Tag | Content |
---|---|
UniProt Accession | PLCG1_HUMAN; P19174; |
Entrez ID | 5335 |
GenBank Protein ID | NM_002660.2; NM_182811.1; |
GenBank Nucleotide ID | NP_002651.2; NP_877963.1; |
Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) |
Gene Name | PLCG1; PLC1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. |
Sequence (Fasta) | MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 60 TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 120 SLQATSEDEV NMWIKGLTWL MEDTLQAPTP LQIERWLRKQ FYSVDRNRED RISAKDLKNM 180 LSQVNYRVPN MRFLRERLTD LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA 240 GERPELCRVS LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 300 FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL EAYARCLRMG 360 CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH AFVASEYPVI LSIEDHCSIA 420 QQRNMAQYFK KVLGDTLLTK PVEISADGLP SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM 480 YSENDISNSI KNGILYLEDP VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS 540 STELHSNEKW FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 600 RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE MRLSEPVPQT 660 NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN SYAISFRAEG KIKHCRVQQE 720 GQTVMLGNSE FDSLVDLISY YEKHPLYRKM KLRYPINEEA LEKIGTAEPD YGALYEGRNP 780 GFYVEANPMP TFKCAVKALF DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW 840 FPSNYVEEMV NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 900 MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA LELSELVVYC 960 RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF LQYNRLQLSR IYPKGQRLDS 1020 SNYDPLPMWI CGSQLVALNF QTPDKPMQMN QALFMTGRHC GYVLQPSTMR DEAFDPFDKS 1080 SLRGLEPCAI SIEVLGARHL PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW 1140 PAKPFHFQIS NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 1200 ELASLLIKID IFPAKENGDL SPFSGTSLRE RGSDASGQLF HGRAREGSFE SRYQQPFEDF 1260 RISQEHLADH FDSRERRAPR RTRVNGDNRL 1291 |
|
Database | Annotation |
---|---|
Cancer Gene Census | angiosarcoma |
CTD (Curated) (count: 4) | MESH:D006394
; Hemangiosarcoma MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell MESH:D016410 ; Lymphoma, T-Cell, Cutaneous MESH:D012751 ; Sezary Syndrome |
GWASdb (count: 4) | rs12624863; Taste perception; sensory system disease
rs2228246; Suicidal ideation; major depressive disorder rs753381; Metabolic syndrome phenotype; Null rs753381; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis |
PTM | Modification Sites |
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Phosphorylation (count: 52) (view all) | 1003 KGKKFLQYNRLQLSR dbPAF
1221 AKENGDLSPFSGTSL dbPAF 1224 NGDLSPFSGTSLRER dbPAF 1226 DLSPFSGTSLRERGS dbPAF 1227 LSPFSGTSLRERGSD dbPAF 1233 TSLRERGSDASGQLF dbPAF |
Acetylation (count: 4) | 941 DARLTEGKIMERRKK PLMD
987 MSSFPETKAEKYVNK PLMD 990 FPETKAEKYVNKAKG PLMD 999 VNKAKGKKFLQYNRL PLMD |
Ubiquitination (count: 25) (view all) | 1079 EAFDPFDKSSLRGLE PLMD
1143 LNPVWPAKPFHFQIS PLMD 1193 GYRAVPLKNNYSEDL PLMD 159 QIERWLRKQFYSVDR PLMD 175 REDRISAKDLKNMLS PLMD 178 RISAKDLKNMLSQVN PLMD |
Glycation (count: 1) | 925 ELQDWVKKIREVAQT PLMD |