P18206

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession VINC_HUMAN; P18206;
Entrez ID 7414
GenBank Protein ID NM_003373.3; NM_014000.2;
GenBank Nucleotide ID NP_003364.1; NP_054706.1;
Protein Name Vinculin (Metavinculin) (MV)
Gene Name VCL
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionActin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Sequence
(Fasta)
MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVRVGKE 60
TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARDYLID GSRGILSGTS 120
DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV VETMEDLVTY TKNLGPGMTK MAKMIDERQQ 180
ELTHQEHRVM LVNSMNTVKE LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE 240
INEIIRVLQL TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPSAS PGDAGEQAIR 300
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGSSPVAM QKAQQVSQGL 360
DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG GPEGEEQIRG ALAEARKIAE 420
LCDDPKERDD ILRSLGEISA LTSKLADLRR QGKGDSPEAR ALAKQVATAL QNLQTKTNRA 480
VANSRPAKAA VHLEGKIEQA QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD 540
LLAKCDRVDQ LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKARMQEA MTQEVSDVFS 600
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGKL GATAEKAAAV GTANKSTVEG 660
IQASVKTARE LTPQVVSAAR ILLRNPGNQA AYEHFETMKN QWIDNVEKMT GLVDEAIDTK 720
SLLDASEEAI KKDLDKCKVA MANIQPQMLV AGATSIARRA NRILLVAKRE VENSEDPKFR 780
EAVKAASDEL SKTISPMVMD AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP 840
DFPPPPPDLE QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM 900
AARQLHDEAR KWSSKPGIPA AEVGIGVVAE ADAADAAGFP VPPDMEDDYE PELLLMPSNQ 960
PVNQPILAAA QSLHREATKW SSKGNDIIAA AKRMALLMAE MSRLVRGGSG TKRALIQCAK 1020
DIAKASDEVT RLAKEVAKQC TDKRIRTNLL QVCERIPTIS TQLKILSTVK ATMLGRTNIS 1080
DEESEQATEM LVHNAQNLMQ SVKETVREAE AASIKIRTDA GFTLRWVRKT PWYQ 1135

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationLeukemiaP3130982
[Reference]: Role of protein kinase C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)
MESH:D054058 ; Acute Coronary Syndrome
MESH:C566954 ; Cardiomyopathy, Dilated, 1w
MESH:C567681 ; Cardiomyopathy, Familial Hypertrophic, 15
MESH:D010024 ; Osteoporosis
HGMD
(count: 1)
CM062022; Cardiomyopathy, hypertrophic; Missense/nonsense
GWASdb
(count: 12)
(view all)
rs7914469; Premature ovarian failure; premature ovarian failure
rs4745730; Alzheimer's disease; Alzheimer's disease
rs4745730; Premature ovarian failure; premature ovarian failure
rs4745730; Aortic root size; cardiovascular system disease
rs4414157; Premature ovarian failure; premature ovarian failure
rs17743339; Coronary Artery Disease; coronary artery disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 57)
(view all)
100       QMLQSDPYSVPARDY     dbPAF
101       MLQSDPYSVPARDYL     dbPAF
1060      CERIPTISTQLKILS     dbPAF
1061      ERIPTISTQLKILST     dbPAF
107       YSVPARDYLIDGSRG     dbPAF
1080      MLGRTNISDEESEQA     dbPAF
Acetylation
(count: 16)
(view all)
1020      RALIQCAKDIAKASD     PLMD
1024      QCAKDIAKASDEVTR     PLMD
173       PGMTKMAKMIDERQQ     PLMD
276       ALASIDSKLNQAKGW     PLMD
316       VGELCAGKERREILG     PLMD
326       REILGTCKMLGQMTD     PLMD
Ubiquitination
(count: 28)
(view all)
1024      QCAKDIAKASDEVTR     PLMD
1034      DEVTRLAKEVAKQCT     PLMD
1064      PTISTQLKILSTVKA     PLMD
1070      LKILSTVKATMLGRT     PLMD
1115      EAEAASIKIRTDAGF     PLMD
199       VNSMNTVKELLPVLI     PLMD
Glycation
(count: 11)
(view all)
1024      QCAKDIAKASDEVTR     PLMD
488       VANSRPAKAAVHLEG     PLMD
59        SNLVRVGKETVQTTE     PLMD
607       SDTTTPIKLLAVAAT     PLMD
639       NFENHSGKLGATAEK     PLMD
646       KLGATAEKAAAVGTA     PLMD
Malonylation
(count: 14)
(view all)
1020      RALIQCAKDIAKASD     PLMD
1024      QCAKDIAKASDEVTR     PLMD
170       NLGPGMTKMAKMIDE     PLMD
173       PGMTKMAKMIDERQQ     PLMD
228       QGIEEALKNRNFTVE     PLMD
316       VGELCAGKERREILG     PLMD
Succinylation
(count: 3)
1020      RALIQCAKDIAKASD     PLMD
71        TTEDQILKRDMPPAF     PLMD
992       NDIIAAAKRMALLMA     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource