P23560

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	BDNF_HUMAN; P23560;
Entrez ID	627
GenBank Protein ID	NM_001143805.1; NM_001143806.1; NM_001143807.1; NM_001143808.1; NM_001143809.1; NM_001143810.1; NM_001143811.1; NM_001143812.1; NM_001143813.1; NM_001143814.1; NM_001143816.1; NM_001709.4; NM_170731.4; NM_170732.4; NM_170733.3; NM_170734.3; NM_170735.5; XM_011520280.2;
GenBank Nucleotide ID	NP_001137277.1; NP_001137278.1; NP_001137279.1; NP_001137280.1; NP_001137281.1; NP_001137282.1; NP_001137283.1; NP_001137284.1; NP_001137285.1; NP_001137286.1; NP_001137288.1; NP_001700.2; NP_733927.1; NP_733928.1; NP_733929.1; NP_733930.1; NP_733931.1; XP_011518582.1;
Protein Name	Brain-derived neurotrophic factor (BDNF) (Abrineurin)
Gene Name	BDNF
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Functional Description During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Sequence (Fasta)	MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA 60 DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA 120 NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY 180 FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT 240 LTIKRGR 248 Fasta Sequence >P23560\|BDNF\|Homo sapiens (Human) MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Palmitoylation	Huntington's disease		D		24347167
1	[Reference]: We found that HTT overexpression resulted in a palmitoylation- and BDNF-dependent increase in PSD-95 clustering at synaptic sites in striatal spiny projection neurons (SPNs) co-cultured with cortical neurons. Surprisingly, the latter effect was mediated presynaptically, as HTT overexpression in cortical neurons alone was sufficient to increase PSD-95 clustering in the postsynaptic SPNs.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 33) (view all)	MESH:D000544 ; Alzheimer Disease MESH:D019969 ; Amphetamine-Related Disorders MESH:D000067877 ; Autism Spectrum Disorder MESH:D001321 ; Autistic Disorder MESH:D001714 ; Bipolar Disorder MESH:D001835 ; Body Weight MESH:D001930 ; Brain Injuries MESH:D002545 ; Brain Ischemia MESH:D052018 ; Bulimia Nervosa MESH:D019970 ; Cocaine-Related Disorders MESH:C536209 ; Congenital central hypoventilation syndrome MESH:D003638 ; Deafness MESH:D003866 ; Depressive Disorder MESH:D004827 ; Epilepsy MESH:D004830 ; Epilepsy, Tonic-Clonic MESH:D005911 ; Gliosis MESH:D006556 ; Heroin Dependence MESH:D000860 ; Hypoxia MESH:D007249 ; Inflammation MESH:D008607 ; Intellectual Disability MESH:D009410 ; Nerve Degeneration MESH:D009422 ; Nervous System Diseases MESH:D013226 ; Status Epilepticus MESH:D009767 ; Obesity, Morbid MESH:D009771 ; Obsessive-Compulsive Disorder MESH:D010300 ; Parkinson Disease MESH:D011618 ; Psychotic Disorders MESH:D012559 ; Schizophrenia MESH:D012640 ; Seizures MESH:D013274 ; Stomach Neoplasms MESH:D013375 ; Substance Withdrawal Syndrome OMIM:188890 ; TOBACCO ADDICTION, SUSCEPTIBILITY TO MESH:D014029 ; Tobacco Use Disorder
HGMD (count: 9) (view all)	CE068220; Bipolar disorder, susceptibility, association with; Repeat variations CP068169; Bipolar disorder, association with; Complex rearrangements CP066519; Hyperphagia and severe obesity; Complex rearrangements CM023769; Central hypoventilation syndrome ?; Missense/nonsense CM020369; Parkinson disease, association with; Missense/nonsense CR014434; Alzheimer disease, association with; Regulatory CR057851; Reduced promoter activity, association with; Regulatory CS071152; Alzheimer disease in APOE4 non-carriers, assoc.; Splicing CS071153; Alzheimer disease in APOE4 non-carriers, assoc.; Splicing
GWASdb (count: 19) (view all)	rs6265; Weight; obesity rs6265; Body mass index; obesity rs6265; Smoking behavior; nicotine dependence\|lung cancer rs6265; Eating disorders; eating disorder rs11030101; Bone mineral density (paediatric, skull); bone resorption disease rs11030104; Body mass index; obesity rs1401635; Body mass index; obesity rs12291186; HIV-1 control; Human immunodeficiency virus infectious disease rs7103873; Bone mineral density (paediatric, skull); bone resorption disease rs10835211; Smoking behavior; nicotine dependence\|lung cancer rs10835211; Obesity; obesity rs6484320; Smoking behavior; nicotine dependence\|lung cancer rs2049046; Bone mineral density (paediatric, skull); bone resorption disease rs10767664; Body mass index; obesity rs10767664; Body mass index (males); obesity rs10767664; Body mass index (females); obesity rs2030323; Body mass index; obesity rs2030323; Obesity; obesity rs12273363; Amyotrophic lateral sclerosis (sporadic); amyotrophic lateral sclerosis

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 6)	11 LFLTMVISYFGCMKA dbPAF 12 FLTMVISYFGCMKAA dbPAF 155 VTAADKKTAVDMSGG dbPAF 191 TKCNPMGYTKEGCRG dbPAF 62 GLTSLADTFEHVIEE dbPAF 7 *MTILFLTMVISYFG dbPAF

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P03372	P23560	HPRD
P23560	P29474	HPRD