P18848

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ATF4_HUMAN; P18848;
Entrez ID 468
GenBank Protein ID NM_001675.4; NM_182810.2; XM_017028807.1;
GenBank Nucleotide ID NP_001666.2; NP_877962.1; XP_016884296.1;
Protein Name Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAX
Gene Name ATF4; CREB2; TXREB
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3(view all)
Sequence
(Fasta)
MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE 60
WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC 120
DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL 180
ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG 240
SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR 300
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P 352

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationCoffin-Lowry SyndromePS24515109498
[Reference]: These findings identify ATF4 as a critical regulator of osteoblast differentiation and function, and indicate that lack of ATF4 phosphorylation by RSK2 may contribute to the skeletal phenotype of CLS
2Serine PhosphorylationNon-small cell lung cancer/carcinomaUS24523975372
[Reference]: Compared to bronchial epithelium and submucosal glands (total positive rate, 14.6% (12/82)), there was increased expression of p-ATF4 (ser 245) in non-small cell lung cancer cells (total positive rate, 42.7% (35/82)) (p?
3Serine PhosphorylationBreast cancer/tumor/carcinomaUS24522052162
[Reference]: Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
MESH:D018270 ; Carcinoma, Ductal, Breast
MESH:D000860 ; Hypoxia
MESH:D009336 ; Necrosis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 12)
(view all)
107       LGIDDLETMPDDLLT     dbPAF
114       TMPDDLLTTLDDTCD     dbPAF
115       MPDDLLTTLDDTCDL     dbPAF
119       LLTTLDDTCDLFAPL     dbPAF
166       FLQPLPLSPGVLSST     dbPAF
215       IKEEDTPSDNDSGIC     dbPAF
Acetylation
(count: 5)
267       PYDPPGEKMVAAKVK     PLMD
272       GEKMVAAKVKGEKLD     PLMD
274       KMVAAKVKGEKLDKK     PLMD
277       AAKVKGEKLDKKLKK     PLMD
311       EALTGECKELEKKNE     PLMD
Ubiquitination
(count: 11)
(view all)
259       LCGSARPKPYDPPGE     PLMD
267       PYDPPGEKMVAAKVK     PLMD
299       ATRYRQKKRAEQEAL     PLMD
311       EALTGECKELEKKNE     PLMD
329       ERADSLAKEIQYLKD     PLMD
335       AKEIQYLKDLIEEVR     PLMD
Sumoylation
(count: 4)
267       PYDPPGEKMVAAKVK     PLMD
274       KMVAAKVKGEKLDKK     PLMD
45        LEVAKHFKPHGFSSD     PLMD
53        PHGFSSDKAKAGSSE     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource