| Tag | Content |
|---|---|
| UniProt Accession | JAK1_HUMAN; P23458; |
| Entrez ID | 3716 |
| GenBank Protein ID | NM_001320923.1; NM_001321852.1; NM_001321853.1; NM_001321854.1; NM_001321855.1; NM_001321856.1; NM_002227.3; |
| GenBank Nucleotide ID | NP_001307852.1; NP_001308781.1; NP_001308782.1; NP_001308783.1; NP_001308784.1; NP_001308785.1; NP_002218.2; |
| Protein Name | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) |
| Gene Name | JAK1; JAK1A; JAK1B |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). |
| Sequence (Fasta) | MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 60 CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 120 DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180 DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240 NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300 WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH KKDEEKNKIR 360 EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420 HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480 CFEKSEQVQG AQKQFKNFQI EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML 540 KRCCQPKPRE ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG 600 TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI VYLYGVCVRD 660 VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS ALSYLEDKDL VHGNVCTKNL 720 LLAREGIDSE CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG 780 TTLWEICYNG EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA 840 IMRDINKLEE QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 900 TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP 960 SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG 1020 DFGLTKAIET DKEYYTVKDD RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS 1080 DSSPMALFLK MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT 1140 SFQNLIEGFE ALLK 1155 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | ALL |
| GWASdb (count: 8) (view all) | rs12353950; Type 2 diabetes; type 2 diabetes mellitus
rs17390055; Type 2 diabetes; type 2 diabetes mellitus rs4916005; Suicide attempts in bipolar disorder; bipolar disorder rs10789166; Suicide attempts in bipolar disorder; bipolar disorder rs12093269; Suicide attempts in bipolar disorder; bipolar disorder rs3818753; LDL cholesterol; atherosclerosis|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 32) (view all) | 1025 KIGDFGLTKAIETDK dbPAF
1030 GLTKAIETDKEYYTV dbPAF 1034 AIETDKEYYTVKDDR dbPAF 1035 IETDKEYYTVKDDRD dbPAF 1036 ETDKEYYTVKDDRDS dbPAF 1043 TVKDDRDSPVFWYAP dbPAF |
| Acetylation (count: 1) | 267 SVSTHDLKVKYLATL PLMD |
| Ubiquitination (count: 39) (view all) | 100 RTITVDDKMSLRLHY PLMD
1032 TKAIETDKEYYTVKD PLMD 1109 TRLVNTLKEGKRLPC PLMD 1130 EVYQLMRKCWEFQPS PLMD 141 QKNGYEKKKIPDATP PLMD 142 KNGYEKKKIPDATPL PLMD |