| Tag | Content |
|---|---|
| UniProt Accession | EPHA1_HUMAN; P21709; |
| Entrez ID | 2041 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) |
| Gene Name | EPHA1; EPH; EPHT; EPHT1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
| Sequence (Fasta) | MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG 60 TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE 120 TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLV SGSVKLNVER CSLGRLTRRG 180 LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR 240 PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ 300 STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG 360 RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE 420 AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT 480 YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS 540 RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV 600 DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD 660 TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ 720 LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT 780 YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE 840 DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM 900 TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL 960 PGHQKRILCS IQGFKD 977 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D000544
; Alzheimer Disease MESH:D015179 ; Colorectal Neoplasms |
| DisGeNet (Curated) (count: 2) | C0002395; Alzheimer's Disease
C0009404; Colorectal Neoplasms |
| GWASdb (count: 2) | rs4726618; Alzheimer's disease (late onset); Alzheimer's disease
rs4421280; Insulin resistance; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 16) (view all) | 153 TTVAADQSFTIRDLV dbPAF
155 VAADQSFTIRDLVSG dbPAF 33 KEVTLMDTSKAQGEL dbPAF 34 EVTLMDTSKAQGELG dbPAF 599 DKLWLKPYVDLQAYE dbPAF 605 PYVDLQAYEDPAQGA dbPAF |
| Ubiquitination (count: 3) | 593 TDVDREDKLWLKPYV PLMD
597 REDKLWLKPYVDLQA PLMD 787 TYETQGGKIPIRWTA PLMD |