Tag | Content |
---|---|
UniProt Accession | H12_HUMAN; P16403; |
Entrez ID | 3006 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) |
Gene Name | HIST1H1C; H1F2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
Sequence (Fasta) | MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA 60 ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKV 120 KKAGGTKPKK PVGAAKKPKK AAGGATPKKS AKKTPKKAKK PAAATVTKKV AKSPKKAKVA 180 KPKKAAKSAA KAVKPKAAKP KVVKPKKAAP KKK 214 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 2) | MESH:D001943
; Breast Neoplasms MESH:D015470 ; Leukemia, Myeloid, Acute |
DisGeNet (Curated) (count: 2) | C0023467; Leukemia, Myelocytic, Acute
C1458155; Mammary Neoplasms |
GWASdb (count: 4) | rs8384; Red blood cell traits; hematopoietic system disease
rs10425; Uric acid levels; gout rs10425; Urate levels; gout rs10425; Red blood cell traits; hematopoietic system disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 16) (view all) | 104 KGTGASGSFKLNKKA dbPAF
113 KLNKKAASGEAKPKV dbPAF 126 KVKKAGGTKPKKPVG dbPAF 146 KKAAGGATPKKSAKK dbPAF 165 AKKPAAATVTKKVAK dbPAF 167 KPAAATVTKKVAKSP dbPAF |
Acetylation (count: 6) | 117 KAASGEAKPKVKKAG PLMD
159 KKTPKKAKKPAAATV PLMD 168 PAAATVTKKVAKSPK PLMD 17 AAAPPAEKAPVKKKA PLMD 191 KAAKSAAKAVKPKAA PLMD 34 KAGGTPRKASGPPVS PLMD |
Ubiquitination (count: 12) (view all) | 117 KAASGEAKPKVKKAG PLMD
127 VKKAGGTKPKKPVGA PLMD 136 KKPVGAAKKPKKAAG PLMD 140 GAAKKPKKAAGGATP PLMD 159 KKTPKKAKKPAAATV PLMD 160 KTPKKAKKPAAATVT PLMD |
Sumoylation (count: 1) | 17 AAAPPAEKAPVKKKA PLMD |
Crotonylation (count: 7) (view all) | 159 KKTPKKAKKPAAATV PLMD
168 PAAATVTKKVAKSPK PLMD 34 KAGGTPRKASGPPVS PLMD 64 VSLAALKKALAAAGY PLMD 85 SRIKLGLKSLVSKGT PLMD 90 GLKSLVSKGTLVQTK PLMD |
Glycation (count: 9) (view all) | 136 KKPVGAAKKPKKAAG PLMD
172 TVTKKVAKSPKKAKV PLMD 175 KKVAKSPKKAKVAKP PLMD 199 AVKPKAAKPKVVKPK PLMD 201 KPKAAKPKVVKPKKA PLMD 21 PAEKAPVKKKAAKKA PLMD |
Methylation (count: 6) | 119 ASGEAKPKVKKAGGT PLMD
168 PAAATVTKKVAKSPK PLMD 187 AKPKKAAKSAAKAVK PLMD 34 KAGGTPRKASGPPVS PLMD 52 TKAVAASKERSGVSL PLMD 75 AAGYDVEKNNSRIKL PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |