P18669

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PGAM1_HUMAN; P18669;
Entrez ID 5223
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B)
Gene Name PGAM1; PGAMA; CDABP0006
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInterconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Sequence
(Fasta)
MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ 60
KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD 120
VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR 180
VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR 240
KAMEAVAAQG KAKK 255

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationCancerstumor tissuePY2623653202
[Reference]: Moreover, Y26 phosphorylation of PGAM1 is common in human cancer cells and contributes to regulation of 3-phosphoglycerate and 2-phosphoglycerate levels, promoting cancer cell proliferation and tumour growth

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:D002277 ; Carcinoma
MESH:D002294 ; Carcinoma, Squamous Cell
MESH:D015674 ; Mammary Neoplasms, Animal
MESH:D008325 ; Mammary Neoplasms, Experimental
MESH:D009062 ; Mouth Neoplasms
HGMD
(count: 2)
CM083547; Phosphoglycerate mutase deficiency; Missense/nonsense
CM032985; Phosphoglycerate mutase deficiency; Missense/nonsense

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 14)
(view all)
118       QVKIWRRSYDVPPPP     dbPAF
119       VKIWRRSYDVPPPPM     dbPAF
133       MEPDHPFYSNISKDR     dbPAF
134       EPDHPFYSNISKDRR     dbPAF
14        VLIRHGESAWNLENR     dbPAF
146       DRRYADLTEDQLPSC     dbPAF
Acetylation
(count: 9)
(view all)
106       NKAETAAKHGEAQVK     PLMD
113       KHGEAQVKIWRRSYD     PLMD
138       PFYSNISKDRRYADL     PLMD
157       LPSCESLKDTIARAL     PLMD
176       EEIVPQIKEGKRVLI     PLMD
225       YELDKNLKPIKPMQF     PLMD
Ubiquitination
(count: 13)
(view all)
106       NKAETAAKHGEAQVK     PLMD
113       KHGEAQVKIWRRSYD     PLMD
138       PFYSNISKDRRYADL     PLMD
157       LPSCESLKDTIARAL     PLMD
176       EEIVPQIKEGKRVLI     PLMD
179       VPQIKEGKRVLIAAH     PLMD
Sumoylation
(count: 1)
100       GGLTGLNKAETAAKH     PLMD
Malonylation
(count: 2)
113       KHGEAQVKIWRRSYD     PLMD
39        PAGHEEAKRGGQALR     PLMD
Succinylation
(count: 3)
113       KHGEAQVKIWRRSYD     PLMD
176       EEIVPQIKEGKRVLI     PLMD
5         ***MAAYKLVLIRHG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
O15264P18669IntAct
P05067P18669IntAct
P12004P18669MINT
P12956P18669HPRD; IntAct; MINT
P18669P49703HPRD; IntAct; MINT
P18669P63104MINT
P18669Q14203HPRD; IntAct; MINT
P18669Q15051IntAct
P18669Q99569HPRD; IntAct; MINT