P18666

※ Protein Information

Tag	Content
UniProt Accession	ML12B_RAT; P18666;
Entrez ID	50685
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Myosin regulatory light chain 12B (Myosin RLC-B) (Myosin regulatory light chain 2-B, smooth muscle isoform) (MLC-2) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2)
Gene Name	Myl12b; Mrlc2; Mrlcb; Mylc2b
Organism	Rattus norvegicus
NCBI Taxa ID	10116
Functional Description	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Functional Description Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Sequence (Fasta)	MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS 60 LGKNPTDAYL DAMMNEAPGR INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE 120 DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DD 173 Fasta Sequence >P18666\|Myl12b; Mrlc2; Mrlcb; Mylc2b\|Rattus norvegicus (Rat) MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGRINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	C6 glioma		U		15905959
1	[Reference]: Here we show that MRLC-interacting protein (MIR)-interacting saposin-like protein (MSAP) enhances cell spreading in fibroblasts and migration of rat C6 glioma cells through increases in MRLC phosphorylation.

PTM	Modification Sites
Phosphorylation (count: 2)	19 KKRPQRATSNVFAMF dbPAF 20 KRPQRATSNVFAMFD dbPAF