Tag | Content |
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UniProt Accession | KS6B1_HUMAN; P23443; |
Entrez ID | 6198 |
GenBank Protein ID | NM_001272042.1; NM_001272043.1; NM_001272044.1; NM_001272060.1; NM_003161.3; |
GenBank Nucleotide ID | NP_001258971.1; NP_001258972.1; NP_001258973.1; NP_001258989.1; NP_003152.1; |
Protein Name | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) ( |
Gene Name | RPS6KB1; STK14A |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex (view all) |
Sequence (Fasta) | MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG 60 PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF 120 AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL 180 FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC 240 KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK 300 TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL 360 LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE 420 SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG 480 IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL 526 |
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Database | Annotation |
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CTD (Curated) (count: 5) | MESH:D001284
; Atrophy MESH:C537948 ; Ceroid lipofuscinosis, neuronal 1, infantile MESH:D006973 ; Hypertension MESH:D017379 ; Hypertrophy, Left Ventricular MESH:D016403 ; Lymphoma, Large B-Cell, Diffuse |
HGMD (count: 2) | CD072467; Protein kinase deficiency; Small deletions
CD072468; Protein kinase deficiency; Small deletions |
GWASdb (count: 5) | rs2526354; Multiple complex diseases; Null
rs2526354; Arthritis (juvenile idiopathic); juvenile rheumatoid arthritis rs2531899; Obesity-related traits; obesity rs180515; Multiple sclerosis; multiple sclerosis rs1051424; Obesity-related traits; obesity |
PTM | Modification Sites |
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Phosphorylation (count: 25) (view all) | 235 HQGHVKLTDFGLCKE dbPAF
243 DFGLCKESIHDGTVT dbPAF 248 KESIHDGTVTHTFCG dbPAF 250 SIHDGTVTHTFCGTI dbPAF 252 HDGTVTHTFCGTIEY dbPAF 256 VTHTFCGTIEYMAPE dbPAF |
Acetylation (count: 2) | 304 NRKKTIDKILKCKLN PLMD
516 QAFPMISKRPEHLRM PLMD |
Ubiquitination (count: 4) | 104 LGKGGYGKVFQVRKV PLMD
135 AMIVRNAKDTAHTKA PLMD 450 RTPVSPVKFSPGDFW PLMD 99 ELLRVLGKGGYGKVF PLMD |
Malonylation (count: 1) | 304 NRKKTIDKILKCKLN PLMD |
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