Tag | Content |
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UniProt Accession | RS3_HUMAN; P23396; |
Entrez ID | 6188 |
GenBank Protein ID | NM_001005.4; NM_001256802.1; NM_001260506.1; NM_001260507.1; |
GenBank Nucleotide ID | NP_000996.2; NP_001243731.1; NP_001247435.1; NP_001247436.1; |
Protein Name | 40S ribosomal protein S3 (EC 4.2.99.18) (Small ribosomal subunit protein uS3) |
Gene Name | RPS3; OK/SW-cl.26 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to inta(view all) |
Sequence (Fasta) | MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG 60 EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY 120 GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG 180 VLGIKVKIML PWDPTGKIGP KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV 240 PTA 244 |
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Database | Annotation |
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CTD (Curated) (count: 2) | MESH:D043171
; Chromosomal Instability MESH:D008545 ; Melanoma |
GWASdb (count: 3) | rs3094303; Multiple complex diseases; Null
rs3094303; Urinary metabolites; kidney disease rs4348932; Acute lymphoblastic leukemia (childhood); acute lymphocytic leukemia|acute leukemia |
PTM | Modification Sites |
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Phosphorylation (count: 18) (view all) | 104 CAIAQAESLRYKLLG dbPAF
107 AQAESLRYKLLGGLA dbPAF 120 LAVRRACYGVLRFIM dbPAF 139 KGCEVVVSGKLRGQR dbPAF 166 HSGDPVNYYVDTAVR dbPAF 167 SGDPVNYYVDTAVRH dbPAF |
Acetylation (count: 16) (view all) | 10 VQISKKRKFVADGIF PLMD
108 QAESLRYKLLGGLAV PLMD 132 FIMESGAKGCEVVVS PLMD 141 CEVVVSGKLRGQRAK PLMD 151 GQRAKSMKFVDGLMI PLMD 18 FVADGIFKAELNEFL PLMD |
Ubiquitination (count: 20) (view all) | 10 VQISKKRKFVADGIF PLMD
108 QAESLRYKLLGGLAV PLMD 132 FIMESGAKGCEVVVS PLMD 141 CEVVVSGKLRGQRAK PLMD 148 KLRGQRAKSMKFVDG PLMD 151 GQRAKSMKFVDGLMI PLMD |
Sumoylation (count: 5) | 141 CEVVVSGKLRGQRAK PLMD
18 FVADGIFKAELNEFL PLMD 214 HVSIVEPKDEILPTT PLMD 230 ISEQKGGKPEPPAMP PLMD 62 TQNVLGEKGRRIREL PLMD |
Malonylation (count: 5) | 108 QAESLRYKLLGGLAV PLMD
202 TGKIGPKKPLPDHVS PLMD 214 HVSIVEPKDEILPTT PLMD 62 TQNVLGEKGRRIREL PLMD 90 SVELYAEKVATRGLC PLMD |
Succinylation (count: 1) | 62 TQNVLGEKGRRIREL PLMD |
Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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