| Tag | Content |
|---|---|
| UniProt Accession | ERBB3_HUMAN; P21860; |
| Entrez ID | 2065 |
| GenBank Protein ID | NM_001005915.1; NM_001982.3; |
| GenBank Nucleotide ID | NP_001005915.1; NP_001973.2; |
| Protein Name | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) |
| Gene Name | ERBB3; HER3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). |
| Sequence (Fasta) | MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM 60 GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120 LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 180 RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 240 TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300 CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 360 LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420 RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TKVLRGPTEE 480 RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 540 REFAHEAECF SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI 600 YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA GLVVIFMMLG 660 GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 720 GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG 780 SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 840 LLKSPSQVQV ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 900 VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 960 LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL EEVELEPELD LDLDLEAEED 1020 NLATTTLGSA LSLPVGTLNR PRGSQSLLSP SSGYMPMNQG NLGESCQESA VSGSSERCPR 1080 PVSLHPMPRG CLASESSEGH VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL 1140 TPVTPLSPPG LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM 1200 NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP TAGTTPDEDY 1260 EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH QAPHVHYARL KTLRSLEATD 1320 SAFDNPDYWH SRLFPKANAQ RT 1343 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | colon, gastric, head and neck, bladder, skin |
| CTD (Curated) (count: 8) (view all) | MESH:D001943
; Breast Neoplasms MESH:D018450 ; Disease Progression MESH:D005706 ; Gallbladder Neoplasms MESH:C564369 ; Lethal Congenital Contracture Syndrome 2 MESH:D008175 ; Lung Neoplasms MESH:C538339 ; Nasopharyngeal carcinoma |
| DisGeNet (Curated) (count: 28) (view all) | C0003886; Arthrogryposis
C0005586; Bipolar Disorder C0011570; Mental Depression C0013604; Edema C0016978; gallbladder neoplasm C0020224; Polyhydramnios |
| HGMD (count: 1) | CS073473; Contracture syndrome type 2; Splicing
|
| GWASdb (count: 9) (view all) | rs34379766; Obesity-related traits; obesity
rs7971751; Asthma; asthma rs877636; Polycystic ovary syndrome; polycystic ovary syndrome rs2292239; Type 1 diabetes; type 1 diabetes mellitus rs2292239; Multiple complex diseases; Null rs2292239; Type 1 diabetes autoantibodies; type 1 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 36) (view all) | 1054 LLSPSSGYMPMNQGN dbPAF
1094 MPRGCLASESSEGHV dbPAF 1096 RGCLASESSEGHVTG dbPAF 1097 GCLASESSEGHVTGS dbPAF 1104 SEGHVTGSEAELQEK dbPAF 1123 RSRSRSRSPRPRGDS dbPAF |
| Methylation (count: 1) | 736 IPEGESIKIPVCIKV PLMD |