P19174

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PLCG1_HUMAN; P19174;
Entrez ID 5335
GenBank Protein ID NM_002660.2; NM_182811.1;
GenBank Nucleotide ID NP_002651.2; NP_877963.1;
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene Name PLCG1; PLC1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Sequence
(Fasta)
MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 60
TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 120
SLQATSEDEV NMWIKGLTWL MEDTLQAPTP LQIERWLRKQ FYSVDRNRED RISAKDLKNM 180
LSQVNYRVPN MRFLRERLTD LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA 240
GERPELCRVS LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 300
FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL EAYARCLRMG 360
CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH AFVASEYPVI LSIEDHCSIA 420
QQRNMAQYFK KVLGDTLLTK PVEISADGLP SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM 480
YSENDISNSI KNGILYLEDP VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS 540
STELHSNEKW FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 600
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE MRLSEPVPQT 660
NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN SYAISFRAEG KIKHCRVQQE 720
GQTVMLGNSE FDSLVDLISY YEKHPLYRKM KLRYPINEEA LEKIGTAEPD YGALYEGRNP 780
GFYVEANPMP TFKCAVKALF DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW 840
FPSNYVEEMV NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 900
MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA LELSELVVYC 960
RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF LQYNRLQLSR IYPKGQRLDS 1020
SNYDPLPMWI CGSQLVALNF QTPDKPMQMN QALFMTGRHC GYVLQPSTMR DEAFDPFDKS 1080
SLRGLEPCAI SIEVLGARHL PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW 1140
PAKPFHFQIS NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 1200
ELASLLIKID IFPAKENGDL SPFSGTSLRE RGSDASGQLF HGRAREGSFE SRYQQPFEDF 1260
RISQEHLADH FDSRERRAPR RTRVNGDNRL 1291

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationEpidermoid carcinomaP10952974
[Reference]: In a human epidermoid carcinoma cell line (i.e. A431), 12(S)-HETE activates extracellular signal-regulated kinases 1/2 (ERK1/2), which is mediated by upstream kinases MEK and Raf. 12(S)-HETE stimulates phosphorylation of phospholipase Cgamma1 and activity of protein kinase Calpha (PKCalpha).
2Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY78322847294
[Reference]: Tumor cells while expressing variable proportions of cytoplasmic PLC?1, express PLC?1-pY1253 and PLC?1-pY783 predominantly in the nucleus. High expression of PLC?1, and of its activated forms, is associated with a worse clinical outcome in terms of incidence of distant metastases, and not of local relapse in T1-T2, N0 breast cancer patients undergone adjuvant chemotherapy.
3Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY125322847294
[Reference]: Tumor cells while expressing variable proportions of cytoplasmic PLC?1, express PLC?1-pY1253 and PLC?1-pY783 predominantly in the nucleus. High expression of PLC?1, and of its activated forms, is associated with a worse clinical outcome in terms of incidence of distant metastases

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
angiosarcoma
CTD (Curated)
(count: 4)
MESH:D006394 ; Hemangiosarcoma
MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell
MESH:D016410 ; Lymphoma, T-Cell, Cutaneous
MESH:D012751 ; Sezary Syndrome
GWASdb
(count: 4)
rs12624863; Taste perception; sensory system disease
rs2228246; Suicidal ideation; major depressive disorder
rs753381; Metabolic syndrome phenotype; Null
rs753381; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 52)
(view all)
1003      KGKKFLQYNRLQLSR     dbPAF
1221      AKENGDLSPFSGTSL     dbPAF
1224      NGDLSPFSGTSLRER     dbPAF
1226      DLSPFSGTSLRERGS     dbPAF
1227      LSPFSGTSLRERGSD     dbPAF
1233      TSLRERGSDASGQLF     dbPAF
Acetylation
(count: 4)
941       DARLTEGKIMERRKK     PLMD
987       MSSFPETKAEKYVNK     PLMD
990       FPETKAEKYVNKAKG     PLMD
999       VNKAKGKKFLQYNRL     PLMD
Ubiquitination
(count: 25)
(view all)
1079      EAFDPFDKSSLRGLE     PLMD
1143      LNPVWPAKPFHFQIS     PLMD
1193      GYRAVPLKNNYSEDL     PLMD
159       QIERWLRKQFYSVDR     PLMD
175       REDRISAKDLKNMLS     PLMD
178       RISAKDLKNMLSQVN     PLMD
Glycation
(count: 1)
925       ELQDWVKKIREVAQT     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
O00254P19174IntAct; MINT
O14490P19174IntAct
O15085P19174IntAct; MINT
O15360P19174IntAct
O43150P19174IntAct; MINT
O43281P19174IntAct; MINT
O43493P19174IntAct
O43561P19174IntAct
O43909P19174IntAct
O43918P19174IntAct
O60674P19174IntAct; MINT
O75167P19174IntAct
O75335P19174IntAct; MINT
O75369P19174IntAct; MINT
O94916P19174DIP
O95487P19174IntAct
O95817P19174HPRD
O95886P19174IntAct
P00519P19174IntAct; MINT
P00533P19174MINT;HPRD
P01008P19174IntAct
P04626P19174MINT;HPRD
P06213P19174MINT
P09327P19174IntAct
P09619P19174DIP
P10301P19174IntAct; MINT
P10721P19174HPRD
P10912P19174IntAct; MINT
P11678P19174IntAct
P12236P19174MINT
P12931P19174HPRD
P15498P19174HPRD; MINT
P15918P19174IntAct; MINT
P18031P19174MINT
P19174P20273IntAct
P19174P20810IntAct
P19174P20936MINT
P19174P21333IntAct; MINT
P19174P21817IntAct; MINT
P19174P21860MINT
P19174P22681HPRD; MINT
P19174P25445DIP
P19174P26373IntAct; MINT
P19174P26951IntAct; MINT
P19174P27816IntAct; MINT
P19174P27986MINT
P19174P31749MINT
P19174P31994IntAct; MINT
P19174P31995IntAct; MINT
P19174P35968HPRD
P19174P42684IntAct; MINT
P19174P42702HPRD
P19174P43403HPRD
P19174P43405DIP;HPRD
P19174P47928IntAct; MINT
P19174P49792MINT
P19174P49802IntAct; MINT
P19174P49916IntAct
P19174P51816IntAct
P19174P61586HPRD
P19174P62993MINT
P19174P63000MINT
P19174P68104MINT
P19174Q00839DIP
P19174Q04912HPRD
P19174Q05639MINT
P19174Q05996IntAct; MINT
P19174Q06124MINT
P19174Q06187HPRD
P19174Q07666IntAct;HPRD
P19174Q07889IntAct; MINT
P19174Q07890IntAct; MINT
P19174Q13087IntAct
P19174Q13094MINT
P19174Q13111IntAct; MINT
P19174Q14008IntAct
P19174Q14108MINT
P19174Q14315IntAct; MINT
P19174Q15036IntAct; MINT
P19174Q7Z408IntAct; MINT
P19174Q86YH6MINT
P19174Q8IZP0MINT
P19174Q8TB24IntAct; MINT
P19174Q8WX92IntAct
P19174Q92832MINT
P19174Q92918IntAct; MINT
P19174Q92988IntAct
P19174Q96EV8IntAct; MINT
P19174Q96T58IntAct; MINT
P19174Q9BWF2IntAct; MINT
P19174Q9BXT4IntAct; MINT
P19174Q9BYB0IntAct; MINT
P19174Q9H1R2IntAct; MINT
P19174Q9H2P0IntAct
P19174Q9H5I1IntAct; MINT
P19174Q9H9L3IntAct
P19174Q9NPY5MINT
P19174Q9NQ76IntAct
P19174Q9NX09MINT
P19174Q9NZM4IntAct
P19174Q9UHI7IntAct
P19174Q9ULH1IntAct; MINT
P19174Q9UM73HPRD
P19174Q9UNH6IntAct
P19174Q9UPX8IntAct; MINT
P19174Q9Y2D5IntAct;MINT
P19174Q9Y4H2HPRD