Tag | Content |
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UniProt Accession | CDK2_HUMAN; P24941; |
Entrez ID | 1017 |
GenBank Protein ID | NM_001290230.1; NM_001798.4; NM_052827.3; |
GenBank Nucleotide ID | NP_001277159.1; NP_001789.2; NP_439892.2; |
Protein Name | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) |
Gene Name | CDK2; CDKN2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation (view all) |
Sequence (Fasta) | MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60 PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS 120 HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY 180 STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF 240 PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL 299 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D008545 ; Melanoma |
DisGeNet (Curated) (count: 1) | C0025202; melanoma |
GWASdb (count: 6) | rs2069408; Multiple complex diseases; Null
rs2069408; Asthma; asthma rs2069408; White matter integrity; bipolar disorder|brain disease rs2069408; Polycystic ovary syndrome; polycystic ovary syndrome rs2069415; Asthma; asthma rs1045435; Pulmonary function; asthma|chronic obstructive pulmonary disease |
PTM | Modification Sites |
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Phosphorylation (count: 15) (view all) | 137 PQNLLINTEGAIKLA dbPAF
14 VEKIGEGTYGVVYKA dbPAF 15 EKIGEGTYGVVYKAR dbPAF 158 AFGVPVRTYTHEVVT dbPAF 159 FGVPVRTYTHEVVTL dbPAF 160 GVPVRTYTHEVVTLW dbPAF |
Acetylation (count: 7) (view all) | 20 GTYGVVYKARNKLTG PLMD
24 VVYKARNKLTGEVVA PLMD 278 PNKRISAKAALAHPF PLMD 291 PFFQDVTKPVPHLRL PLMD 33 TGEVVALKKIRLDTE PLMD 6 **MENFQKVEKIGEG PLMD |
Ubiquitination (count: 14) (view all) | 129 RVLHRDLKPQNLLIN PLMD
142 INTEGAIKLADFGLA PLMD 20 GTYGVVYKARNKLTG PLMD 237 VTSMPDYKPSFPKWA PLMD 24 VVYKARNKLTGEVVA PLMD 242 DYKPSFPKWARQDFS PLMD |
Sumoylation (count: 2) | 33 TGEVVALKKIRLDTE PLMD
6 **MENFQKVEKIGEG PLMD |
Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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