Tag | Content |
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UniProt Accession | VINC_HUMAN; P18206; |
Entrez ID | 7414 |
GenBank Protein ID | NM_003373.3; NM_014000.2; |
GenBank Nucleotide ID | NP_003364.1; NP_054706.1; |
Protein Name | Vinculin (Metavinculin) (MV) |
Gene Name | VCL |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. |
Sequence (Fasta) | MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVRVGKE 60 TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARDYLID GSRGILSGTS 120 DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV VETMEDLVTY TKNLGPGMTK MAKMIDERQQ 180 ELTHQEHRVM LVNSMNTVKE LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE 240 INEIIRVLQL TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPSAS PGDAGEQAIR 300 QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGSSPVAM QKAQQVSQGL 360 DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG GPEGEEQIRG ALAEARKIAE 420 LCDDPKERDD ILRSLGEISA LTSKLADLRR QGKGDSPEAR ALAKQVATAL QNLQTKTNRA 480 VANSRPAKAA VHLEGKIEQA QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD 540 LLAKCDRVDQ LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKARMQEA MTQEVSDVFS 600 DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGKL GATAEKAAAV GTANKSTVEG 660 IQASVKTARE LTPQVVSAAR ILLRNPGNQA AYEHFETMKN QWIDNVEKMT GLVDEAIDTK 720 SLLDASEEAI KKDLDKCKVA MANIQPQMLV AGATSIARRA NRILLVAKRE VENSEDPKFR 780 EAVKAASDEL SKTISPMVMD AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP 840 DFPPPPPDLE QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM 900 AARQLHDEAR KWSSKPGIPA AEVGIGVVAE ADAADAAGFP VPPDMEDDYE PELLLMPSNQ 960 PVNQPILAAA QSLHREATKW SSKGNDIIAA AKRMALLMAE MSRLVRGGSG TKRALIQCAK 1020 DIAKASDEVT RLAKEVAKQC TDKRIRTNLL QVCERIPTIS TQLKILSTVK ATMLGRTNIS 1080 DEESEQATEM LVHNAQNLMQ SVKETVREAE AASIKIRTDA GFTLRWVRKT PWYQ 1135 |
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Database | Annotation |
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CTD (Curated) (count: 4) | MESH:D054058
; Acute Coronary Syndrome MESH:C566954 ; Cardiomyopathy, Dilated, 1w MESH:C567681 ; Cardiomyopathy, Familial Hypertrophic, 15 MESH:D010024 ; Osteoporosis |
HGMD (count: 1) | CM062022; Cardiomyopathy, hypertrophic; Missense/nonsense
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GWASdb (count: 12) (view all) | rs7914469; Premature ovarian failure; premature ovarian failure
rs4745730; Alzheimer's disease; Alzheimer's disease rs4745730; Premature ovarian failure; premature ovarian failure rs4745730; Aortic root size; cardiovascular system disease rs4414157; Premature ovarian failure; premature ovarian failure rs17743339; Coronary Artery Disease; coronary artery disease |
PTM | Modification Sites |
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Phosphorylation (count: 57) (view all) | 100 QMLQSDPYSVPARDY dbPAF
101 MLQSDPYSVPARDYL dbPAF 1060 CERIPTISTQLKILS dbPAF 1061 ERIPTISTQLKILST dbPAF 107 YSVPARDYLIDGSRG dbPAF 1080 MLGRTNISDEESEQA dbPAF |
Acetylation (count: 16) (view all) | 1020 RALIQCAKDIAKASD PLMD
1024 QCAKDIAKASDEVTR PLMD 173 PGMTKMAKMIDERQQ PLMD 276 ALASIDSKLNQAKGW PLMD 316 VGELCAGKERREILG PLMD 326 REILGTCKMLGQMTD PLMD |
Ubiquitination (count: 28) (view all) | 1024 QCAKDIAKASDEVTR PLMD
1034 DEVTRLAKEVAKQCT PLMD 1064 PTISTQLKILSTVKA PLMD 1070 LKILSTVKATMLGRT PLMD 1115 EAEAASIKIRTDAGF PLMD 199 VNSMNTVKELLPVLI PLMD |
Glycation (count: 11) (view all) | 1024 QCAKDIAKASDEVTR PLMD
488 VANSRPAKAAVHLEG PLMD 59 SNLVRVGKETVQTTE PLMD 607 SDTTTPIKLLAVAAT PLMD 639 NFENHSGKLGATAEK PLMD 646 KLGATAEKAAAVGTA PLMD |
Malonylation (count: 14) (view all) | 1020 RALIQCAKDIAKASD PLMD
1024 QCAKDIAKASDEVTR PLMD 170 NLGPGMTKMAKMIDE PLMD 173 PGMTKMAKMIDERQQ PLMD 228 QGIEEALKNRNFTVE PLMD 316 VGELCAGKERREILG PLMD |
Succinylation (count: 3) | 1020 RALIQCAKDIAKASD PLMD
71 TTEDQILKRDMPPAF PLMD 992 NDIIAAAKRMALLMA PLMD |
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