P17325

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession JUN_RAT; P17325;
Entrez ID 24516
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog)
Gene Name Jun; Rjg-9
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells.
Sequence
(Fasta)		MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGNLK PHLRAKNSDL 60
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 120
LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA 180
LSSGGGAPSY GATGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG 240
ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST 300
ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF 335

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationAlzheimer's diseaseUS6323474850
[Reference]: Amyloid precursor protein phosphorylation is markedly enhanced in the CA3 region of rats with long-term oestrogen deprivation after ischaemic stress
2Serine PhosphorylationAlzheimer's diseaseAS7323474850
[Reference]: Amyloid precursor protein phosphorylation is markedly enhanced in the CA3 region of rats with long-term oestrogen deprivation after ischaemic stress

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 20)
(view all)		MESH:D001171 ; Arthritis, Juvenile
MESH:D001930 ; Brain Injuries
MESH:D002545 ; Brain Ischemia
MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D002471 ; Cell Transformation, Neoplastic

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 6)		 242       VPEMPGETPPLSPID     dbPAF
246       PGETPPLSPIDMESQ     dbPAF
252       LSPIDMESQERIKAE     dbPAF
62        AKNSDLLTSPDVGLL     dbPAF
63        KNSDLLTSPDVGLLK     dbPAF
73        VGLLKLASPELERLI     dbPAF