Tag | Content |
---|---|
UniProt Accession | IF4B_HUMAN; P23588; |
Entrez ID | 1975 |
GenBank Protein ID | NM_001330654.1; NM_001417.6; |
GenBank Nucleotide ID | NP_001317583.1; NP_001408.2; |
Protein Name | Eukaryotic translation initiation factor 4B (eIF-4B) |
Gene Name | EIF4B |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
Sequence (Fasta) | MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 60 DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 120 ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 180 DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 240 YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 300 RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 360 FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 420 GSESSQTGTS TTSSRNARRR ESEKSLENET LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK 480 ENAWVKRSSN PPARSQSSDT EQQSPTSGGG KVAPAQPSEE GPGRKDENKV DGMNAPKGQT 540 GNSSRGPGDG GNRDHWKESD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG 600 EDENEGEDYA E 612 |
|
Database | Annotation |
---|---|
DisGeNet (Curated) (count: 2) | C0041696; Unipolar Depression
C1269683; Major Depressive Disorder |
GWASdb (count: 2) | rs10506315; Cognitive test performance; cognitive disorder
rs4919697; Multiple complex diseases; Null |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 105) (view all) | 105 AFLGNLPYDVTEESI dbPAF
111 PYDVTEESIKEFFRG dbPAF 131 VRLPREPSNPERLKG dbPAF 14 KKNKKGKTISLTDFL dbPAF 141 ERLKGFGYAEFEDLD dbPAF 155 DSLLSALSLNEESLG dbPAF |
Acetylation (count: 14) (view all) | 177 VADQAQDKDRDDRSF PLMD
194 DRNRDSDKTDTDWRA PLMD 223 GDDSFGDKYRDRYDS PLMD 337 QRPKLNLKPRSTPKE PLMD 365 ASIFGGAKPVDTAAR PLMD 444 ARRRESEKSLENETL PLMD |
Ubiquitination (count: 12) (view all) | 177 VADQAQDKDRDDRSF PLMD
223 GDDSFGDKYRDRYDS PLMD 343 LKPRSTPKEDDSSAS PLMD 365 ASIFGGAKPVDTAAR PLMD 386 RLQKEQEKLQRQLDE PLMD 395 QRQLDEPKLERRPRE PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |