| Tag | Content |
|---|---|
| UniProt Accession | ELK1_HUMAN; P19419; |
| Entrez ID | 2002 |
| GenBank Protein ID | NM_001114123.2; NM_001257168.1; NM_005229.4; XM_017029339.1; |
| GenBank Nucleotide ID | NP_001107595.1; NP_001244097.1; NP_005220.2; XP_016884828.1; |
| Protein Name | ETS domain-containing protein Elk-1 |
| Gene Name | ELK1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). |
| Sequence (Fasta) | MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK NKTNMNYDKL 60 SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP PQPEVSVTST MPNVAPAAIH 120 AAPGDTVSGK PGTPKGAGMA GPGGLARSSR NEYMRSGLYS TFTIQSLQPQ PPPHPRPAVV 180 LPSAAPAGAA APPSGSRSTS PSPLEACLEA EEAGLPLQVI LTPPEAPNLK SEELNVEPGL 240 GRALPPEVKV EGPKEELEVA GERGFVPETT KAEPEVPPQE GVPARLPAVV MDTAGQAGGH 300 AASSPEISQP QKGRKPRDLE LPLSPSLLGG PGPERTPGSG SGSGLQAPGP ALTPSLLPTH 360 TLTPVLLTPS SLPPSIHFWS TLSPIAPRSP AKLSFQFPSS GSAQVHIPSI SVDGLSTPVV 420 LSPGPQKP 429 |
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| Database | Annotation |
|---|---|
| HGMD (count: 1) | CM002951; Mental retardation, X-linked; Missense/nonsense
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 20) (view all) | 160 YMRSGLYSTFTIQSL dbPAF
166 YSTFTIQSLQPQPPP dbPAF 194 AGAAAPPSGSRSTSP dbPAF 196 AAAPPSGSRSTSPSP dbPAF 198 APPSGSRSTSPSPLE dbPAF 222 LPLQVILTPPEAPNL dbPAF |
| Acetylation (count: 1) | 312 PEISQPQKGRKPRDL PLMD |
| Sumoylation (count: 3) | 230 PPEAPNLKSEELNVE PLMD
249 RALPPEVKVEGPKEE PLMD 254 EVKVEGPKEELEVAG PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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