| Tag | Content |
|---|---|
| UniProt Accession | CREB1_HUMAN; P16220; |
| Entrez ID | 1385 |
| GenBank Protein ID | NM_004379.4; NM_134442.4; XM_011510645.1; XM_011510647.2; |
| GenBank Nucleotide ID | NP_004370.1; NP_604391.1; XP_011508947.1; XP_011508949.1; |
| Protein Name | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) |
| Gene Name | CREB1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. |
| Sequence (Fasta) | MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 60 GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD 120 SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG 180 QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV 240 VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 300 RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D 342 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | clear cell sarcoma, angiomatoid fibrous histiocytoma |
| CTD (Curated) (count: 5) | MESH:D019970
; Cocaine-Related Disorders MESH:C563181 ; Histiocytoma, Angiomatoid Fibrous MESH:D009021 ; Morphine Dependence MESH:D009203 ; Myocardial Infarction MESH:D013375 ; Substance Withdrawal Syndrome |
| DisGeNet (Curated) (count: 16) (view all) | C0001973; Alcoholic Intoxication, Chronic
C0005586; Bipolar Disorder C0011570; Mental Depression C0011581; Depressive disorder C0026552; Morphine Dependence C0027051; Myocardial Infarction |
| HGMD (count: 1) | CR083279; Increased promoter activity, association with; Regulatory
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| GWASdb (count: 2) | rs2254137; Opioid sensitivity; drug dependence
rs1806584; Type 2 diabetes and 6 quantitative traits; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 17) (view all) | 100 LKRLFSGTQISTIAE dbPAF
108 QISTIAESEDSQESV dbPAF 111 TIAESEDSQESVDSV dbPAF 114 ESEDSQESVDSVTDS dbPAF 117 DSQESVDSVTDSQKR dbPAF 119 QESVDSVTDSQKRRE dbPAF |
| Acetylation (count: 3) | 136 SRRPSYRKILNDLSS PLMD
91 QTVQSSCKDLKRLFS PLMD 94 QSSCKDLKRLFSGTQ PLMD |
| Ubiquitination (count: 7) (view all) | 136 SRRPSYRKILNDLSS PLMD
304 ARECRRKKKEYVKCL PLMD 309 RKKKEYVKCLENRVA PLMD 323 AVLENQNKTLIEELK PLMD 330 KTLIEELKALKDLYC PLMD 333 IEELKALKDLYCHKS PLMD |
| Sumoylation (count: 2) | 285 PAEEAARKREVRLMK PLMD
304 ARECRRKKKEYVKCL PLMD |