| Tag | Content |
|---|---|
| UniProt Accession | ATF6A_HUMAN; P18850; |
| Entrez ID | 22926 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] |
| Gene Name | ATF6 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. |
| Sequence (Fasta) | MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL 60 DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE 120 LDLSSSSQMS PLSLYGENSN SLSSAEPLKE DKPVTGPRNK TENGLTPKKK IQVNSKPSIQ 180 PKPLLLPAAP KTQTNSSVPA KTIIIQTVPT LMPLAKQQPI ISLQPAPTKG QTVLLSQPTV 240 VQLQAPGVLP SAQPVLAVAG GVTQLPNHVV NVVPAPSANS PVNGKLSVTK PVLQSTMRNV 300 GSDIAVLRRQ QRMIKNRESA CQSRKKKKEY MLGLEARLKA ALSENEQLKK ENGTLKRQLD 360 EVVSENQRLK VPSPKRRVVC VMIVLAFIIL NYGPMSMLEQ DSRRMNPSVS PANQRRHLLG 420 FSAKEAQDTS DGIIQKNSYR YDHSVSNDKA LMVLTEEPLL YIPPPPCQPL INTTESLRLN 480 HELRGWVHRH EVERTKSRRM TNNQQKTRIL QGALEQGSNS QLMAVQYTET TSSISRNSGS 540 ELQVYYASPR SYQDFFEAIR RRGDTFYVVS FRRDHLLLPA TTHNKTTRPK MSIVLPAINI 600 NENVINGQDY EVMMQIDCQV MDTRILHIKS SSVPPYLRDQ QRNQTNTFFG SPPAATEATH 660 VVSTIPESLQ 671 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | OMIM:616517
; ACHROMATOPSIA 7 MESH:D001195 ; Asbestosis MESH:D003117 ; Color Vision Defects MESH:D007562 ; Creutzfeldt-Jakob Syndrome MESH:D020417 ; Nystagmus, Congenital MESH:D020795 ; Photophobia |
| DisGeNet (Curated) (count: 19) (view all) | C0003949; Asbestosis
C0009398; Color vision defect C0015310; Exotropia C0020490; Hyperopia C0022336; Creutzfeldt-Jakob disease C0035334; Retinitis Pigmentosa |
| HGMD (count: 3) | CM077506; Fasting plasma glucose level, association with ?; Missense/nonsense
CM068176; Diabetes, type 2, association with ?; Missense/nonsense CM068177; Diabetes, type 2, association with ?; Missense/nonsense |
| GWASdb (count: 34) (view all) | rs7519514; White blood cell count; hematopoietic system disease|myocardial infarction
rs7519514; Type 2 diabetes; type 2 diabetes mellitus rs905594; White blood cell count; hematopoietic system disease|myocardial infarction rs905594; Type 2 diabetes; type 2 diabetes mellitus rs905594; Diabetes Mellitus; diabetes mellitus rs1027700; Type 2 diabetes; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 100 LSPASSSYSVSSPRS dbPAF
103 ASSSYSVSSPRSVDS dbPAF 104 SSSYSVSSPRSVDSY dbPAF 16 GTMESPFSPGLFHRL dbPAF 166 NKTENGLTPKKKIQV dbPAF 296 TKPVLQSTMRNVGSD dbPAF |
| Acetylation (count: 4) | 176 KKIQVNSKPSIQPKP PLMD
182 SKPSIQPKPLLLPAA PLMD 201 TNSSVPAKTIIIQTV PLMD 87 ICTVKDIKAEPQPLS PLMD |
| Ubiquitination (count: 13) (view all) | 176 KKIQVNSKPSIQPKP PLMD
201 TNSSVPAKTIIIQTV PLMD 216 PTLMPLAKQQPIISL PLMD 290 NGKLSVTKPVLQSTM PLMD 339 LGLEARLKAALSENE PLMD 349 LSENEQLKKENGTLK PLMD |
| Sumoylation (count: 6) | 152 AEPLKEDKPVTGPRN PLMD
176 KKIQVNSKPSIQPKP PLMD 182 SKPSIQPKPLLLPAA PLMD 191 LLLPAAPKTQTNSSV PLMD 290 NGKLSVTKPVLQSTM PLMD 87 ICTVKDIKAEPQPLS PLMD |
| Glycation (count: 1) | 629 DTRILHIKSSSVPPY PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |