| Tag | Content |
|---|---|
| UniProt Accession | UBF1_HUMAN; P17480; |
| Entrez ID | 7343 |
| GenBank Protein ID | NM_001076683.1; NM_001076684.2; NM_014233.3; XM_006722059.3; XM_006722060.2; XM_006722061.2; XM_017025003.1; XM_017025004.1; |
| GenBank Nucleotide ID | NP_001070151.1; NP_001070152.1; NP_055048.1; XP_006722122.1; XP_006722123.1; XP_006722124.1; XP_016880492.1; XP_016880493.1; |
| Protein Name | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) |
| Gene Name | UBTF; UBF; UBF1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. |
| Sequence (Fasta) | MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE SHMDWEKVAF 60 KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY KGKKLKKHPD FPKKPLTPYF 120 RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKQ EFERNLARFR 180 EDHPDLIQNA KKSDIPEKPK TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK 240 KRLKWIHKAL EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP 300 PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK KKDYEVELLR 360 FLESLPEEEQ QRVLGEEKML NINKKQATSP ASKKPAQEGG KGGSEKPKRP VSAMFIFSEE 420 KRRQLQEERP ELSESELTRL LARMWNDLSE KKKAKYKARE AALKAQSERK PGGEREERGK 480 LPESPKRAEE IWQQSVIGDY LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR 540 YERELSEMRA PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI 600 GSRWQRISQS QKEHYKKLAE EQQKQYKVHL DLWVKSLSPQ DRAAYKEYIS NKRKSMTKLR 660 GPNPKSSRTT LQSKSESEED DEEDEDDEDE DEEEEDDENG DSSEDGGDSS ESSSEDESED 720 GDENEEDDED EDDDEDDDED EDNESEGSSS SSSSSGDSSD SDSN 765 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 6) | rs2071167; Coronary artery disease; coronary artery disease
rs2269906; Multiple complex diseases; Null rs2269906; Red blood cell traits; hematopoietic system disease rs2269906; Self-reported allergy; hypersensitivity reaction disease rs2269905; Red blood cell traits; hematopoietic system disease rs2269905; Self-reported allergy; hypersensitivity reaction disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 34) (view all) | 117 DFPKKPLTPYFRFFM dbPAF
147 LDLTKILSKKYKELP dbPAF 150 TKILSKKYKELPEKK dbPAF 201 DIPEKPKTPQQLWYT dbPAF 207 KTPQQLWYTHEKKVY dbPAF 208 TPQQLWYTHEKKVYL dbPAF |
| Acetylation (count: 22) (view all) | 114 KHPDFPKKPLTPYFR PLMD
132 EKRAKYAKLHPEMSN PLMD 266 IMRDYIQKHPELNIS PLMD 279 ISEEGITKSTLTKAE PLMD 284 ITKSTLTKAERQLKD PLMD 299 KFDGRPTKPPPNSYS PLMD |
| Ubiquitination (count: 38) (view all) | 114 KHPDFPKKPLTPYFR PLMD
126 YFRFFMEKRAKYAKL PLMD 132 EKRAKYAKLHPEMSN PLMD 144 MSNLDLTKILSKKYK PLMD 151 KILSKKYKELPEKKK PLMD 160 LPEKKKMKYIQDFQR PLMD |
| Sumoylation (count: 7) (view all) | 114 KHPDFPKKPLTPYFR PLMD
160 LPEKKKMKYIQDFQR PLMD 279 ISEEGITKSTLTKAE PLMD 284 ITKSTLTKAERQLKD PLMD 378 QRVLGEEKMLNINKK PLMD 45 LPSNDSSKFKTTESH PLMD |
| Methylation (count: 2) | 232 EVKDSLGKQWSQLSD PLMD
254 HKALEQRKEYEEIMR PLMD |