| Tag | Content |
|---|---|
| UniProt Accession | FER_HUMAN; P16591; |
| Entrez ID | 2241 |
| GenBank Protein ID | NM_001308028.1; NM_001308031.1; NM_001308038.1; NM_005246.3; XM_011543271.2; XM_017009230.1; XM_017009231.1; |
| GenBank Nucleotide ID | NP_001294957.1; NP_001294960.1; NP_001294967.1; NP_005237.2; XP_011541573.1; XP_016864719.1; XP_016864720.1; |
| Protein Name | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) |
| Gene Name | FER; TYK3 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts (view all) |
| Sequence (Fasta) | MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKESTVQ 60 MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSYIGVHQQ 120 IEAEMIKVTK TELEKLKCSY RQLIKEMNSA KEKYKEALAK GKETEKAKER YDKATMKLHM 180 LHNQYVLALK GAQLHQNQYY DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI 240 VNVHKEIQMS VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL 300 TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI VLLLSQKQAL 360 EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV NYEEDARSVT SMERKERLSK 420 FESIRHSIAG IIRSPKSALG SSALSDMISI SEKPLAEQDW YHGAIPRIEA QELLKKQGDF 480 LVRESHGKPG EYVLSVYSDG QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK 540 KSGVVLLNPI PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE 600 LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR RKKDELKLKQ 660 LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI SDFGMSRQED GGVYSSSGLK 720 QIPIKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGVCP YPGMTNQQAR EQVERGYRMS 780 APQHCPEDIS KIMMKCWDYK PENRPKFSEL QKELTIIKRK LT 823 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 12) (view all) | rs2900035; Monocyte chemoattractant protein-1; obesity
rs13177718; Height; Null rs10073668; Lung function (forced expiratory volume in 1 second to forced vital capacity ratio); lung disease rs17472083; Bipolar disorder, affective; bipolar disorder rs10515396; Coronary Artery Disease; coronary artery disease rs11955321; Post-operative nausea and vomiting; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 28) (view all) | 113 DKQQVKKSYIGVHQQ dbPAF
114 KQQVKKSYIGVHQQI dbPAF 199 AQLHQNQYYDITLPL dbPAF 200 QLHQNQYYDITLPLL dbPAF 229 LKGIFDEYSQITSLV dbPAF 27 WELRLLETVKKFMAL dbPAF |
| Acetylation (count: 2) | 610 IKFLQEAKILKQYDH PLMD
725 GLKQIPIKWTAPEAL PLMD |
| Ubiquitination (count: 7) (view all) | 476 EAQELLKKQGDFLVR PLMD
594 SVAVKTCKEDLPQEL PLMD 602 EDLPQELKIKFLQEA PLMD 610 IKFLQEAKILKQYDH PLMD 613 LQEAKILKQYDHPNI PLMD 699 VGENNVLKISDFGMS PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |