P23588

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession IF4B_HUMAN; P23588;
Entrez ID 1975
GenBank Protein ID NM_001330654.1; NM_001417.6;
GenBank Nucleotide ID NP_001317583.1; NP_001408.2;
Protein Name Eukaryotic translation initiation factor 4B (eIF-4B)
Gene Name EIF4B
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRequired for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Sequence
(Fasta)
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 60
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 120
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 180
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 240
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 300
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 360
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 420
GSESSQTGTS TTSSRNARRR ESEKSLENET LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK 480
ENAWVKRSSN PPARSQSSDT EQQSPTSGGG KVAPAQPSEE GPGRKDENKV DGMNAPKGQT 540
GNSSRGPGDG GNRDHWKESD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG 600
EDENEGEDYA E 612

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationProstate cancer/carcinoma/adenocarcinomaU23813671
[Reference]: The higher Pim-2 expressed, the more eIF4B phosphorylated, then the less cell got apoptosis, and vice versa

※ Disease Cross-ref Annotation

DatabaseAnnotation
DisGeNet (Curated)
(count: 2)
C0041696; Unipolar Depression
C1269683; Major Depressive Disorder
GWASdb
(count: 2)
rs10506315; Cognitive test performance; cognitive disorder
rs4919697; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 105)
(view all)
105       AFLGNLPYDVTEESI     dbPAF
111       PYDVTEESIKEFFRG     dbPAF
131       VRLPREPSNPERLKG     dbPAF
14        KKNKKGKTISLTDFL     dbPAF
141       ERLKGFGYAEFEDLD     dbPAF
155       DSLLSALSLNEESLG     dbPAF
Acetylation
(count: 14)
(view all)
177       VADQAQDKDRDDRSF     PLMD
194       DRNRDSDKTDTDWRA     PLMD
223       GDDSFGDKYRDRYDS     PLMD
337       QRPKLNLKPRSTPKE     PLMD
365       ASIFGGAKPVDTAAR     PLMD
444       ARRRESEKSLENETL     PLMD
Ubiquitination
(count: 12)
(view all)
177       VADQAQDKDRDDRSF     PLMD
223       GDDSFGDKYRDRYDS     PLMD
343       LKPRSTPKEDDSSAS     PLMD
365       ASIFGGAKPVDTAAR     PLMD
386       RLQKEQEKLQRQLDE     PLMD
395       QRQLDEPKLERRPRE     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource