| Tag | Content |
|---|---|
| UniProt Accession | H15_HUMAN; P16401; |
| Entrez ID | 3009 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) |
| Gene Name | HIST1H1B; H1F5 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
| Sequence (Fasta) | MSETAPAETA TPAPVEKSPA KKKATKKAAG AGAAKRKATG PPVSELITKA VAASKERNGL 60 SLAALKKALA AGGYDVEKNN SRIKLGLKSL VSKGTLVQTK GTGASGSFKL NKKAASGEAK 120 PKAKKAGAAK AKKPAGATPK KAKKAAGAKK AVKKTPKKAK KPAAAGVKKV AKSPKKAKAA 180 AKPKKATKSP AKPKAVKPKA AKPKAAKPKA AKPKAAKAKK AAAKKK 227 |
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| Database | Annotation |
|---|---|
| DisGeNet (Curated) (count: 1) | C0036341; Schizophrenia |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 18) (view all) | 107 KGTGASGSFKLNKKA dbPAF
11 TAPAETATPAPVEKS dbPAF 138 AKKPAGATPKKAKKA dbPAF 155 AKKAVKKTPKKAKKP dbPAF 173 GVKKVAKSPKKAKAA dbPAF 18 TPAPVEKSPAKKKAT dbPAF |
| Acetylation (count: 11) (view all) | 160 KKTPKKAKKPAAAGV PLMD
168 KPAAAGVKKVAKSPK PLMD 17 ATPAPVEKSPAKKKA PLMD 199 KPKAVKPKAAKPKAA PLMD 202 AVKPKAAKPKAAKPK PLMD 204 KPKAAKPKAAKPKAA PLMD |
| Ubiquitination (count: 9) (view all) | 161 KTPKKAKKPAAAGVK PLMD
168 KPAAAGVKKVAKSPK PLMD 17 ATPAPVEKSPAKKKA PLMD 21 PVEKSPAKKKATKKA PLMD 22 VEKSPAKKKATKKAA PLMD 37 GAGAAKRKATGPPVS PLMD |
| Glycation (count: 1) | 67 LSLAALKKALAAGGY PLMD |
| Malonylation (count: 3) | 17 ATPAPVEKSPAKKKA PLMD
37 GAGAAKRKATGPPVS PLMD 78 AGGYDVEKNNSRIKL PLMD |
| Methylation (count: 2) | 27 AKKKATKKAAGAGAA PLMD
37 GAGAAKRKATGPPVS PLMD |
| Succinylation (count: 1) | 66 GLSLAALKKALAAGG PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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