P24752

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession THIL_HUMAN; P24752;
Entrez ID 38
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)
Gene Name ACAT1; ACAT; MAT
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPlays a major role in ketone body metabolism.
Sequence
(Fasta)		MAVLAALLRS GARSRSPLLR RLVQEIRYVE RSYVSKPTLK EVVIVSATRT PIGSFLGSLS 60
LLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG QAPTRQAVLG AGLPISTPCT 120
TINKVCASGM KAIMMASQSL MCGHQDVMVA GGMESMSNVP YVMNRGSTPY GGVKLEDLIV 180
KDGLTDVYNK IHMGSCAENT AKKLNIARNE QDAYAINSYT RSKAAWEAGK FGNEVIPVTV 240
TVKGQPDVVV KEDEEYKRVD FSKVPKLKTV FQKENGTVTA ANASTLNDGA AALVLMTADA 300
AKRLNVTPLA RIVAFADAAV EPIDFPIAPV YAASMVLKDV GLKKEDIAMW EVNEAFSLVV 360
LANIKMLEID PQKVNINGGA VSLGHPIGMS GARIVGHLTH ALKQGEYGLA SICNGGGGAS 420
AMLIQKL 428

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationLeukemiaUY40727867011
[Reference]: We found that active, tetrameric ACAT1 is commonly upregulated in cells stimulated by EGF and in diverse human cancer cells, where ACAT1 tetramers, but not monomers, are phosphorylated and stabilized by enhanced Y407 phosphorylation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:C535434 ; Beta ketothiolase deficiency
MESH:D007676 ; Kidney Failure, Chronic
MESH:D008106 ; Liver Cirrhosis, Experimental
MESH:D012640 ; Seizures
DisGeNet (Curated)
(count: 14)
(view all)		C0011175; Dehydration
C0022661; Kidney Failure, Chronic
C0023893; Liver Cirrhosis, Experimental
C0025362; Mental Retardation
C0036572; Seizures
C0042963; Vomiting
GWASdb
(count: 1)		rs10890819; Stroke; cerebrovascular disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 12)
(view all)		 116       LGAGLPISTPCTTIN     dbPAF
128       TINKVCASGMKAIMM     dbPAF
137       MKAIMMASQSLMCGH     dbPAF
214       ARNEQDAYAINSYTR     dbPAF
219       DAYAINSYTRSKAAW     dbPAF
220       AYAINSYTRSKAAWE     dbPAF
Acetylation
(count: 18)
(view all)		 124       TPCTTINKVCASGMK     PLMD
174       STPYGGVKLEDLIVK     PLMD
181       KLEDLIVKDGLTDVY     PLMD
190       GLTDVYNKIHMGSCA     PLMD
202       SCAENTAKKLNIARN     PLMD
230       KAAWEAGKFGNEVIP     PLMD
Ubiquitination
(count: 6)		 174       STPYGGVKLEDLIVK     PLMD
181       KLEDLIVKDGLTDVY     PLMD
230       KAAWEAGKFGNEVIP     PLMD
263       YKRVDFSKVPKLKTV     PLMD
302       LMTADAAKRLNVTPL     PLMD
87        GIPKEEVKEAYMGNV     PLMD
Glycation
(count: 1)		 78        AIQGAIEKAGIPKEE     PLMD
Malonylation
(count: 7)
(view all)		 174       STPYGGVKLEDLIVK     PLMD
190       GLTDVYNKIHMGSCA     PLMD
243       IPVTVTVKGQPDVVV     PLMD
251       GQPDVVVKEDEEYKR     PLMD
263       YKRVDFSKVPKLKTV     PLMD
268       FSKVPKLKTVFQKEN     PLMD
Succinylation
(count: 8)
(view all)		 174       STPYGGVKLEDLIVK     PLMD
202       SCAENTAKKLNIARN     PLMD
243       IPVTVTVKGQPDVVV     PLMD
251       GQPDVVVKEDEEYKR     PLMD
263       YKRVDFSKVPKLKTV     PLMD
268       FSKVPKLKTVFQKEN     PLMD