Tag | Content |
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UniProt Accession | NFKB1_HUMAN; P19838; |
Entrez ID | 4790 |
GenBank Protein ID | NM_001165412.1; NM_001319226.1; NM_003998.3; |
GenBank Nucleotide ID | NP_001158884.1; NP_001306155.1; NP_003989.2; |
Protein Name | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] |
Gene Name | NFKB1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dim(view all) |
Sequence (Fasta) | MAEDDPYLGR PEQMFHLDPS LTHTIFNPEV FQPQMALPTD GPYLQILEQP KQRGFRFRYV 60 CEGPSHGGLP GASSEKNKKS YPQVKICNYV GPAKVIVQLV TNGKNIHLHA HSLVGKHCED 120 GICTVTAGPK DMVVGFANLG ILHVTKKKVF ETLEARMTEA CIRGYNPGLL VHPDLAYLQA 180 EGGGDRQLGD REKELIRQAA LQQTKEMDLS VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY 240 DSKAPNASNL KIVRMDRTAG CVTGGEEIYL LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF 300 SPTDVHRQFA IVFKTPKYKD INITKPASVF VQLRRKSDLE TSEPKPFLYY PEIKDKEEVQ 360 RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS GGGGGGTGST GPGYSFPHYG FPTYGGITFH 420 PGTTKSNAGM KHGTMDTESK KDPEGCDKSD DKNTVNLFGK VIETTEQDQE PSEATVGNGE 480 VTLTYATGTK EESAGVQDNL FLEKAMQLAK RHANALFDYA VTGDVKMLLA VQRHLTAVQD 540 ENGDSVLHLA IIHLHSQLVR DLLEVTSGLI SDDIINMRND LYQTPLHLAV ITKQEDVVED 600 LLRAGADLSL LDRLGNSVLH LAAKEGHDKV LSILLKHKKA ALLLDHPNGD GLNAIHLAMM 660 SNSLPCLLLL VAAGADVNAQ EQKSGRTALH LAVEHDNISL AGCLLLEGDA HVDSTTYDGT 720 TPLHIAAGRG STRLAALLKA AGADPLVENF EPLYDLDDSW ENAGEDEGVV PGTTPLDMAT 780 SWQVFDILNG KPYEPEFTSD DLLAQGDMKQ LAEDVKLQLY KLLEIPDPDK NWATLAQKLG 840 LGILNNAFRL SPAPSKTLMD NYEVSGGTVR ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ 900 AHSLPLSPAS TRQQIDELRD SDSVCDSGVE TSFRKLSFTE SLTSGASLLT LNKMPHDYGQ 960 EGPLEGKI 969 |
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Database | Annotation |
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CTD (Curated) (count: 12) (view all) | MESH:D000230
; Adenocarcinoma MESH:D002545 ; Brain Ischemia MESH:D002471 ; Cell Transformation, Neoplastic MESH:D003110 ; Colonic Neoplasms MESH:D017074 ; Common Variable Immunodeficiency MESH:D003924 ; Diabetes Mellitus, Type 2 |
HGMD (count: 1) | CD040190; Ulcerative colitis, increased risk, association; Small deletions
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GWASdb (count: 15) (view all) | rs4647972; Coronary heart disease; coronary artery disease
rs3774937; Weight; obesity rs230530; Primary biliary cirrhosis; primary biliary cirrhosis rs4647992; Longevity; Null rs230529; Schizophrenia (treatment refractory); schizophrenia rs230528; Height; Null |
PTM | Modification Sites |
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Phosphorylation (count: 34) (view all) | 165 TEACIRGYNPGLLVH dbPAF
20 QMFHLDPSLTHTIFN dbPAF 223 FTAFLPDSTGSFTRR dbPAF 228 PDSTGSFTRRLEPVV dbPAF 240 PVVSDAIYDSKAPNA dbPAF 242 VSDAIYDSKAPNASN dbPAF |
Acetylation (count: 5) | 116 HAHSLVGKHCEDGIC PLMD
251 APNASNLKIVRMDRT PLMD 431 TKSNAGMKHGTMDTE PLMD 440 GTMDTESKKDPEGCD PLMD 441 TMDTESKKDPEGCDK PLMD |
Ubiquitination (count: 12) (view all) | 130 CTVTAGPKDMVVGFA PLMD
148 ILHVTKKKVFETLEA PLMD 205 QAALQQTKEMDLSVV PLMD 251 APNASNLKIVRMDRT PLMD 356 YYPEIKDKEEVQRKR PLMD 504 QDNLFLEKAMQLAKR PLMD |
Sumoylation (count: 1) | 325 YKDINITKPASVFVQ PLMD |
Malonylation (count: 2) | 251 APNASNLKIVRMDRT PLMD
277 LLCDKVQKDDIQIRF PLMD |