| Tag | Content |
|---|---|
| UniProt Accession | RASA1_HUMAN; P20936; |
| Entrez ID | 5921 |
| GenBank Protein ID | NM_002890.2; NM_022650.2; |
| GenBank Nucleotide ID | NP_002881.1; NP_072179.1; |
| Protein Name | Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) |
| Gene Name | RASA1; GAP; RASA |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. |
| Sequence (Fasta) | MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP GLVETGVAGT 60 LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAVAGP SGDMALTKLP 120 TSLLAETLGP GGGFPPLPPP PYLPPLGAGL GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ 180 WYHGKLDRTI AEERLRQAGK SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY 240 IGGRRFSSLS DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS 300 FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI WFHGKISKQE 360 AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK ICPTPNNQFM MGGRYYNSIG 420 DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY 480 LLKKGKGKRW KNLYFILEGS DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC 540 FQIVVQHFSE EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI 600 EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD INRFEITLSN 660 KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG IEPGSLRVRA RYSMEKIMPE 720 EEYSEFKELI LQKELHVVYA LSHVCGQDRT LLASILLRIF LHEKLESLLL CTLNDREISM 780 EDEATTLFRA TTLASTLMEQ YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED 840 VNTNLTHLLN ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV 900 FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE PYMEGVNPFI 960 KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE ICVAHSDELR TLSNERGAQQ 1020 HVLKKLLAIT ELLQQKQNQY TKTNDVR 1048 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 10) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D001165 ; Arteriovenous Malformations MESH:C564254 ; Capillary Malformation-Arteriovenous Malformation MESH:D002277 ; Carcinoma MESH:D002280 ; Carcinoma, Basal Cell MESH:D002294 ; Carcinoma, Squamous Cell |
| HGMD (count: 50) (view all) | CD033725; Capillary malformation-arteriovenous malformation; Small deletions
CD084196; Capillary malformation-arteriovenous malformation; Small deletions CD084197; Capillary malformation-arteriovenous malformation; Small deletions CD084198; Capillary malformation-arteriovenous malformation; Small deletions CD033722; Capillary malformation-arteriovenous malformation; Small deletions CD084199; Capillary malformation-arteriovenous malformation; Small deletions |
| GWASdb (count: 3) | rs16902608; LDL cholesterol; atherosclerosis|coronary artery disease
rs35148638; HIV-1 control; Human immunodeficiency virus infectious disease rs3752862; Alcohol dependence; alcohol dependence |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 14) (view all) | 164 DSLDGPEYEEEEVAI dbPAF
239 IIAMCGDYYIGGRRF dbPAF 240 IAMCGDYYIGGRRFS dbPAF 418 MGGRYYNSIGDIIDH dbPAF 453 QEQVLNDTVDGKEIY dbPAF 460 TVDGKEIYNTIRRKT dbPAF |
| Malonylation (count: 1) | 834 SCELSPSKLEKNEDV PLMD |