Tag | Content |
---|---|
UniProt Accession | RFA2_HUMAN; P15927; |
Entrez ID | 6118 |
GenBank Protein ID | NM_001286076.1; NM_001297558.1; NM_002946.4; |
GenBank Nucleotide ID | NP_001273005.1; NP_001284487.1; NP_002937.1; |
Protein Name | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) |
Gene Name | RPA2; REPA2; RPA32; RPA34 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of (view all) |
Sequence (Fasta) | MWNSGFESYG SSSYGGAGGY TQSPGGFGSP APSQAEKKSR ARAQHIVPCT ISQLLSATLV 60 DEVFRIGNVE ISQVTIVGII RHAEKAPTNI VYKIDDMTAA PMDVRQWVDT DDTSSENTVV 120 PPETYVKVAG HLRSFQNKKS LVAFKIMPLE DMNEFTTHIL EVINAHMVLS KANSQPSAGR 180 APISNPGMSE AGNFGGNSFM PANGLTVAQN QVLNLIKACP RPEGLNFQDL KNQLKHMSVS 240 SIKQAVDFLS NEGHIYSTVD DDHFKSTDAE 271 |
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Database | Annotation |
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GWASdb (count: 5) | rs3766396; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease
rs2295367; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease rs6679432; Smoking initiation; nicotine dependence rs2474470; Smoking initiation; nicotine dependence rs6700473; Smoking initiation; nicotine dependence |
PTM | Modification Sites |
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Phosphorylation (count: 23) (view all) | 11 SGFESYGSSSYGGAG dbPAF
114 WVDTDDTSSENTVVP dbPAF 115 VDTDDTSSENTVVPP dbPAF 118 DDTSSENTVVPPETY dbPAF 12 GFESYGSSSYGGAGG dbPAF 13 FESYGSSSYGGAGGY dbPAF |
Acetylation (count: 3) | 139 LRSFQNKKSLVAFKI PLMD
231 GLNFQDLKNQLKHMS PLMD 93 APTNIVYKIDDMTAA PLMD |
Ubiquitination (count: 7) (view all) | 127 VPPETYVKVAGHLRS PLMD
171 NAHMVLSKANSQPSA PLMD 231 GLNFQDLKNQLKHMS PLMD 235 QDLKNQLKHMSVSSI PLMD 243 HMSVSSIKQAVDFLS PLMD 85 GIIRHAEKAPTNIVY PLMD |