left
DisGeNet (Curated) (count: 114) (view all)	C0000737; Abdominal Pain C0002880; Autoimmune hemolytic anemia C0003635; Apraxias C0003862; Arthralgia C0003864; Arthritis C0004364; Autoimmune Diseases C0004943; Behcet Syndrome C0005695; Bladder Neoplasm C0007193; Cardiomyopathy, Dilated C0009676; Confusion C0011853; Diabetes Mellitus, Experimental C0011860; Diabetes Mellitus, Non-Insulin-Dependent C0014457; Eosinophilia C0015672; Fatigue C0015967; Fever C0017181; Gastrointestinal Hemorrhage C0017601; Glaucoma C0018784; Sensorineural Hearing Loss (disorder) C0018939; Hematological Disease C0018989; Hemiparesis C0019209; Hepatomegaly C0020532; Hypersplenism C0022073; Iridocyclitis C0023467; Leukemia, Myelocytic, Acute C0024121; Lung Neoplasms C0024535; Malaria, Falciparum C0024636; Malocclusion C0025289; Meningitis C0026896; Myasthenia Gravis C0027498; Nausea and vomiting C0027540; Necrosis C0027697; Nephritis C0029191; Orchitis C0032963; Pregnancy Complications, Cardiovascular C0033687; Proteinuria C0035305; Retinal Detachment C0036341; Schizophrenia C0038002; Splenomegaly C0038363; Aphthous Stomatitis C0039338; Taste Disorders C0042109; Urticaria C0042170; Uveomeningoencephalitic Syndrome C0042384; Vasculitis C0042487; Venous Thrombosis C0042798; Low Vision C0042900; Vitiligo C0079744; Diffuse Large B-Cell Lymphoma C0079773; Lymphoma, T-Cell, Cutaneous C0085636; Photophobia C0086543; Cataract C0149745; Oral Ulcer C0149931; Migraine Disorders C0151379; Rheumatoid factor positive (finding) C0151480; Anti-nuclear factor positive C0151632; ESR raised C0151811; Subcutaneous nodule C0152031; Joint swelling C0157917; Pauciarticular juvenile rheumatoid arthritis C0162316; Iron deficiency anemia C0162323; Polyarthritis C0162557; Liver Failure, Acute C0221262; Poliosis C0231528; Myalgia C0237653; Immunologic Hypersensitivity C0239984; Elevated serum IgA C0241054; Skin bulla C0241185; Smooth muscle antibodies positive C0242488; Acute Lung Injury C0242584; Autoimmune thrombocytopenia C0242698; Ventricular Dysfunction, Left C0263498; Premature canities C0332563; Papule C0338656; Impaired cognition C0340971; Autoimmune neutropenia C0349588; Short stature C0398650; Immune thrombocytopenic purpura C0400966; Non-alcoholic Fatty Liver Disease C0520736; Coombs positive hemolytic anemia C0575081; Gait abnormality C0683322; Mental impairment C0702166; Acne C0742906; C-reactive protein increased C0744641; Intermittent migraine headaches C0746926; Multiple, subcutaneous nodules C0878544; Cardiomyopathies C0920163; Idiopathic thrombocytopenia C1328840; Autoimmune Lymphoproliferative Syndrome C1510497; Lens Opacities C1836735; hypopigmented skin patch C1839972; Increased IgM levels C1843386; Reduced delayed hypersensitivity C1857042; Sparse scalp hair C1857108; Decreased joint mobility C1858969; Defective lymphocyte apoptosis C1858970; Chronic noninfectious lymphadenopathy C1858971; Increased number of peripheral CD3+ T cells C1858973; Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors C1858974; Increased proportion of HLA DR+ and CD57+ T cells C1858977; Increased levels of IgG C1858980; Platelet antibody positive C1858981; Neutrophil antibody positive C2132198; Abnormal blistering of the skin C2220104; Blister of skin C2675111; Abnormal eyelashes C2937365; Recurrent aphthous ulcer C3665347; Visual Impairment C3714757; Juvenile rheumatoid arthritis C4011556; Eyebrow abnormalities C4014733; Follicular hyperplasia C4019436; Antiphospholipid antibody positivity C4020887; Photodysphoria C4023452; Elevated C-reactive protein level C4280613; Angle class 3 malocclusion C4280614; Angle class 2 malocclusion
HGMD (count: 73) (view all)	CP995123; Autoimmune lymphoproliferative syndrome; Complex rearrangements CD994528; Autoimmune lymphoproliferative syndrome; Small deletions CD951863; Autoimmune lymphoproliferative syndrome; Small deletions CD991897; Autoimmune lymphoproliferative syndrome; Small deletions CD951864; Autoimmune lymphoproliferative syndrome; Small deletions CD991896; Canale-Smith syndrome; Small deletions CD086580; Autoimmune lymphoproliferative syndrome; Small deletions CD991898; Autoimmune lymphoproliferative syndrome; Small deletions CD085811; Autoimmune lymphoproliferative syndrome; Small deletions CG952367; Autoimmune lymphoproliferative syndrome; Gross deletions CG984479; Autoimmune lymphoproliferative syndrome; Gross deletions CG973542; Autoimmune hepatitis 2; Gross deletions CI962360; Autoimmune lymphoproliferative syndrome; Small insertions CI951979; Autoimmune lymphoproliferative syndrome; Small insertions CI994531; Autoimmune lymphoproliferative syndrome; Small insertions CI004928; Autoimmune lymphoproliferative syndrome; Small insertions CI086579; Autoimmune lymphoproliferative syndrome; Small insertions CI992087; Canale-Smith syndrome; Small insertions CI994530; Autoimmune lymphoproliferative syndrome; Small insertions CM971491; Autoimmune hepatitis 2; Missense/nonsense CM994746; Systemic lupus erythematosus, association with ?; Missense/nonsense CM065176; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM971492; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM994747; Systemic lupus erythematosus, association with ?; Missense/nonsense CM994518; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991185; Canale-Smith syndrome; Missense/nonsense CM065174; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM971493; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM065175; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM045201; Thyroid carcinoma, assoc. with ?; Missense/nonsense CM971494; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991186; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM951215; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM994519; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991187; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991188; Canale-Smith syndrome; Missense/nonsense CM033819; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM961371; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM994520; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM994521; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM971495; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM033041; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM994522; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM085399; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM004283; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM961372; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991189; Canale-Smith syndrome; Missense/nonsense CM981928; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM074788; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM994523; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991190; Canale-Smith syndrome; Missense/nonsense CM994524; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991191; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM951216; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM065173; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM991192; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM033820; Autoimmune lymphoproliferative syndrome; Missense/nonsense CM971496; Autoimmune lymphoproliferative syndrome; Missense/nonsense CR973384; Acute myeloid leukaemia, incr. risk, assoc. with; Regulatory CR024447; Systemic lupus erythematosus, association with; Regulatory CS086576; Autoimmune lymphoproliferative syndrome; Splicing CS982383; Lymphoproliferative disorder; Splicing CS086577; Autoimmune lymphoproliferative syndrome; Splicing CS991510; Autoimmune lymphoproliferative syndrome; Splicing CS033841; Autoimmune lymphoproliferative syndrome; Splicing CS086578; Autoimmune lymphoproliferative syndrome; Splicing CS951537; Autoimmune lymphoproliferative syndrome; Splicing CS043156; Autoimmune lymphoproliferative syndrome; Splicing CS991511; Canale-Smith syndrome; Splicing CS982384; Lymphoproliferative disorder; Splicing CS991512; Autoimmune lymphoproliferative syndrome; Splicing CS994526; Autoimmune lymphoproliferative syndrome; Splicing CS994527; Autoimmune lymphoproliferative syndrome; Splicing
GWASdb (count: 12) (view all)	rs7097572; Lymphocyte counts; asthma\|leukemia\|lymphoma\|lymphopenia\|cardiovascular system disease rs9658691; Total IFN-gamma response to smallpox vaccine; smallpox rs2147420; Chronic lymphocytic leukemia; chronic lymphocytic leukemia rs4406737; Chronic lymphocytic leukemia; chronic lymphocytic leukemia rs7069750; Oligoarticular juvenile idiopathic arthritis; juvenile rheumatoid arthritis rs7069750; Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis; juvenile rheumatoid arthritis rs7069750; Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA); juvenile rheumatoid arthritis rs9658736; LDL cholesterol; atherosclerosis\|coronary artery disease rs9658736; Triglycerides; coronary artery disease\|lipid metabolism disorder\|arteriosclerosis rs982764; Longevity; Null rs982764; Heart Rate; heart conduction disease rs2234978; Immunoglobulin A; selective IgA deficiency disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 18) (view all)	198 KRKEVQKTCRKHRKE dbPAF 209 HRKENQGSHESPTLN dbPAF 212 ENQGSHESPTLNPET dbPAF 214 QGSHESPTLNPETVA dbPAF 219 SPTLNPETVAINLSD dbPAF 225 ETVAINLSDVDLSKY dbPAF 230 NLSDVDLSKYITTIA dbPAF 232 SDVDLSKYITTIAGV dbPAF 234 VDLSKYITTIAGVMT dbPAF 241 TTIAGVMTLSQVKGF dbPAF 243 IAGVMTLSQVKGFVR dbPAF 291 LHGKKEAYDTLIKDL dbPAF 293 GKKEAYDTLIKDLKK dbPAF 305 LKKANLCTLAEKIQT dbPAF 322 LKDITSDSENSNFRN dbPAF 325 ITSDSENSNFRNEIQ dbPAF 333 NFRNEIQSLV***** dbPAF 91 PCQEGKEYTDKAHFS dbPAF
Acetylation (count: 1)	299 DTLIKDLKKANLCTL PLMD
Ubiquitination (count: 4)	263 EAKIDEIKNDNVQDT PLMD 288 WHQLHGKKEAYDTLI PLMD 309 NLCTLAEKIQTIILK PLMD 316 KIQTIILKDITSDSE PLMD
Glycation (count: 1)	193 LIVWVKRKEVQKTCR PLMD
Malonylation (count: 2)	299 DTLIKDLKKANLCTL PLMD 300 TLIKDLKKANLCTLA PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

G3V0F8	P25445	HPRD
O14727	P25445	HPRD
O15273	P25445	IntAct
O15519	P25445	IntAct
O75340	P25445	HPRD; IntAct
O75888	P25445	HPRD
O95243	P25445	IntAct
P00533	P25445	HPRD
P06239	P25445	HPRD; DIP
P06241	P25445	HPRD
P07910	P25445	IntAct
P07947	P25445	IntAct
P08581	P25445	HPRD
P12931	P25445	DIP; IntAct
P15311	P25445	HPRD
P17252	P25445	HPRD
P19174	P25445	DIP
P24522	P25445	IntAct
P25445	P25445	HPRD; DIP; IntAct
P25445	P29590	IntAct
P25445	P30281	IntAct
P25445	P41226	HPRD
P25445	P46379	IntAct
P25445	P48023	HPRD; DIP; IntAct
P25445	P62158	HPRD; IntAct
P25445	P62834	HPRD
P25445	P63165	HPRD; IntAct
P25445	P63279	HPRD
P25445	P68104	HPRD; IntAct
P25445	Q03135	IntAct
P25445	Q06187	HPRD
P25445	Q08722	HPRD
P25445	Q12923	IntAct; MINT;HPRD
P25445	Q12955	HPRD
P25445	Q13158	HPRD; DIP; IntAct; MINT
P25445	Q13546	HPRD; DIP; IntAct
P25445	Q14194	IntAct;HPRD
P25445	Q14790	IntAct;HPRD; IntAct; MINT
P25445	Q15156	IntAct
P25445	Q15628	HPRD
P25445	Q5T3J3	HPRD
P25445	Q5UIP0	IntAct
P25445	Q6Q788	IntAct
P25445	Q8TES7	HPRD
P25445	Q92851	IntAct
P25445	Q99437	IntAct
P25445	Q99683	IntAct
P25445	Q9BWQ8	HPRD
P25445	Q9H3N1	IntAct
P25445	Q9H422	HPRD
P25445	Q9UER7	HPRD; DIP; IntAct
P25445	Q9UK73	HPRD
P25445	Q9UKL3	HPRD
P25445	Q9UKR5	HPRD; IntAct
P25445	Q9UMX0	IntAct
P25445	Q9UNN5	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction