P20309

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession ACM3_HUMAN; P20309;
Entrez ID 1131
GenBank Protein ID NM_000740.3; NM_001347716.1; XM_005273032.3; XM_011544041.2; XM_011544043.2; XM_011544044.2; XM_011544046.2; XM_011544047.2; XM_017000152.1; XM_017000153.1; XM_017000154.1; XM_017000155.1; XM_017000156.1; XM_017000157.1; XM_017000158.1; XM_017000159.1; XM_017000160.1; XM_017000161.1; XM_017000162.1; XM_017000163.1;
GenBank Nucleotide ID NP_000731.1; NP_001334645.1; XP_005273089.1; XP_011542343.1; XP_011542345.1; XP_011542346.1; XP_011542348.1; XP_011542349.1; XP_016855641.1; XP_016855642.1; XP_016855643.1; XP_016855644.1; XP_016855645.1; XP_016855646.1; XP_016855647.1; XP_016855648.1; XP_016855649.1; XP_016855650.1; XP_016855651.1; XP_016855652.1;
Protein Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionThe muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Sequence
(Fasta)		MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS SPDGTTDDPL 60
GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK TVNNYFLLSL ACADLIIGVI 120
SMNLFTTYII MNRWALGNLA CDLWLAIDYV ASNASVMNLL VISFDRYFSI TRPLTYRAKR 180
TTKRAGVMIG LAWVISFVLW APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF 240
YMPVTIMTIL YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM 300
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA SSDEEDIGSE 360
TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD LERKADKLQA QKSVDDGGSF 420
PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS TATLPLSFKE ATLAKRFALK TRSQITKRKR 480
MSLVKEKKAA QTLSAILLAF IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN 540
PVCYALCNKT FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL 591

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationNeuroblastomaU11856737
[Reference]: We have previously shown that overexpression of G protein-coupled receptor kinase 6 (GRK6) enhanced the phosphorylation and desensitization of the endogenously expressed M(3) muscarinic acetylcholine (mACh) receptor in human SH-SY5Y neuroblastoma cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:D001201 ; Ascites
MESH:D056486 ; Chemical and Drug Induced Liver Injury
MESH:D003456 ; Cryptorchidism
MESH:D008103 ; Liver Cirrhosis
MESH:D011535 ; Prune Belly Syndrome
MESH:D001745 ; Urinary Bladder Diseases
DisGeNet (Curated)
(count: 43)
(view all)		C0003466; Anus, Imperforate
C0003962; Ascites
C0005586; Bipolar Disorder
C0005686; Urinary Bladder Diseases
C0009081; Congenital clubfoot
C0009806; Constipation
HGMD
(count: 1)		CR067509; Diabetes, type 2, increased risk, assoc. ?; Regulatory
GWASdb
(count: 14)
(view all)		rs10754677; Sudden cardiac arrest; coronary artery disease
rs1867266; Smoking initiation; nicotine dependence
rs7523711; Multiple complex diseases; Null
rs6694025; Multiple complex diseases; Null
rs7527723; Multiple complex diseases; Null
rs645248; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 291       TGSSRSCSSYELQQQ     dbPAF
365       GSETRAIYSIVLKLP     dbPAF
366       SETRAIYSIVLKLPG     dbPAF
Ubiquitination
(count: 4)		 412       ADKLQAQKSVDDGGS     PLMD
426       SFPKSFSKLPIQLES     PLMD
439       ESAVDTAKTSDVNSS     PLMD
449       DVNSSVGKSTATLPL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource