P16144

※ Protein Information

Tag	Content
UniProt Accession	ITB4_HUMAN; P16144;
Entrez ID	3691
GenBank Protein ID	NM_000213.4; NM_001005619.1; NM_001005731.2; NM_001321123.1;
GenBank Nucleotide ID	NP_000204.3; NP_001005619.1; NP_001005731.1; NP_001308052.1;
Protein Name	Integrin beta-4 (GP150) (CD antigen CD104)
Gene Name	ITGB4
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). Functional Description Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Sequence (Fasta)	MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR 60 CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL 120 EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV 180 PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL 240 QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR 300 TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE 360 EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG 420 THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV 480 CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN 540 FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR 600 CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE 660 LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL 720 LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR 780 SGNLKGRDVV RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC 840 AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK 900 LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI RPEDDDEKQL 960 LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS VSRGDQVARI PVIRRVLDGG 1020 KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH 1080 VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS 1140 RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG 1200 AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV 1260 NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP 1320 KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTG CGWKFEPLLG 1380 EELDLRRVTW RLPPELIPRL SASSGRSSDA EAPHGPPDDG GAGGKGGSLP RSATPGPPGE 1440 HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH 1500 SHSTTLPRDY STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY 1560 SVEYQLLNGG ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES 1620 QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM 1680 AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG 1740 PFPQLGSRAG LFQHPLQSEY SSITTTHTSA TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF 1800 VSRTLTTSGT LSTHMDQQFF QT 1823 Fasta Sequence >P16144\|ITGB4\|Homo sapiens (Human) MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Serine Phosphorylation	Squamous cell carcinoma	U	S1356	21769085
1	[Reference]: Phosphorylation of the 4 integrin is increased in human SCC
2	Tyrosine Phosphorylation	Breast cancer/tumor/carcinoma	U	Y1564	20855525
2	[Reference]: SHP2 mediates the localized activation of Fyn downstream of the ?6?4 integrin to promote carcinoma invasion.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 11) (view all)	MESH:D000022 ; Abortion, Spontaneous MESH:D003528 ; Carcinoma, Adenoid Cystic MESH:D004476 ; Ectodermal Dysplasia MESH:D004820 ; Epidermolysis Bullosa MESH:D016109 ; Epidermolysis Bullosa, Junctional MESH:C562639 ; Epidermolysis Bullosa, Junctional, Non-Herlitz Type MESH:D016110 ; Epidermolysis Bullosa Simplex MESH:C535377 ; Epidermolysis bullosa with pyloric atresia MESH:D005911 ; Gliosis MESH:C562561 ; Pyloric Atresia MESH:D012468 ; Salivary Gland Neoplasms
DisGeNet (Curated) (count: 76) (view all)	C0000731; Abdomen distended C0000786; Spontaneous abortion C0002871; Anemia C0003886; Arthrogryposis C0010606; Adenoid Cystic Carcinoma C0011168; Deglutition Disorders C0011175; Dehydration C0011334; Dental caries C0011351; Dental Enamel Hypoplasia C0013575; Ectodermal Dysplasia C0013592; Ectropion C0014527; Epidermolysis Bullosa C0014850; Esophageal Atresia C0017639; Gliosis C0020224; Polyhydramnios C0020295; Hydronephrosis C0020608; Hypodontia C0021828; Intestinal Atresia C0027498; Nausea and vomiting C0036095; Salivary Gland Neoplasms C0036690; Septicemia C0041960; Ureterocele C0041974; Urethral Stricture C0042063; Urogenital Abnormalities C0079298; Epidermolysis Bullosa Simplex C0079301; Junctional Epidermolysis Bullosa C0080276; Disorder of the genitourinary system C0151526; Premature Birth C0162119; Hemoglobin low C0162154; Atrophic scar C0178664; Glomerulosclerosis (disorder) C0221260; Dystrophia unguium C0231246; Failure to gain weight C0233315; Premature birth of newborn C0241181; Fragile skin C0265989; Congenital scar C0265998; ANONYCHIA C0266159; Pyloric Atresia C0266298; Accessory kidney C0268374; Adult junctional epidermolysis bullosa (disorder) C0282160; Aplasia Cutis Congenita C0345996; Milium Cyst C0409348; Flexion contracture of proximal interphalangeal joint C0740927; Elevated maternal serum alpha-fetoprotein C0743178; Diarrhea, intractable C0853945; Oral mucosal blistering C1260926; Abnormal pigmentation C1619700; RENAL ADYSPLASIA C1834405; Nail dysplasia C1844738; Axillary pterygia C1844947; Death in early childhood C1851854; Thin dental enamel C1853193; Recurrent skin infections C1856934; Epidermolysis bullosa with pyloric atresia C1856953; Palmar hyperhidrosis C1856954; Plantar hyperkeratosis C1856963; Fragile nails C1857108; Decreased joint mobility C1858430; Death in infancy C1862863; Sparse body hair C2315100; Pediatric failure to thrive C2677349; Epidermolysis Bullosa Simplex With Pyloric Atresia C2752013; Prenatal onset C3536714; Renal dysplasia C3806301; Scarring alopecia of scalp C3887524; Skin Erosion C4020895; Genitourinary dysplasia C4020899; Autosomal recessive predisposition C4021730; Junctional split C4023812; Aplasia of the bladder C4024876; Palmoplantar blistering C4025327; Congenital pyloric atresia C4025699; Abnormality of the stomach C4280456; Dysplasia of tooth enamel C4280457; Defective enamel matrix C4280623; Rotting teeth
HGMD (count: 69) (view all)	CD064566; Epidermolysis bullosa with pyloric atresia; Small deletions CD068388; Epidermolysis bullosa with pyloric atresia; Small deletions CD086025; Epidermolysis bullosa with pyloric atresia; Small deletions CD033711; Epidermolysis bullosa with pyloric atresia; Small deletions CD073651; Epidermolysis bullosa with pyloric atresia; Small deletions CD068389; Epidermolysis bullosa with pyloric atresia; Small deletions CD068390; Epidermolysis bullosa with pyloric atresia; Small deletions CD056462; Epidermolysis bullosa with pyloric atresia; Small deletions CD982716; Epidermolysis bullosa with pyloric atresia; Small deletions CD011869; Epidermolysis bullosa with pyloric atresia; Small deletions CD056463; Epidermolysis bullosa with pyloric atresia; Small deletions CD035101; Epidermolysis bullosa with pyloric atresia; Small deletions CD023269; Epidermolysis bullosa simplex; Small deletions CD061431; Epidermolysis bullosa, junctional; Small deletions CD014143; Epidermolysis bullosa with pyloric atresia; Small deletions CD982714; Epidermolysis bullosa with pyloric atresia; Small deletions CD972283; Epidermolysis bullosa with pyloric atresia; Small deletions CD951755; Epidermolysis bullosa with pyloric atresia; Small deletions CD087615; Desquamative enteropathy with pyloric atresia; Small deletions CD011870; Epidermolysis bullosa with pyloric atresia; Small deletions CD982715; Epidermolysis bullosa with pyloric atresia; Small deletions CD982713; Epidermolysis bullosa with pyloric atresia; Small deletions CD972284; Epidermolysis bullosa with pyloric atresia; Small deletions CG045021; Epidermolysis bullosa with pyloric atresia; Gross deletions CG082371; Epidermolysis bullosa with pyloric atresia; Gross deletions CX011900; Epidermolysis bullosa with pyloric atresia; Small indels CI035107; Epidermolysis bullosa with pyloric atresia; Small insertions CI044822; Epidermolysis bullosa with pyloric atresia; Small insertions CI087046; Epidermolysis bullosa with pyloric atresia; Small insertions CI951945; Epidermolysis bullosa; Small insertions CM981084; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM064059; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981085; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981086; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM011789; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981087; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981088; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM064061; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981089; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM011790; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM011791; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM011792; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM011793; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM031224; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM044646; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981090; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981091; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM984199; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM064062; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM073149; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981092; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM064058; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM001197; Epidermolysis bullosa, without pyloric atresia; Missense/nonsense CM011794; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM086837; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981093; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM064060; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM981094; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM086836; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CM015828; Epidermolysis bullosa with pyloric atresia; Missense/nonsense CS014129; Epidermolysis bullosa with pyloric atresia; Splicing CS067098; Epidermolysis bullosa with pyloric atresia; Splicing CS068391; Epidermolysis bullosa with pyloric atresia; Splicing CS011838; Epidermolysis bullosa with pyloric atresia; Splicing CS064421; Epidermolysis bullosa with pyloric atresia; Splicing CS971778; Epidermolysis bullosa with pyloric atresia; Splicing CS992243; Epidermolysis bullosa with pyloric atresia; Splicing CS087047; Epidermolysis bullosa with pyloric atresia; Splicing CS086024; Epidermolysis bullosa with pyloric atresia; Splicing
GWASdb (count: 1)	rs820164; HDL cholesterol; cholesterol ester storage disease\|cholesterol embolism\|coronary artery disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 116) (view all)	1000 SFEQPEFSVSRGDQV dbPAF 102 TLRRSQMSPQGLRVR dbPAF 1039 TAQGNRDYIPVEGEL dbPAF 1069 LELQEVDSLLRGRQV dbPAF 1084 RRFHVQLSNPKFGAH dbPAF 1097 AHLGQPHSTTIIIRD dbPAF 1098 HLGQPHSTTIIIRDP dbPAF 1099 LGQPHSTTIIIRDPD dbPAF 1111 DPDELDRSFTSQMLS dbPAF 1140 PNAKAAGSRKIHFNW dbPAF 1187 SVELTNLYPYCDYEM dbPAF 1189 ELTNLYPYCDYEMKV dbPAF 1199 YEMKVCAYGAQGEGP dbPAF 1207 GAQGEGPYSSLVSCR dbPAF 1208 AQGEGPYSSLVSCRT dbPAF 1209 QGEGPYSSLVSCRTH dbPAF 1246 SWAEPAETNGEITAY dbPAF 1257 ITAYEVCYGLVNDDN dbPAF 1297 ESQPYRYTVKARNGA dbPAF 1318 EAIINLATQPKRPMS dbPAF 1325 TQPKRPMSIPIIPDI dbPAF 1339 IPIVDAQSGEDYDSF dbPAF 1343 DAQSGEDYDSFLMYS dbPAF 1345 QSGEDYDSFLMYSDD dbPAF 1349 DYDSFLMYSDDVLRS dbPAF 1350 YDSFLMYSDDVLRSP dbPAF 1356 YSDDVLRSPSGSQRP dbPAF 1358 DDVLRSPSGSQRPSV dbPAF 1360 VLRSPSGSQRPSVSD dbPAF 1364 PSGSQRPSVSDDTGC dbPAF 1366 GSQRPSVSDDTGCGW dbPAF 1403 LIPRLSASSGRSSDA dbPAF 1404 IPRLSASSGRSSDAE dbPAF 1428 GAGGKGGSLPRSATP dbPAF 1434 GSLPRSATPGPPGEH dbPAF 1454 MDFAFPGSTNSLHRM dbPAF 1455 DFAFPGSTNSLHRMT dbPAF 1457 AFPGSTNSLHRMTTT dbPAF 1465 LHRMTTTSAAAYGTH dbPAF 1469 TTTSAAAYGTHLSPH dbPAF 1471 TSAAAYGTHLSPHVP dbPAF 1474 AAYGTHLSPHVPHRV dbPAF 1483 HVPHRVLSTSSTLTR dbPAF 1484 VPHRVLSTSSTLTRD dbPAF 1485 PHRVLSTSSTLTRDY dbPAF 1486 HRVLSTSSTLTRDYN dbPAF 1487 RVLSTSSTLTRDYNS dbPAF 1489 LSTSSTLTRDYNSLT dbPAF 1492 SSTLTRDYNSLTRSE dbPAF 1494 TLTRDYNSLTRSEHS dbPAF 1496 TRDYNSLTRSEHSHS dbPAF 1498 DYNSLTRSEHSHSTT dbPAF 1501 SLTRSEHSHSTTLPR dbPAF 1503 TRSEHSHSTTLPRDY dbPAF 1504 RSEHSHSTTLPRDYS dbPAF 1505 SEHSHSTTLPRDYST dbPAF 1510 STTLPRDYSTLTSVS dbPAF 1511 TTLPRDYSTLTSVSS dbPAF 1512 TLPRDYSTLTSVSSH dbPAF 1514 PRDYSTLTSVSSHDS dbPAF 1515 RDYSTLTSVSSHDSR dbPAF 1517 YSTLTSVSSHDSRLT dbPAF 1518 STLTSVSSHDSRLTA dbPAF 1521 TSVSSHDSRLTAGVP dbPAF 1524 SSHDSRLTAGVPDTP dbPAF 1530 LTAGVPDTPTRLVFS dbPAF 1532 AGVPDTPTRLVFSAL dbPAF 1542 VFSALGPTSLRVSWQ dbPAF 1543 FSALGPTSLRVSWQE dbPAF 1564 LQGYSVEYQLLNGGE dbPAF 1595 EDLLPNHSYVFRVRA dbPAF 1596 DLLPNHSYVFRVRAQ dbPAF 1604 VFRVRAQSQEGWGRE dbPAF 1653 PLVFTALSPDSLQLS dbPAF 1674 PNGDIVGYLVTCEMA dbPAF 1688 AQGGGPATAFRVDGD dbPAF 1696 AFRVDGDSPESRLTV dbPAF 1707 RLTVPGLSENVPYKF dbPAF 1712 GLSENVPYKFKVQAR dbPAF 1720 KFKVQARTTEGFGPE dbPAF 1721 FKVQARTTEGFGPER dbPAF 1758 LFQHPLQSEYSSITT dbPAF 1760 QHPLQSEYSSITTTH dbPAF 1761 HPLQSEYSSITTTHT dbPAF 1762 PLQSEYSSITTTHTS dbPAF 1764 QSEYSSITTTHTSAT dbPAF 1765 SEYSSITTTHTSATE dbPAF 1766 EYSSITTTHTSATEP dbPAF 1771 TTTHTSATEPFLVDG dbPAF 179 GKFVDKVSVPQTDMR dbPAF 1791 QHLEAGGSLTRHVTQ dbPAF 1793 LEAGGSLTRHVTQEF dbPAF 1797 GSLTRHVTQEFVSRT dbPAF 1804 TQEFVSRTLTTSGTL dbPAF 1806 EFVSRTLTTSGTLST dbPAF 1807 FVSRTLTTSGTLSTH dbPAF 21 LAALISVSLSGTLAN dbPAF 368 EAFNRIRSNLDIRAL dbPAF 377 LDIRALDSPRGLRTE dbPAF 383 DSPRGLRTEVTSKMF dbPAF 387 GLRTEVTSKMFQKTR dbPAF 50 RVDKDCAYCTDEMFR dbPAF 681 RDEDDDCTYSYTMEG dbPAF 7 *MAGPRPSPWARLLL dbPAF 818 NPTELVPYGLSLRLA dbPAF 821 ELVPYGLSLRLARLC dbPAF 829 LRLARLCTENLLKPD dbPAF 837 ENLLKPDTRECAQLR dbPAF 855 EENLNEVYRQISGVH dbPAF 886 QDHTIVDTVLMAPRS dbPAF 920 DLKVAPGYYTLTADQ dbPAF 921 LKVAPGYYTLTADQD dbPAF 922 KVAPGYYTLTADQDA dbPAF 971 AIDVPAGTATLGRRL dbPAF 973 DVPAGTATLGRRLVN dbPAF 982 GRRLVNITIIKEQAR dbPAF
Ubiquitination (count: 20) (view all)	1021 RRVLDGGKSQVSYRT PLMD 1055 FQPGEAWKELQVKLL PLMD 1060 AWKELQVKLLELQEV PLMD 1160 KPMGYRVKYWIQGDS PLMD 1713 LSENVPYKFKVQART PLMD 173 DYTIGFGKFVDKVSV PLMD 177 GFGKFVDKVSVPQTD PLMD 191 DMRPEKLKEPWPNSD PLMD 204 SDPPFSFKNVISLTE PLMD 219 DVDEFRNKLQGERIS PLMD 388 LRTEVTSKMFQKTRT PLMD 437 QKGNIHLKPSFSDGL PLMD 656 EECNFKVKMVDELKR PLMD 662 VKMVDELKRAEEVVV PLMD 758 RGHMVGFKEDHYMLR PLMD 785 MLRSGNLKGRDVVRW PLMD 895 LMAPRSAKPALLKLT PLMD 904 ALLKLTEKQVEQRAF PLMD 915 QRAFHDLKVAPGYYT PLMD 958 RPEDDDEKQLLVEAI PLMD
Sumoylation (count: 1)	437 QKGNIHLKPSFSDGL PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

A8K7I4	P16144	HPRD
E7ESA6	P16144	HPRD
E9PHM6	P16144	HPRD
G5E9H1	P16144	HPRD
P04626	P16144	HPRD
P05413	P16144	IntAct
P06241	P16144	HPRD
P07947	P16144	HPRD
P08581	P16144	HPRD
P08670	P16144	HPRD
P12004	P16144	BioGRID
P16144	P17252	HPRD
P16144	P18054	HPRD; IntAct
P16144	P21333	MINT
P16144	P23229	IntAct
P16144	P27348	HPRD
P16144	P28482	BioGRID
P16144	P29353	HPRD
P16144	P31946	HPRD
P16144	P54253	HPRD; IntAct; MINT
P16144	P56537	HPRD
P16144	P62993	HPRD
P16144	Q05655	HPRD
P16144	Q12772	IntAct
P16144	Q15149	HPRD
P16144	Q15796	IntAct
P16144	Q96B67	IntAct
P16144	Q96RT1	HPRD
P16144	Q9BY67	IntAct
P16144	Q9UMD9	HPRD
P16144	Q9UQC9	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction