P19429

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TNNI3_HUMAN; P19429;
Entrez ID 7137
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Troponin I, cardiac muscle (Cardiac troponin I)
Gene Name TNNI3; TNNC1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTroponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence
(Fasta)		MADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK TLLLQIAKQE 60
LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL HARVDKVDEE RYDIEAKVTK 120
NITEIADLTQ KIFDLRGKFK RPTLRRVRIS ADAMMQALLG ARAKESLDLR AHLKQVKKED 180
TEKENREVGD WRKNIDALSG MEGRKKKFES 211

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationDilated cardiomyopathyDS522972900
[Reference]: The results show that in heart failure there is a decrease in the extent of phosphorylation of the known protein kinase A sites (S22, S23) and other The results show that in heart failure there is a decrease in the extent of phosphorylation of the known protein kinase A sites (S22, S23) and other newly discovered phosphorylation sites located in the N-terminal extension of cardiac troponin I (S4, S5, Y25)newly discovered phosphorylation sites located in the N-terminal extension of cardiac troponin I (S4, S5, Y25)
2Serine PhosphorylationDilated cardiomyopathyDS2322972900
[Reference]: The results show that in heart failure there is a decrease in the extent of phosphorylation of the known protein kinase A sites (S22, S23)
3Serine PhosphorylationCardiovascular/heart diseasetumor tissueUS23/2423564307
[Reference]: Site-specific analysis of TnI phosphorylation revealed phenotype-specific differences such that Hyp samples demonstrated significant increases in phosphorylation at serine 22/23 and Dil samples had significant decreases at serine 43.
4Tyrosine PhosphorylationDilated cardiomyopathyDY2622972900
[Reference]: Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.
5Serine PhosphorylationCardiovascular/heart diseasetumor tissueDS4223564307
[Reference]: Site-specific analysis of TnI phosphorylation revealed phenotype-specific differences such that Hyp samples demonstrated significant increases in phosphorylation at serine 22/23 and Dil samples had significant decreases at serine 43.
6Serine PhosphorylationHeart failureUS4222972900
[Reference]: The results show that in heart failure there is a decrease in the extent of phosphorylation of the known protein kinase A sites (S22, S23) and other newly discovered phosphorylation sites located in the N-terminal extension of cardiac troponin I (S4, S5, Y25), an increase in phosphorylation of the protein kinase C sites (S41, S43, T142),
7Serine PhosphorylationDilated cardiomyopathyUS4422972900
[Reference]: Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.
8Serine PhosphorylationDilated cardiomyopathyUS7722972900
[Reference]: An increase in phosphorylation of the IT-arm domain residues (S76, T77) and C-terminal domain novel phosphorylation sites of cardiac troponin I?
9Threonine PhosphorylationDilated cardiomyopathyUT7822972900
[Reference]: Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.
10Serine PhosphorylationHeart failureUS16622972900
[Reference]: Functionally significant phosphorylation alterations occurred on individual residues of cardiac troponin I in heart failure, likely reflecting an imbalance in kinase/phosphatase activity.
11Threonine PhosphorylationDilated cardiomyopathyUT18122972900
[Reference]: Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.
12Serine PhosphorylationDilated cardiomyopathyUS19922972900
[Reference]: Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)		MESH:D054058 ; Acute Coronary Syndrome
MESH:D009202 ; Cardiomyopathies
MESH:D002311 ; Cardiomyopathy, Dilated
MESH:C567654 ; Cardiomyopathy, Dilated, 1FF
MESH:C567505 ; Cardiomyopathy, Dilated, 2a
OMIM:613690 ; CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7
HGMD
(count: 37)
(view all)		CD086250; Cardiomyopathy, restrictive; Small deletions
CD031544; Cardiomyopathy, hypertrophic; Small deletions
CD972477; Cardiomyopathy, hypertrophic; Small deletions
CD086097; Increased left ventricular wall thickness; Small deletions
CG005190; Cardiomyopathy, hypertrophic; Gross deletions
CM040497; Cardiomyopathy, hypertrophic; Missense/nonsense
GWASdb
(count: 2)		rs2288529; Multiple complex diseases; Null
rs3729709; Fasting plasma glucose; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 20)
(view all)		 112       DKVDEERYDIEAKVT     dbPAF
129       ITEIADLTQKIFDLR     dbPAF
143       RGKFKRPTLRRVRIS     dbPAF
150       TLRRVRISADAMMQA     dbPAF
166       LGARAKESLDLRAHL     dbPAF
181       KQVKKEDTEKENREV     dbPAF
Methylation
(count: 1)		 40        PHAKKKSKISASRKL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource