P22091

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TAL1_MOUSE; P22091;
Entrez ID 21349
GenBank Protein ID NM_001287388.1; NM_011527.3; XM_006502910.3; XM_006502912.3; XM_006502913.3; XM_006502914.3; XM_006502915.3; XM_006502916.2;
GenBank Nucleotide ID NP_001274317.1; NP_035657.1; XP_006502973.1; XP_006502975.1; XP_006502976.1; XP_006502977.1; XP_006502978.1; XP_006502979.1;
Protein Name T-cell acute lymphocytic leukemia protein 1 homolog (TAL-1) (Stem cell protein)
Gene Name Tal1; Scl; Tal-1
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionImplicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Sequence
(Fasta)		MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP VIELGARSGA 60
GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA PAPAPASAPA ELPGDGRMVQ 120
LSPPALAAPA GPGRALLYSL SQPLASLGSG FFGEPDAFPM FTNNNRVKRR PSPYEMEISD 180
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA 240
KLLNDQEEEG TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD 300
SYTEEPTPKH TSRSLHPALL PAADGAGPR

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1AcetylationErythroleukemiaUK22111118214
[Reference]: Furthermore, P/CAF protein, TAL1-P/CAF interaction and TAL1 acetylation increased significantly in murine erythroleukemia cells induced to differentiate in culture, while enforced expression of an acetylation-defective P/CAF mutant inhibited endogenous TAL1 acetylation, TAL1 DNA-binding activity, TAL1-directed transcription and terminal differentiation of these cells.
2AcetylationErythroleukemiaUK22211118214
[Reference]: Furthermore, P/CAF protein, TAL1-P/CAF interaction and TAL1 acetylation increased significantly in murine erythroleukemia cells induced to differentiate in culture, while enforced expression of an acetylation-defective P/CAF mutant inhibited endogenous TAL1 acetylation, TAL1 DNA-binding activity, TAL1-directed transcription and terminal differentiation of these cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D054218 ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
MESH:D054198 ; Precursor Cell Lymphoblastic Leukemia-Lymphoma

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 122       DGRMVQLSPPALAAP     dbPAF
172       NRVKRRPSPYEMEIS     dbPAF
216       ELRKLIPTHPPDKKL     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource