Tag | Content |
---|---|
UniProt Accession | KPCA_HUMAN; P17252; |
Entrez ID | 5578 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) |
Gene Name | PRKCA; PKCA; PRKACA |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation(view all) |
Sequence (Fasta) | MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120 LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA 180 KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240 SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300 LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360 TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420 NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480 DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540 EDEDELFQSI MEHNVSYPKS LSKEAVSVCK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600 DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660 PQFVHPILQS AV 673 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 6) | MESH:D059366
; Asthma, Occupational MESH:D006332 ; Cardiomegaly MESH:D018500 ; Diabetes Insipidus, Nephrogenic MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D007414 ; Intestinal Neoplasms MESH:D011141 ; Polyuria |
GWASdb (count: 52) (view all) | rs9912468; Ventricular conduction; heart conduction disease
rs17634425; Pancreatic cancer; pancreatic cancer rs4417581; Cortisol secretion, in saliva; mental depression rs4790911; Meningococcal disease; Waterhouse-Friderichsen syndrome rs4790911; Cortisol secretion, in saliva; mental depression rs16959238; Amyotrophic Lateral Sclerosis; amyotrophic lateral sclerosis |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 35) (view all) | 10 DVFPGNDSTASQDVA dbPAF
109 HKFKIHTYGSPTFCD dbPAF 11 VFPGNDSTASQDVAN dbPAF 111 FKIHTYGSPTFCDHC dbPAF 113 IHTYGSPTFCDHCGS dbPAF 13 PGNDSTASQDVANRF dbPAF |
Acetylation (count: 7) (view all) | 158 CGMDHTEKRGRIYLK PLMD
172 KAEVADEKLHVTVRD PLMD 316 KLGPAGNKVISPSED PLMD 570 KEAVSVCKGLMTKHP PLMD 575 VCKGLMTKHPAKRLG PLMD 604 FRRIDWEKLENREIQ PLMD |
Ubiquitination (count: 17) (view all) | 141 TCDMNVHKQCVINVP PLMD
158 CGMDHTEKRGRIYLK PLMD 165 KRGRIYLKAEVADEK PLMD 172 KAEVADEKLHVTVRD PLMD 199 SDPYVKLKLIPDPKN PLMD 309 RQKFEKAKLGPAGNK PLMD |
Malonylation (count: 2) | 172 KAEVADEKLHVTVRD PLMD
617 IQPPFKPKVCGKGAE PLMD |