Tag | Content |
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UniProt Accession | SCF_HUMAN; P21583; |
Entrez ID | 4254 |
GenBank Protein ID | NM_000899.4; NM_003994.5; |
GenBank Nucleotide ID | NP_000890.1; NP_003985.2; |
Protein Name | Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] |
Gene Name | KITLG; MGF; SCF |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
Sequence (Fasta) | MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD YMITLKYVPG 60 MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI IDKLVNIVDD LVECVKENSS 120 KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA FKDFVVASET SDCVVSSTLS PEKDSRVSVT 180 KPFMLPPVAA SSLRNDSSSS NRKAKNPPGD SSLHWAAMAL PALFSLIIGF AFGALYWKKR 240 QPSLTRAVEN IQINEEDNEI SMLQEKEREF QEV 274 |
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Database | Annotation |
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CTD (Curated) (count: 10) (view all) | MESH:D002277
; Carcinoma OMIM:616697 ; DEAFNESS, AUTOSOMAL DOMINANT 69 MESH:D064420 ; Drug-Related Side Effects and Adverse Reactions OMIM:145250 ; HYPERPIGMENTATION WITH OR WITHOUT HYPOPIGMENTATION, FAMILIAL PROGRESSIVE MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental |
DisGeNet (Curated) (count: 23) (view all) | C0018784; Sensorineural Hearing Loss (disorder)
C0024667; Animal Mammary Neoplasms C0024668; Mammary Neoplasms, Experimental C0027430; Nasal Polyps C0027658; Neoplasms, Germ Cell and Embryonal C0039590; Testicular Neoplasms |
HGMD (count: 1) | CM092889; Progressive hyperpigmentation; Missense/nonsense
|
GWASdb (count: 31) (view all) | rs995030; Testicular germ cell tumor; testicular germ cell cancer
rs995030; Testicular cancer; testicular cancer rs995030; Nasopharyngeal carcinoma; nasopharynx carcinoma rs995030; Testicular germ cell cancer; testicular germ cell cancer rs11104911; Testicular germ cell cancer; testicular germ cell cancer rs11104913; Multiple complex diseases; Null |
PTM | Modification Sites |
---|---|
Ubiquitination (count: 5) | 116 DDLVECVKENSSKDL PLMD
128 KDLKKSFKSPEPRLF PLMD 152 NRSIDAFKDFVVASE PLMD 181 DSRVSVTKPFMLPPV PLMD 266 EISMLQEKEREFQEV PLMD |
Network | Interaction | ||
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A | B | Source | |