| Tag | Content |
|---|---|
| UniProt Accession | H2AX_HUMAN; P16104; |
| Entrez ID | 3014 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Histone H2AX (H2a/x) (Histone H2A.X) |
| Gene Name | H2AFX; H2AX |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
| Sequence (Fasta) | MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT 60 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK 120 TSATVGPKAP SGGKKATQAS QEY 144 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 6) | MESH:D001943
; Breast Neoplasms MESH:D019457 ; Chromosome Breakage MESH:D005909 ; Glioblastoma MESH:D048629 ; Micronuclei, Chromosome-Defective MESH:D009364 ; Neoplasm Recurrence, Local MESH:D011123 ; Polyploidy |
| DisGeNet (Curated) (count: 7) (view all) | C0017636; Glioblastoma
C0027643; Neoplasm Recurrence, Local C0032578; Polyploidy C0036341; Schizophrenia C0376628; Chromosome Breakage C1449861; Micronuclei, Chromosome-Defective |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 102 NKLLGGVTIAQGGVL dbPAF
121 AVLLPKKTSATVGPK dbPAF 122 VLLPKKTSATVGPKA dbPAF 124 LPKKTSATVGPKAPS dbPAF 131 TVGPKAPSGGKKATQ dbPAF 137 PSGGKKATQASQEY* dbPAF |
| Acetylation (count: 6) | 10 GRGKTGGKARAKAKS PLMD
134 PKAPSGGKKATQASQ PLMD 135 KAPSGGKKATQASQE PLMD 16 GKARAKAKSRSSRAG PLMD 6 **MSGRGKTGGKARA PLMD 96 RNDEELNKLLGGVTI PLMD |
| Ubiquitination (count: 6) | 119 IQAVLLPKKTSATVG PLMD
120 QAVLLPKKTSATVGP PLMD 128 TSATVGPKAPSGGKK PLMD 134 PKAPSGGKKATQASQ PLMD 135 KAPSGGKKATQASQE PLMD 96 RNDEELNKLLGGVTI PLMD |
| Sumoylation (count: 2) | 119 IQAVLLPKKTSATVG PLMD
135 KAPSGGKKATQASQE PLMD |
| Butyrylation (count: 1) | 6 **MSGRGKTGGKARA PLMD |
| Methylation (count: 1) | 134 PKAPSGGKKATQASQ PLMD |