Tag | Content |
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UniProt Accession | ATF4_HUMAN; P18848; |
Entrez ID | 468 |
GenBank Protein ID | NM_001675.4; NM_182810.2; XM_017028807.1; |
GenBank Nucleotide ID | NP_001666.2; NP_877962.1; XP_016884296.1; |
Protein Name | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAX |
Gene Name | ATF4; CREB2; TXREB |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3(view all) |
Sequence (Fasta) | MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE 60 WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC 120 DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL 180 ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG 240 SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR 300 AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P 352 |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D018270
; Carcinoma, Ductal, Breast MESH:D000860 ; Hypoxia MESH:D009336 ; Necrosis |
PTM | Modification Sites |
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Phosphorylation (count: 12) (view all) | 107 LGIDDLETMPDDLLT dbPAF
114 TMPDDLLTTLDDTCD dbPAF 115 MPDDLLTTLDDTCDL dbPAF 119 LLTTLDDTCDLFAPL dbPAF 166 FLQPLPLSPGVLSST dbPAF 215 IKEEDTPSDNDSGIC dbPAF |
Acetylation (count: 5) | 267 PYDPPGEKMVAAKVK PLMD
272 GEKMVAAKVKGEKLD PLMD 274 KMVAAKVKGEKLDKK PLMD 277 AAKVKGEKLDKKLKK PLMD 311 EALTGECKELEKKNE PLMD |
Ubiquitination (count: 11) (view all) | 259 LCGSARPKPYDPPGE PLMD
267 PYDPPGEKMVAAKVK PLMD 299 ATRYRQKKRAEQEAL PLMD 311 EALTGECKELEKKNE PLMD 329 ERADSLAKEIQYLKD PLMD 335 AKEIQYLKDLIEEVR PLMD |
Sumoylation (count: 4) | 267 PYDPPGEKMVAAKVK PLMD
274 KMVAAKVKGEKLDKK PLMD 45 LEVAKHFKPHGFSSD PLMD 53 PHGFSSDKAKAGSSE PLMD |
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