P22626

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ROA2_HUMAN; P22626;
Entrez ID 3181
GenBank Protein ID NM_002137.3; NM_031243.2; XM_005249729.1; XM_017012109.1; XM_017012110.1;
GenBank Nucleotide ID NP_002128.1; NP_112533.1; XP_005249786.1; XP_016867598.1; XP_016867599.1;
Protein Name Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene Name HNRNPA2B1; HNRPA2B1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionHeterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different (view all)
Sequence
(Fasta)
MEKTLETVPL ERKKREKEQF RKLFIGGLSF ETTEESLRNY YEQWGKLTDC VVMRDPASKR 60
SRGFGFVTFS SMAEVDAAMA ARPHSIDGRV VEPKRAVARE ESGKPGAHVT VKKLFVGGIK 120
EDTEEHHLRD YFEEYGKIDT IEIITDRQSG KKRGFGFVTF DDHDPVDKIV LQKYHTINGH 180
NAEVRKALSR QEMQEVQSSR SGRGGNFGFG DSRGGGGNFG PGPGSNFRGG SDGYGSGRGF 240
GDGYNGYGGG PGGGNFGGSP GYGGGRGGYG GGGPGYGNQG GGYGGGYDNY GGGNYGSGNY 300
NDFGNYNQQP SNYGPMKSGN FGGSRNMGGP YGGGNYGPGG SGGSGGYGGR SRY 354

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Lysine MethylationAcute myeloid leukaemia/Acute myelogenous leukemiaPR15316732326
[Reference]: Further, we analysed 42 MS spectra representative of hnRNPH1, calreticulin and hnRNPA2/B1 in a peak explorer, which reveals a cytogenetic-specific PTM of b- O-linked N-acetyl glucosamine ( O-GlcNAc) of hnRNPH1 in AML patients with11q23 translocation, an acetylation of calreticulin in t(8;21) translocation and methylation of hnRNPA2/B1 in patients with translocations of t(8;21) and inv(16)

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
prostate
CTD (Curated)
(count: 2)
MESH:C563476 ; Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell
DisGeNet (Curated)
(count: 18)
(view all)
C0023493; Adult T-Cell Lymphoma/Leukemia
C0026848; Myopathy
C0026850; Muscular Dystrophy
C0027121; Myositis
C0151576; Elevated creatine kinase
C0233514; Abnormal behavior

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 49)
(view all)
102       RAVAREESGKPGAHV     dbPAF
131       EEHHLRDYFEEYGKI     dbPAF
135       LRDYFEEYGKIDTIE     dbPAF
140       EEYGKIDTIEIITDR     dbPAF
145       IDTIEIITDRQSGKK     dbPAF
149       EIITDRQSGKKRGFG     dbPAF
Acetylation
(count: 11)
(view all)
104       VAREESGKPGAHVTV     PLMD
112       PGAHVTVKKLFVGGI     PLMD
113       GAHVTVKKLFVGGIK     PLMD
120       KLFVGGIKEDTEEHH     PLMD
168       DDHDPVDKIVLQKYH     PLMD
17        LERKKREKEQFRKLF     PLMD
Ubiquitination
(count: 12)
(view all)
104       VAREESGKPGAHVTV     PLMD
112       PGAHVTVKKLFVGGI     PLMD
113       GAHVTVKKLFVGGIK     PLMD
120       KLFVGGIKEDTEEHH     PLMD
137       DYFEEYGKIDTIEII     PLMD
168       DDHDPVDKIVLQKYH     PLMD
Sumoylation
(count: 9)
(view all)
104       VAREESGKPGAHVTV     PLMD
120       KLFVGGIKEDTEEHH     PLMD
13        ETVPLERKKREKEQF     PLMD
151       ITDRQSGKKRGFGFV     PLMD
152       TDRQSGKKRGFGFVT     PLMD
168       DDHDPVDKIVLQKYH     PLMD
Malonylation
(count: 2)
113       GAHVTVKKLFVGGIK     PLMD
120       KLFVGGIKEDTEEHH     PLMD
Methylation
(count: 1)
104       VAREESGKPGAHVTV     PLMD
Succinylation
(count: 1)
120       KLFVGGIKEDTEEHH     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource