| Tag | Content |
|---|---|
| UniProt Accession | PSB1_HUMAN; P20618; |
| Entrez ID | 5689 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Proteasome subunit beta type-1 (EC 3.4.25.1) (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) |
| Gene Name | PSMB1; PSC5 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). |
| Sequence (Fasta) | MLSSTAMYSA PGRDLGMEPH RAAGPLQLRF SPYVFNGGTI LAIAGEDFAI VASDTRLSEG 60 FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL KMYKHSNNKA MTTGAIAAML 120 STILYSRRFF PYYVYNIIGG LDEEGKGAVY SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ 180 VGFKNMQNVE HVPLSLDRAM RLVKDVFISA AERDVYTGDA LRICIVTKEG IREETVSLRK 240 D 242 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D054058
; Acute Coronary Syndrome MESH:D010003 ; Osteoarthritis MESH:D010523 ; Peripheral Nervous System Diseases |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 17) (view all) | 125 AMLSTILYSRRFFPY dbPAF
132 YSRRFFPYYVYNIIG dbPAF 135 RFFPYYVYNIIGGLD dbPAF 150 EEGKGAVYSFDPVGS dbPAF 158 SFDPVGSYQRDSFKA dbPAF 162 VGSYQRDSFKAGGSA dbPAF |
| Acetylation (count: 5) | 184 LDNQVGFKNMQNVEH PLMD
204 DRAMRLVKDVFISAA PLMD 228 LRICIVTKEGIREET PLMD 73 RDSPKCYKLTDKTVI PLMD 77 KCYKLTDKTVIGCSG PLMD |
| Ubiquitination (count: 10) (view all) | 104 EARLKMYKHSNNKAM PLMD
109 MYKHSNNKAMTTGAI PLMD 164 SYQRDSFKAGGSASA PLMD 184 LDNQVGFKNMQNVEH PLMD 204 DRAMRLVKDVFISAA PLMD 228 LRICIVTKEGIREET PLMD |
| Glycation (count: 1) | 204 DRAMRLVKDVFISAA PLMD |
| Malonylation (count: 1) | 204 DRAMRLVKDVFISAA PLMD |
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