Tag | Content |
---|---|
UniProt Accession | MDM2_MOUSE; P23804; |
Entrez ID | 17246 |
GenBank Protein ID | NM_001288586.2; NM_010786.4; |
GenBank Nucleotide ID | NP_001275515.1; NP_034916.1; |
Protein Name | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) |
Gene Name | Mdm2 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100, PubMed:21804542). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219). Permits the nuclear export of p53/TP53 (By similarity). Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity). Inhibits(view all) |
Sequence (Fasta) | MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM KEIIFYIGQY 60 IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVAV SQQDSGTSLS 120 ESRRQPEGGS DLKDPLQAPP EEKPSSSDLI SRLSTSSRRR SISETEENTD ELPGERHRKR 180 RRSLSFDPSL GLCELREMCS GGSSSSSSSS SESTETPSHQ DLDDGVSEHS GDCLDQDSVS 240 DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ TGESDTDSFE GDPEISLADY 300 WKCTSCNEMN PPLPSHCKRC WTLRENWLPD DKGKDKVEIS EKAKLENSAQ AEEGLDVPDG 360 KKLTENDAKE PCAEEDSEEK AEQTPLSQES DDYSQPSTSS SIVYSSQESV KELKEETQDK 420 DESVESSFSL NAIEPCVICQ GRPKNGCIVH GKTGHLMSCF TCAKKLKKRN KPCPVCRQPI 480 QMIVLTYFN |
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Database | Annotation |
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CTD (Curated) (count: 8) (view all) | MESH:D001943
; Breast Neoplasms MESH:D002471 ; Cell Transformation, Neoplastic MESH:D015658 ; HIV Infections MESH:D007248 ; Infertility, Male MESH:D008545 ; Melanoma MESH:D002289 ; Carcinoma, Non-Small-Cell Lung |
PTM | Modification Sites |
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Phosphorylation (count: 15) (view all) | 161 STSSRRRSISETEEN dbPAF
163 SSRRRSISETEENTD dbPAF 165 RRRSISETEENTDEL dbPAF 183 RHRKRRRSLSFDPSL dbPAF 185 RKRRRSLSFDPSLGL dbPAF 216 SSSESTETPSHQDLD dbPAF |
Network | Interaction | ||
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A | B | Source | |