| Tag | Content |
|---|---|
| UniProt Accession | TAU_RAT; P19332; |
| Entrez ID | 29477 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) |
| Gene Name | Mapt; Mtapt; Tau |
| Organism | Rattus norvegicus |
| NCBI Taxa ID | 10116 |
| Functional Description | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Sequence (Fasta) | MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 60 AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQEPQKVEI 120 FSQSLLVEPG RREGQAPDSG ISDWTHQQVP SMSGAPLPPQ GLREATHQPL GTRPEDVERS 180 HPASELLWQE SPQKEAWGKD RLGSEEEVDE DITMDESSQE SPPSQASLAP GTATPQARSV 240 SASGVSGETT SIPGFPAEGS IPLPADFFSK VSAETQASPP EGPGTGPSEE GHEAAPEFTF 300 HVEIKASAPK EQDLEGATVV GAPAEEQKAR GPSVGKGTKE ASLLEPTDKQ PAAGLPGRPV 360 SRVPQLKARV AGVSKDRTGN DEKKAKTSTP SCAKTPSNRP CLSPTRPTPG SSDPLIKPSS 420 PAVCPEPATS PKYVSSVTPR NGSPGTKQMK LKGADGKTGA KIATPRGAAT PGQKGTSNAT 480 RIPAKTTPSP KTPPGSGEPP KSGERSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV 540 RTPPKSPSAS KSRLQTAPVP MPDLKNVRSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS 600 KCGSKDNIKH VPGGGSVHIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR 660 VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS 720 NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GL 753 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 19) (view all) | MESH:D000544
; Alzheimer Disease MESH:D003072 ; Cognition Disorders MESH:D003704 ; Dementia MESH:D004195 ; Disease Models, Animal MESH:D057180 ; Frontotemporal Dementia MESH:D007859 ; Learning Disorders |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 41) (view all) | 172 ATHQPLGTRPEDVER dbPAF
191 SELLWQESPQKEAWG dbPAF 204 WGKDRLGSEEEVDED dbPAF 224 SSQESPPSQASLAPG dbPAF 227 ESPPSQASLAPGTAT dbPAF 342 GKGTKEASLLEPTDK dbPAF |
| Acetylation (count: 6) | 565 PVPMPDLKNVRSKIG PLMD
591 GKVQIINKKLDLSNV PLMD 609 CGSKDNIKHVPGGGS PLMD 628 YKPVDLSKVTSKCGS PLMD 654 QVEVKSEKLDFKDRV PLMD 658 KSEKLDFKDRVQSKI PLMD |
| Ubiquitination (count: 1) | 565 PVPMPDLKNVRSKIG PLMD |