P17947

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SPI1_HUMAN; P17947;
Entrez ID 6688
GenBank Protein ID NM_001080547.1; NM_003120.2;
GenBank Nucleotide ID NP_001074016.1; NP_003111.2;
Protein Name Transcription factor PU.1 (31 kDa-transforming protein)
Gene Name SPI1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionBinds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).
Sequence
(Fasta)		MLQACKMEGF PLVPPPSEDL VPYDTDLYQR QTHEYYPYLS SDGESHSDHY WDFHPHHVHS 60
EFESFAENNF TELQSVQPPQ LQQLYRHMEL EQMHVLDTPM VPPHPSLGHQ VSYLPRMCLQ 120
YPSLSPAQPS SDEEEGERQS PPLEVSDGEA DGLEPGPGLL PGETGSKKKI RLYQFLLDLL 180
RSGDMKDSIW WVDKDKGTFQ FSSKHKEALA HRWGIQKGNR KKMTYQKMAR ALRNYGKTGE 240
VKKVKKKLTY QFSGEVLGRG GLAERRHPPH 271

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationAcute myeloid leukaemia/Acute myelogenous leukemiaP10745625
[Reference]: Protein expression and constitutive phosphorylation of hematopoietic transcription factors PU.1 and C/EBP beta in acute myeloid leukemia blasts

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D007951 ; Leukemia, Myeloid
MESH:D015470 ; Leukemia, Myeloid, Acute
MESH:D054218 ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
GWASdb
(count: 3)		rs140541052; Venous thrombosis; Null
rs140541052; Thrombin generation potential phenotypes; blood protein disease
rs10769258; Schizophrenia; schizophrenia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 140       EEEGERQSPPLEVSD     dbPAF
146       QSPPLEVSDGEADGL     dbPAF
17        FPLVPPPSEDLVPYD     dbPAF
Glycation
(count: 2)		 237       RALRNYGKTGEVKKV     PLMD
242       YGKTGEVKKVKKKLT     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource