P16949

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession STMN1_HUMAN; P16949;
Entrez ID 3925
GenBank Protein ID NM_001145454.2; NM_005563.3; NM_203399.1; NM_203401.1;
GenBank Nucleotide ID NP_001138926.1; NP_005554.1; NP_981944.1; NP_981946.1;
Protein Name Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)
Gene Name STMN1; C1orf215; LAP18; OP18
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInvolved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Sequence
(Fasta)		MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER 60
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 120
ERLREKDKHI EEVRKNKESK DPADETEAD

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationBreast cancer/tumor/carcinomaDS1621768358
[Reference]: Siva1 inhibits stathmin's activity directly as well as indirectly through Ca(2+)/calmodulin-dependent protein kinase II-mediated phosphorylation of stathmin at Ser16. Via the inhibition of stathmin, Siva1 enhances the formation of microtubules and impedes focal adhesion assembly, cell migration, and EMT. Low levels of Siva1 and Ser16-phosphorylated stathmin correlate with high metastatic states of human breast cancer cells.?
2Serine PhosphorylationFanconi anaemiaDS1626466335
[Reference]: We also showed that FANCC is required for STMN1 phosphorylation, as mutations in FANCC reduced serine 16- and 38-phosphorylated forms of STMN1. Phosphorylation of STMN1 at serine 16 is likely an event dependent on a functional FA pathway, as it is reduced in FANCA- and FANCD2-mutant cells.?
3Serine PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaPS2526505358
[Reference]: Construction of a hepatocellular carcinoma cell line that stably expresses stathmin with a Ser25 phosphorylation site mutation.
4Serine PhosphorylationSchizophreniaUS2516925597
[Reference]: Increased in some schizophrenic patients; decreased in patients with Alzheimer's disease
5Serine PhosphorylationAlzheimer's diseaseUS2516925597
[Reference]: Increased in some schizophrenic patients; decreased in patients with Alzheimer's disease
6Serine PhosphorylationFanconi anaemiaDS3826466335
[Reference]: We also showed that FANCC is required for STMN1 phosphorylation, as mutations in FANCC reduced serine 16- and 38-phosphorylated forms of STMN1.
7Serine PhosphorylationEndometrial cancer/carcinomatumor tissuePS3823538402
[Reference]: High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition
8Serine PhosphorylationSchizophreniaUS3816925597
[Reference]: Increased in some schizophrenic patients; not significantly changed in patients with the Alzheimer's disease
9Serine PhosphorylationAlzheimer's diseaseUS3816925597
[Reference]: Increased in some schizophrenic patients; not significantly changed in patients with the Alzheimer's disease
10Serine PhosphorylationBreast cancer/tumor/carcinomaUS3827130664
[Reference]: We report that phosphorylation of STMN1 at Ser25 and Ser38 is necessary to maintain cell migration capabilities and is associated with shorter disease-free survival (DFS) in breast cancer. In addition, we report that glucose-regulated protein of molecular mass 78 (GRP78) is a novel phospho-STMN1 binding protein upon STMN1 Ser25/Ser38 phosphorylation.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:D001943 ; Breast Neoplasms
MESH:D002277 ; Carcinoma
MESH:D005910 ; Glioma
MESH:D015674 ; Mammary Neoplasms, Animal
MESH:D008325 ; Mammary Neoplasms, Experimental
MESH:D011471 ; Prostatic Neoplasms
DisGeNet (Curated)
(count: 7)
(view all)		C0011570; Mental Depression
C0011581; Depressive disorder
C0017638; Glioma
C0024667; Animal Mammary Neoplasms
C0024668; Mammary Neoplasms, Experimental
C0033578; Prostatic Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 102       KMAEEKLTHKMEANK     dbPAF
139       EVRKNKESKDPADET     dbPAF
146       SKDPADETEAD****     dbPAF
16        KELEKRASGQAFELI     dbPAF
25        QAFELILSPRSKESV     dbPAF
28        ELILSPRSKESVPEF     dbPAF
Acetylation
(count: 14)
(view all)		 100       FSKMAEEKLTHKMEA     PLMD
104       AEEKLTHKMEANKEN     PLMD
119       REAQMAAKLERLREK     PLMD
126       KLERLREKDKHIEEV     PLMD
128       ERLREKDKHIEEVRK     PLMD
137       IEEVRKNKESKDPAD     PLMD
Ubiquitination
(count: 15)
(view all)		 100       FSKMAEEKLTHKMEA     PLMD
119       REAQMAAKLERLREK     PLMD
128       ERLREKDKHIEEVRK     PLMD
137       IEEVRKNKESKDPAD     PLMD
140       VRKNKESKDPADETE     PLMD
29        LILSPRSKESVPEFP     PLMD
Methylation
(count: 1)		 29        LILSPRSKESVPEFP     PLMD
Succinylation
(count: 2)		 52        LSLEEIQKKLEAAEE     PLMD
9         ASSDIQVKELEKRAS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource