P16422

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	EPCAM_HUMAN; P16422;
Entrez ID	4072
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Ma
Gene Name	EPCAM; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. Functional Description May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Sequence (Fasta)	MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS VGAQNTVICS 60 KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD ESGLFKAKQC NGTSMCWCVN 120 TAGVRRTDKD TEITCSERVR TYWIIIELKH KAREKPYDSK SLRTALQKEI TTRYQLDPKF 180 ITSILYENNV ITIDLVQNSS QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL 240 DLDPGQTLIY YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 300 EIKEMGEMHR ELNA 315 Fasta Sequence >P16422\|EPCAM; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1\|Homo sapiens (Human) MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Glycosylation	Breast cancer/tumor/carcinoma		P		23988446
1	[Reference]: Expression of EpCAM and ERAP2 in vitro in the presence of dog pancreas rough microsomes (ER vesicles) confirmed N-linked glycosylation, processing in ER and the size of EpCAM. The association between ERAP2 and EpCAM is a unique and novel finding that provides new ideas on EpCAM processing and on how antigen presentation may be regulated in?cancer

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 11) (view all)	MESH:D002277 ; Carcinoma MESH:C567685 ; Colorectal Cancer, Hereditary Nonpolyposis, Type 8 MESH:D003123 ; Colorectal Neoplasms, Hereditary Nonpolyposis MESH:C567703 ; Diarrhea 5, With Tufting Enteropathy, Congenital MESH:D008106 ; Liver Cirrhosis, Experimental MESH:C537261 ; Lynch syndrome I (site-specific colonic cancer) MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D010051 ; Ovarian Neoplasms MESH:D010190 ; Pancreatic Neoplasms MESH:D011471 ; Prostatic Neoplasms
DisGeNet (Curated) (count: 48) (view all)	C0000737; Abdominal Pain C0003467; Anxiety C0007102; Malignant tumor of colon C0009405; Hereditary Nonpolyposis Colorectal Neoplasms C0009806; Constipation C0011581; Depressive disorder C0014544; Epilepsy C0015672; Fatigue C0017181; Gastrointestinal Hemorrhage C0017636; Glioblastoma C0023893; Liver Cirrhosis, Experimental C0024667; Animal Mammary Neoplasms C0024668; Mammary Neoplasms, Experimental C0026826; Muscle Hypertonia C0026827; Muscle hypotonia C0027498; Nausea and vomiting C0030297; Pancreatic Neoplasm C0033578; Prostatic Neoplasms C0034885; Rectal Neoplasms C0036572; Seizures C0149931; Migraine Disorders C0151740; Intracranial Hypertension C0231246; Failure to gain weight C0237326; Dyschezia C0267456; Villous atrophy of intestine C0554101; Villous atrophy C0743178; Diarrhea, intractable C0744641; Intermittent migraine headaches C0919267; ovarian neoplasm C1262477; Weight decreased C1263846; Attention deficit hyperactivity disorder C1333990; Hereditary Nonpolyposis Colorectal Cancer C1833058; Small intestine biopsy shows villous atrophy C1844947; Death in early childhood C1858430; Death in infancy C1859541; Variable degree of villous atrophy C2315100; Pediatric failure to thrive C2677378; Duodenal villous atrophy C2700617; Irritation - emotion C2750471; COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 8 C2750737; DIARRHEA 5, WITH TUFTING ENTEROPATHY, CONGENITAL C2931459; Lynch syndrome I (site-specific colonic cancer) C3714745; Malabsorption C4020747; Biopsy shows villous atrophy C4020884; Anxiety disease C4020899; Autosomal recessive predisposition C4022012; Death in early adulthood C4024989; Hereditary nonpolyposis colorectal carcinoma
HGMD (count: 9) (view all)	CG090545; Colorectal cancer, non-polyposis; Gross deletions CG090542; Colorectal cancer, non-polyposis; Gross deletions CG090003; Colorectal cancer, non-polyposis; Gross deletions CG090002; Colorectal cancer, non-polyposis; Gross deletions CG090544; Colorectal cancer, non-polyposis; Gross deletions CG090543; Colorectal cancer, non-polyposis; Gross deletions CM083785; Congenital tufting enteropathy; Missense/nonsense CS083988; Congenital tufting enteropathy; Splicing CS083989; Congenital tufting enteropathy; Splicing

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 3)	234 HSKKMDLTVNGEQLD dbPAF 247 LDLDPGQTLIYYVDE dbPAF 297 RKKRMAKYEKAEIKE dbPAF
Ubiquitination (count: 5)	168 SLRTALQKEITTRYQ PLMD 218 DVAYYFEKDVKGESL PLMD 291 VVLVISRKKRMAKYE PLMD 299 KRMAKYEKAEIKEMG PLMD 303 KYEKAEIKEMGEMHR PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O95471	P16422	HPRD
P13569	P16422	IntAct
P16422	P16422	HPRD