| Tag | Content |
|---|---|
| UniProt Accession | DDX5_HUMAN; P17844; |
| Entrez ID | 1655 |
| GenBank Protein ID | NM_001320595.1; NM_001320596.1; NM_004396.4; |
| GenBank Nucleotide ID | NP_001307524.1; NP_001307525.1; NP_004387.1; |
| Protein Name | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) |
| Gene Name | DDX5; G17P1; HELR; HLR1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 tr(view all) |
| Sequence (Fasta) | MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ 60 EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI 120 QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA 180 QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR 240 RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI 300 NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK 360 MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN 420 SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS 480 GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY 540 TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA 600 APMIGYPMPT GYSQ 615 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | prostate |
| CTD (Curated) (count: 1) | MESH:D004715 ; Endometriosis |
| DisGeNet (Curated) (count: 1) | C0014175; Endometriosis |
| HGMD (count: 1) | CM066777; Fibrosis risk, assoc. with; Missense/nonsense |
| GWASdb (count: 4) | rs2075552; Height; Null
rs6504237; Height; Null rs16947824; Alcohol and nictotine co-dependence; alcohol dependence|nicotine dependence rs16947824; Telomere length; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 35) (view all) | 198 CRACRLKSTCIYGGA dbPAF
199 RACRLKSTCIYGGAP dbPAF 2 ******MSGYSSDRD dbPAF 202 RLKSTCIYGGAPKGP dbPAF 224 GVEICIATPGRLIDF dbPAF 24 GAPRFGGSRAGPLSG dbPAF |
| Acetylation (count: 23) (view all) | 197 YCRACRLKSTCIYGG PLMD
207 CIYGGAPKGPQIRDL PLMD 236 IDFLECGKTNLRRTT PLMD 264 GFEPQIRKIVDQIRP PLMD 284 MWSATWPKEVRQLAE PLMD 32 RAGPLSGKKFGNPGE PLMD |
| Ubiquitination (count: 23) (view all) | 197 YCRACRLKSTCIYGG PLMD
207 CIYGGAPKGPQIRDL PLMD 236 IDFLECGKTNLRRTT PLMD 264 GFEPQIRKIVDQIRP PLMD 284 MWSATWPKEVRQLAE PLMD 340 MEEIMSEKENKTIVF PLMD |
| Sumoylation (count: 11) (view all) | 343 IMSEKENKTIVFVET PLMD
388 DWVLNEFKHGKAPIL PLMD 391 LNEFKHGKAPILIAT PLMD 40 KFGNPGEKLVKKKWN PLMD 411 GLDVEDVKFVINYDY PLMD 437 GRTARSTKTGTAYTF PLMD |
| Malonylation (count: 3) | 207 CIYGGAPKGPQIRDL PLMD
264 GFEPQIRKIVDQIRP PLMD 391 LNEFKHGKAPILIAT PLMD |
| Methylation (count: 1) | 56 DELPKFEKNFYQEHP PLMD |
| Phosphoglycerylation (count: 1) | 91 VRGHNCPKPVLNFYE PLMD |