Tag | Content |
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UniProt Accession | MUC1_HUMAN; P15941; |
Entrez ID | 4582 |
GenBank Protein ID | NM_001018016.2; NM_001018017.2; NM_001044390.2; NM_001044391.2; NM_001044392.2; NM_001044393.2; NM_001204285.1; NM_001204286.1; NM_001204287.1; NM_001204288.1; NM_001204289.1; NM_001204290.1; NM_001204291.1; NM_001204292.1; NM_001204293.1; NM_001204294.1; NM_001204295.1; NM_001204296.1; NM_001204297.1; NM_002456.5; |
GenBank Nucleotide ID | NP_001018016.1; NP_001018017.1; NP_001037855.1; NP_001037856.1; NP_001037857.1; NP_001037858.1; NP_001191214.1; NP_001191215.1; NP_001191216.1; NP_001191217.1; NP_001191218.1; NP_001191219.1; NP_001191220.1; NP_001191221.1; NP_001191222.1; NP_001191223.1; NP_001191224.1; NP_001191225.1; NP_001191226.1; NP_002447.4; |
Protein Name | Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (T |
Gene Name | MUC1; PUM |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.;The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
Sequence (Fasta) | MTPGTQSPFF LLLLLTVLTV VTGSGHASST PGGEKETSAT QRSSVPSSTE KNAVSMTSSV 60 LSSHSPGSGS STTQGQDVTL APATEPASGS AATWGQDVTS VPVTRPALGS TTPPAHDVTS 120 APDNKPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 180 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 240 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 300 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 360 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 420 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 480 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 540 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 600 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 660 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 720 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 780 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 840 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 900 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDNRPALGS TAPPVHNVTS 960 ASGSASGSAS TLVHNGTSAR ATTTPASKST PFSIPSHHSD TPTTLASHST KTDASSTHHS 1020 SVPPLTSSNH STSPQLSTGV SFFFLSFHIS NLQFNSSLED PSTDYYQELQ RDISEMFLQI 1080 YKQGGFLGLS NIKFRPGSVV VQLTLAFREG TINVHDVETQ FNQYKTEAAS RYNLTISDVS 1140 VSDVPFPFSA QSGAGVPGWG IALLVLVCVL VALAIVYLIA LAVCQCRRKN YGQLDIFPAR 1200 DTYHPMSEYP TYHTHGRYVP PSSTDRSPYE KVSAGNGGSS LSYTNPAVAA TSANL 1256 |
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Database | Annotation |
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Cancer Gene Census | B-NHL |
CTD (Curated) (count: 7) (view all) | MESH:D002471
; Cell Transformation, Neoplastic MESH:C536137 ; Medullary cystic kidney disease 1 MESH:D008654 ; Mesothelioma MESH:C562839 ; Mesothelioma, Malignant MESH:D009101 ; Multiple Myeloma MESH:D010534 ; Peritoneal Neoplasms |
DisGeNet (Curated) (count: 29) (view all) | C0002871; Anemia
C0003868; Arthritis, Gouty C0007621; Neoplastic Cell Transformation C0018099; Gout C0020538; Hypertensive disease C0020649; Hypotension |
GWASdb (count: 3) | rs4072037; magnesium levels; disorder of magnesium metabolism|magnesium deficiency
rs4072037; Esophageal cancer and gastric cancer; esophageal cancer|stomach cancer rs4072037; Urate levels; gout |
PTM | Modification Sites |
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Phosphorylation (count: 22) (view all) | 1191 CQCRRKNYGQLDIFP dbPAF
1202 DIFPARDTYHPMSEY dbPAF 1203 IFPARDTYHPMSEYP dbPAF 1207 RDTYHPMSEYPTYHT dbPAF 1209 TYHPMSEYPTYHTHG dbPAF 1211 HPMSEYPTYHTHGRY dbPAF |
Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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