P16403

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession H12_HUMAN; P16403;
Entrez ID 3006
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)
Gene Name HIST1H1C; H1F2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionHistone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Sequence
(Fasta)		MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA 60
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKV 120
KKAGGTKPKK PVGAAKKPKK AAGGATPKKS AKKTPKKAKK PAAATVTKKV AKSPKKAKVA 180
KPKKAAKSAA KAVKPKAAKP KVVKPKKAAP KKK 214

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationBladder cancerUT14623675690
[Reference]: The relative level of H1 p-T146 in invasive high grade bladder cancer cells (J82, T24, and UMUC3) as compared to the RT4 noninvasive low-grade bladder cancer cell line was 50% higher

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D001943 ; Breast Neoplasms
MESH:D015470 ; Leukemia, Myeloid, Acute
DisGeNet (Curated)
(count: 2)		C0023467; Leukemia, Myelocytic, Acute
C1458155; Mammary Neoplasms
GWASdb
(count: 4)		rs8384; Red blood cell traits; hematopoietic system disease
rs10425; Uric acid levels; gout
rs10425; Urate levels; gout
rs10425; Red blood cell traits; hematopoietic system disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 16)
(view all)		 104       KGTGASGSFKLNKKA     dbPAF
113       KLNKKAASGEAKPKV     dbPAF
126       KVKKAGGTKPKKPVG     dbPAF
146       KKAAGGATPKKSAKK     dbPAF
165       AKKPAAATVTKKVAK     dbPAF
167       KPAAATVTKKVAKSP     dbPAF
Acetylation
(count: 6)		 117       KAASGEAKPKVKKAG     PLMD
159       KKTPKKAKKPAAATV     PLMD
168       PAAATVTKKVAKSPK     PLMD
17        AAAPPAEKAPVKKKA     PLMD
191       KAAKSAAKAVKPKAA     PLMD
34        KAGGTPRKASGPPVS     PLMD
Ubiquitination
(count: 12)
(view all)		 117       KAASGEAKPKVKKAG     PLMD
127       VKKAGGTKPKKPVGA     PLMD
136       KKPVGAAKKPKKAAG     PLMD
140       GAAKKPKKAAGGATP     PLMD
159       KKTPKKAKKPAAATV     PLMD
160       KTPKKAKKPAAATVT     PLMD
Sumoylation
(count: 1)		 17        AAAPPAEKAPVKKKA     PLMD
Crotonylation
(count: 7)
(view all)		 159       KKTPKKAKKPAAATV     PLMD
168       PAAATVTKKVAKSPK     PLMD
34        KAGGTPRKASGPPVS     PLMD
64        VSLAALKKALAAAGY     PLMD
85        SRIKLGLKSLVSKGT     PLMD
90        GLKSLVSKGTLVQTK     PLMD
Glycation
(count: 9)
(view all)		 136       KKPVGAAKKPKKAAG     PLMD
172       TVTKKVAKSPKKAKV     PLMD
175       KKVAKSPKKAKVAKP     PLMD
199       AVKPKAAKPKVVKPK     PLMD
201       KPKAAKPKVVKPKKA     PLMD
21        PAEKAPVKKKAAKKA     PLMD
Methylation
(count: 6)		 119       ASGEAKPKVKKAGGT     PLMD
168       PAAATVTKKVAKSPK     PLMD
187       AKPKKAAKSAAKAVK     PLMD
34        KAGGTPRKASGPPVS     PLMD
52        TKAVAASKERSGVSL     PLMD
75        AAGYDVEKNNSRIKL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource