P15924

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	DESP_HUMAN; P15924;
Entrez ID	1832
GenBank Protein ID	NM_001008844.2; NM_001319034.1; NM_004415.3;
GenBank Nucleotide ID	NP_001008844.1; NP_001305963.1; NP_004406.2;
Protein Name	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene Name	DSP
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Functional Description Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Sequence (Fasta)	MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD QNSDGYCQTG 60 TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ LTRSRELDEC FAQANDQMEI 120 LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR ALYKAISVPR VRRASSKGGG GYTCQSGSGW 180 DEFTKHVTSE CLGWMRQQRA EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA 240 DLREKSAIYQ LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD 300 KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY MDTLQTQWSW 360 ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR KKYPCDKNMP LQHLLEQIKE 420 LEKEREKILE YKRQVQNLVN KSKKIVQLKP RNPDYRSNKP IILRALCDYK QDQKIVHKGD 480 ECILKDNNER SKWYVTGPGG VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL 540 YINMKSLVSW HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF 600 GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN HNKVIETNRE 660 NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH HITVKINELK SVQNDSQAIA 720 EVLNQLKDML ANFRGSEKYC YLQNEVFGLF QKLENINGVT DGYLNSLCTV RALLQAILQT 780 EDMLKVYEAR LTEEETVCLD LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS 840 QTSQQYPLYD LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK 900 WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI AELCANSIKD 960 YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH ARYIELLTRS GDYYRFLSEM 1020 LKSLEDLKLK NTKIEVLEEE LRLARDANSE NCNKNKFLDQ NLQKYQAECS QFKAKLASLE 1080 ELKRQAELDG KSAKQNLDKC YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD 1140 QLQKARQCEK ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKVRNHYN 1200 EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD RLSRENRDLK DEIVRLNDSI 1260 LQATEQRRRA EENALQQKAC GSEIMQKKQH LEIELKQVMQ QRSEDNARHK QSLEEAAKTI 1320 QDKNKEIERL KAEFQEEAKR RWEYENELSK VRNNYDEEII SLKNQFETEI NITKTTIHQL 1380 TMQKEEDTSG YRAQIDNLTR ENRSLSEEIK RLKNTLTQTT ENLRRVEEDI QQQKATGSEV 1440 SQRKQQLEVE LRQVTQMRTE ESVRYKQSLD DAAKTIQDKN KEIERLKQLI DKETNDRKCL 1500 EDENARLQRV QYDLQKANSS ATETINKLKV QEQELTRLRI DYERVSQERT VKDQDITRFQ 1560 NSLKELQLQK QKVEEELNRL KRTASEDSCK RKKLEEELEG MRRSLKEQAI KITNLTQQLE 1620 QASIVKKRSE DDLRQQRDVL DGHLREKQRT QEELRRLSSE VEALRRQLLQ EQESVKQAHL 1680 RNEHFQKAIE DKSRSLNESK IEIERLQSLT ENLTKEHLML EEELRNLRLE YDDLRRGRSE 1740 ADSDKNATIL ELRSQLQISN NRTLELQGLI NDLQRERENL RQEIEKFQKQ ALEASNRIQE 1800 SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEDELNRAK STLEAETRVK QRLECEKQQI 1860 QNDLNQWKTQ YSRKEEAIRK IESEREKSER EKNSLRSEIE RLQAEIKRIE ERCRRKLEDS 1920 TRETQSQLET ERSRYQREID KLRQRPYGSH RETQTECEWT VDTSKLVFDG LRKKVTAMQL 1980 YECQLIDKTT LDKLLKGKKS VEEVASEIQP FLRGAGSIAG ASASPKEKYS LVEAKRKKLI 2040 SPESTVMLLE AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYAAE KAITGFDDPF 2100 SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS VFLPKDVALA RGLIDRDLYR 2160 SLNDPRDSQK NFVDPVTKKK VSYVQLKERC RIEPHTGLLL LSVQKRSMSF QGIRQPVTVT 2220 ELVDSGILRP STVNELESGQ ISYDEVGERI KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI 2280 GLVRPGTALE LLEAQAATGF IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN 2340 DPETGNIISL FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI AYKRGYFNEE 2400 LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG LCLLPLKEKK KQVQTSQKNT 2460 LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY ETFKELCEQE CEWEEITITG SDGSTRVVLV 2520 DRKTGSQYDI QDAIDKGLVD RKFFDQYRSG SLSLTQFADM ISLKNGVGTS SSMGSGVSDD 2580 VFSSSRHESV SKISTISSVR NLTIRSSSFS DTLEESSPIA AIFDTENLEK ISITEGIERG 2640 IVDSITGQRL LEAQACTGGI IHPTTGQKLS LQDAVSQGVI DQDMATRLKP AQKAFIGFEG 2700 VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE VHGRISTEEA IRKGFIDGRA 2760 AQRLQDTSSY AKILTCPKTK LKISYKDAIN RSMVEDITGL RLLEAASVSS KGLPSPYNMS 2820 SAPGSRSGSR SGSRSGSRSG SRSGSRRGSF DATGNSSYSY SYSFSSSSIG H 2872 Fasta Sequence >P15924\|DSP\|Homo sapiens (Human) MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Arrhythmogenic right ventricular dysplasia		N	S299	12373648
1	[Reference]: Here, we report on a genome scan in one Italian family in which the disease appeared unlinked to any of the six different ARVD loci reported so far; we identify a mutation (S299R) in exon 7 of desmoplakin (DSP), which modifies a putative phosphorylation site in the N-terminal domain binding plakoglobin.
2	Arginine Methylation	Cardiovascular/heart disease		N	R2834	25733715
2	[Reference]: R2834H blocked the GSK3 phosphorylation cascade and reduced DP-GSK3 interactions in cultured keratinocytes and in the hearts of transgenic R2834H DP mice.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 10) (view all)	MESH:C564400 ; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8 MESH:C535581 ; Cardiomyopathy dilated with Woolly hair and keratoderma OMIM:615821 ; CARDIOMYOPATHY, DILATED, WITH WOOLLY HAIR, KERATODERMA, AND TOOTH AGENESIS MESH:D016757 ; Death, Sudden, Cardiac MESH:C535493 ; Epidermolysis bullosa, lethal acantholytic MESH:D054990 ; Idiopathic Pulmonary Fibrosis MESH:C565102 ; Keratosis Palmoplantaris Striata II MESH:D029424 ; Pulmonary Disease, Chronic Obstructive MESH:D011658 ; Pulmonary Fibrosis MESH:C564359 ; Skin Fragility-Woolly Hair Syndrome
DisGeNet (Curated) (count: 55) (view all)	C0000887; Acantholysis C0002170; Alopecia C0007193; Cardiomyopathy, Dilated C0007222; Cardiovascular Diseases C0018801; Heart failure C0018802; Congestive heart failure C0022596; Palmoplantar Keratosis C0027339; Nail Diseases C0027443; Natal Teeth C0042510; Ventricular Fibrillation C0042514; Tachycardia, Ventricular C0079153; Hyperkeratosis, Epidermolytic C0085298; Sudden Cardiac Death C0151636; Premature ventricular contractions C0157733; hair abnormalities (non-specific) C0221260; Dystrophia unguium C0231246; Failure to gain weight C0241128; Nikolsky sign C0241181; Fragile skin C0243050; Cardiovascular Abnormalities C0263505; Alopecia universalis C0265998; ANONYCHIA C0343073; Wooly hair C0345326; Congenital phimosis C0410916; Neonatal Death C0853087; Nail abnormality C0853945; Oral mucosal blistering C1800706; Idiopathic Pulmonary Fibrosis C1832446; Sparse eyebrow C1834405; Nail dysplasia C1840069; Sandal gap C1843292; Skin Fragility-Woolly Hair Syndrome C1843294; Palmoplantar keratosis with erythema and scale C1843300; Sparse eyelashes C1843896; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8 C1852127; KERATOSIS PALMOPLANTARIS STRIATA II C1854063; Cardiomyopathy dilated with Woolly hair and keratoderma C1864826; Epidermolysis bullosa, lethal acantholytic C1969236; Pseudosyndactyly C1969237; Tapered distal phalanges C1969238; Widely spaced toes C2063326; Cardiomyopathy, right ventricular C2315100; Pediatric failure to thrive C2677869; Hair shaft abnormalities C2931122; Keratosis palmoplantaris striata 1 C3809719; ERYTHRODERMA, CONGENITAL, WITH PALMOPLANTAR KERATODERMA, HYPOTRICHOSIS, AND HYPER-IgE C3887524; Skin Erosion C4014393; CARDIOMYOPATHY, DILATED, WITH WOOLLY HAIR, KERATODERMA, AND TOOTH AGENESIS C4020899; Autosomal recessive predisposition C4021633; Patchy palmoplantar keratoderma C4024202; Reduced number of teeth C4072835; Kinky hair texture C4072836; Nappy hair texture C4073292; Afro-textured hair C4083050; Agenesis of teeth
GWASdb (count: 8) (view all)	rs9392904; Bipolar disorder; bipolar disorder rs12198780; Neuroticism; anxiety disorder\|mood disorder\|dementia rs10484325; Interstitial lung disease; interstitial lung disease rs10484326; Interstitial lung disease; interstitial lung disease rs2076295; Interstitial lung disease; interstitial lung disease rs1358904; Interstitial lung disease; interstitial lung disease rs3778337; Interstitial lung disease; interstitial lung disease rs2076302; Interstitial lung disease; interstitial lung disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 186) (view all)	1065 LDQNLQKYQAECSQF dbPAF 1101 KQNLDKCYGQIKELN dbPAF 1116 EKITRLTYEIEDEKR dbPAF 1127 DEKRRRKSVEDRFDQ dbPAF 1139 FDQQKNDYDQLQKAR dbPAF 1169 KAIKEKEYEIERLRV dbPAF 1183 VLLQEEGTRKREYEN dbPAF 1188 EGTRKREYENELAKV dbPAF 1199 LAKVRNHYNEEMSNL dbPAF 1220 EINITKTTIKEISMQ dbPAF 1225 KTTIKEISMQKEDDS dbPAF 1259 EIVRLNDSILQATEQ dbPAF 13 GSHPRINTLGRMIRA dbPAF 1319 SLEEAAKTIQDKNKE dbPAF 1361 NYDEEIISLKNQFET dbPAF 1373 FETEINITKTTIHQL dbPAF 1381 KTTIHQLTMQKEEDT dbPAF 1391 KEEDTSGYRAQIDNL dbPAF 1415 EIKRLKNTLTQTTEN dbPAF 1417 KRLKNTLTQTTENLR dbPAF 1420 KNTLTQTTENLRRVE dbPAF 1438 QQQKATGSEVSQRKQ dbPAF 1512 ARLQRVQYDLQKANS dbPAF 1542 LTRLRIDYERVSQER dbPAF 157 RALYKAISVPRVRRA dbPAF 1583 ELNRLKRTASEDSCK dbPAF 1585 NRLKRTASEDSCKRK dbPAF 1613 KEQAIKITNLTQQLE dbPAF 165 VPRVRRASSKGGGGY dbPAF 1658 QEELRRLSSEVEALR dbPAF 1659 EELRRLSSEVEALRR dbPAF 166 PRVRRASSKGGGGYT dbPAF 1708 IEIERLQSLTENLTK dbPAF 1714 QSLTENLTKEHLMLE dbPAF 172 SSKGGGGYTCQSGSG dbPAF 173 SKGGGGYTCQSGSGW dbPAF 176 GGGYTCQSGSGWDEF dbPAF 178 GYTCQSGSGWDEFTK dbPAF 1795 QKQALEASNRIQESK dbPAF 1841 DELNRAKSTLEAETR dbPAF 188 DEFTKHVTSECLGWM dbPAF 189 EFTKHVTSECLGWMR dbPAF 1981 KVTAMQLYECQLIDK dbPAF 2 ****MSCNGGSHP dbPAF 2006 KSVEEVASEIQPFLR dbPAF 2017 PFLRGAGSIAGASAS dbPAF 2022 AGSIAGASASPKEKY dbPAF 2024 SIAGASASPKEKYSL dbPAF 2029 SASPKEKYSLVEAKR dbPAF 2030 ASPKEKYSLVEAKRK dbPAF 2068 PHRNEKLTVDSAIAR dbPAF 2071 NEKLTVDSAIARDLI dbPAF 2087 FDDRQQIYAAEKAIT dbPAF 213 AWGVDLASVEQHINS dbPAF 2159 GLIDRDLYRSLNDPR dbPAF 2161 IDRDLYRSLNDPRDS dbPAF 22 GRMIRAESGPDLRYE dbPAF 2202 HTGLLLLSVQKRSMS dbPAF 2207 LLSVQKRSMSFQGIR dbPAF 2209 SVQKRSMSFQGIRQP dbPAF 2218 QGIRQPVTVTELVDS dbPAF 2220 IRQPVTVTELVDSGI dbPAF 2225 TVTELVDSGILRPST dbPAF 2231 DSGILRPSTVNELES dbPAF 2232 SGILRPSTVNELESG dbPAF 2257 IKDFLQGSSCIAGIY dbPAF 2258 KDFLQGSSCIAGIYN dbPAF 2264 SSCIAGIYNETTKQK dbPAF 227 SHRGIHNSIGDYRWQ dbPAF 2275 TKQKLGIYEAMKIGL dbPAF 231 IHNSIGDYRWQLDKI dbPAF 2316 RLPVEEAYKRGLVGI dbPAF 2339 AERAVTGYNDPETGN dbPAF 2383 GIIDPKESHRLPVDI dbPAF 2402 GYFNEELSEILSDPS dbPAF 2406 EELSEILSDPSDDTK dbPAF 2409 SEILSDPSDDTKGFF dbPAF 246 KADLREKSAIYQLEE dbPAF 2460 VQTSQKNTLRKRRVV dbPAF 2473 VVIVDPETNKEMSVQ dbPAF 2478 PETNKEMSVQEAYKK dbPAF 249 LREKSAIYQLEEEYE dbPAF 2524 VVLVDRKTGSQYDIQ dbPAF 2526 LVDRKTGSQYDIQDA dbPAF 2547 DRKFFDQYRSGSLSL dbPAF 2549 KFFDQYRSGSLSLTQ dbPAF 255 IYQLEEEYENLLKAS dbPAF 2551 FDQYRSGSLSLTQFA dbPAF 2553 QYRSGSLSLTQFADM dbPAF 2555 RSGSLSLTQFADMIS dbPAF 2562 TQFADMISLKNGVGT dbPAF 2569 SLKNGVGTSSSMGSG dbPAF 2570 LKNGVGTSSSMGSGV dbPAF 2571 KNGVGTSSSMGSGVS dbPAF 2572 NGVGTSSSMGSGVSD dbPAF 2575 GTSSSMGSGVSDDVF dbPAF 2578 SSMGSGVSDDVFSSS dbPAF 2583 GVSDDVFSSSRHESV dbPAF 2584 VSDDVFSSSRHESVS dbPAF 2585 SDDVFSSSRHESVSK dbPAF 2589 FSSSRHESVSKISTI dbPAF 2591 SSRHESVSKISTISS dbPAF 2594 HESVSKISTISSVRN dbPAF 2595 ESVSKISTISSVRNL dbPAF 2597 VSKISTISSVRNLTI dbPAF 2598 SKISTISSVRNLTIR dbPAF 2603 ISSVRNLTIRSSSFS dbPAF 2606 VRNLTIRSSSFSDTL dbPAF 2607 RNLTIRSSSFSDTLE dbPAF 2608 NLTIRSSSFSDTLEE dbPAF 2610 TIRSSSFSDTLEESS dbPAF 2612 RSSSFSDTLEESSPI dbPAF 2616 FSDTLEESSPIAAIF dbPAF 2625 PIAAIFDTENLEKIS dbPAF 2632 TENLEKISITEGIER dbPAF 2644 IERGIVDSITGQRLL dbPAF 2670 PTTGQKLSLQDAVSQ dbPAF 2708 VKGKKKMSAAEAVKE dbPAF 2720 VKEKWLPYEAGQRFL dbPAF 2731 QRFLEFQYLTGGLVD dbPAF 2733 FLEFQYLTGGLVDPE dbPAF 2746 PEVHGRISTEEAIRK dbPAF 2785 KTKLKISYKDAINRS dbPAF 2792 YKDAINRSMVEDITG dbPAF 2798 RSMVEDITGLRLLEA dbPAF 28 ESGPDLRYEVTSGGG dbPAF 2807 LRLLEAASVSSKGLP dbPAF 2809 LLEAASVSSKGLPSP dbPAF 2810 LEAASVSSKGLPSPY dbPAF 2815 VSSKGLPSPYNMSSA dbPAF 2817 SKGLPSPYNMSSAPG dbPAF 2820 LPSPYNMSSAPGSRS dbPAF 2821 PSPYNMSSAPGSRSG dbPAF 2825 NMSSAPGSRSGSRSG dbPAF 2827 SSAPGSRSGSRSGSR dbPAF 2829 APGSRSGSRSGSRSG dbPAF 2831 GSRSGSRSGSRSGSR dbPAF 2833 RSGSRSGSRSGSRSG dbPAF 2835 GSRSGSRSGSRSGSR dbPAF 2837 RSGSRSGSRSGSRSG dbPAF 2839 GSRSGSRSGSRSGSR dbPAF 2841 RSGSRSGSRSGSRRG dbPAF 2843 GSRSGSRSGSRRGSF dbPAF 2845 RSGSRSGSRRGSFDA dbPAF 2849 RSGSRRGSFDATGNS dbPAF 2853 RRGSFDATGNSSYSY dbPAF 2856 SFDATGNSSYSYSYS dbPAF 2857 FDATGNSSYSYSYSF dbPAF 2858 DATGNSSYSYSYSFS dbPAF 2859 ATGNSSYSYSYSFSS dbPAF 2861 GNSSYSYSYSFSSSS dbPAF 2866 SYSYSFSSSSIGH dbPAF 2867 YSYSFSSSSIGH* dbPAF 2868 SYSFSSSSIGH** dbPAF 299 EELLYDWSDKNTNIA dbPAF 31 PDLRYEVTSGGGGTS dbPAF 313 AQKQEAFSIRMSQLE dbPAF 317 EAFSIRMSQLEVKEK dbPAF 32 DLRYEVTSGGGGTSR dbPAF 333 LNKLKQESDQLVLNQ dbPAF 37 VTSGGGGTSRMYYSR dbPAF 38 TSGGGGTSRMYYSRR dbPAF 398 YLKGLQDSIRKKYPC dbPAF 41 GGGTSRMYYSRRGVI dbPAF 42 GGTSRMYYSRRGVIT dbPAF 43 GTSRMYYSRRGVITD dbPAF 442 VQNLVNKSKKIVQLK dbPAF 49 YSRRGVITDQNSDGY dbPAF 53 GVITDQNSDGYCQTG dbPAF 56 TDQNSDGYCQTGTMS dbPAF 59 NSDGYCQTGTMSRHQ dbPAF 597 FIRNSQGSEMFGDDD dbPAF 61 DGYCQTGTMSRHQNQ dbPAF 610 DDKRKIQSQFTDAQK dbPAF 613 RKIQSQFTDAQKHYQ dbPAF 698 LPLADQGSSHHITVK dbPAF 699 PLADQGSSHHITVKI dbPAF 7 *MSCNGGSHPRINTL dbPAF 703 QGSSHHITVKINELK dbPAF 79 QELLQNCSDCLMRAE dbPAF 911 DAKRRQDSLESMKFG dbPAF 914 RRQDSLESMKFGDSN dbPAF 944 ISGKRDKSEEVQKIA dbPAF 95 IVQPELKYGDGIQLT dbPAF 957 IAELCANSIKDYELQ dbPAF 961 CANSIKDYELQLASY dbPAF
Acetylation (count: 60) (view all)	1022 RFLSEMLKSLEDLKL PLMD 1028 LKSLEDLKLKNTKIE PLMD 1033 DLKLKNTKIEVLEEE PLMD 1056 SENCNKNKFLDQNLQ PLMD 1064 FLDQNLQKYQAECSQ PLMD 1073 QAECSQFKAKLASLE PLMD 1075 ECSQFKAKLASLEEL PLMD 1083 LASLEELKRQAELDG PLMD 1099 SAKQNLDKCYGQIKE PLMD 1105 DKCYGQIKELNEKIT PLMD 1122 TYEIEDEKRRRKSVE PLMD 1136 EDRFDQQKNDYDQLQ PLMD 1144 NDYDQLQKARQCEKE PLMD 1150 QKARQCEKENLGWQK PLMD 1157 KENLGWQKLESEKAI PLMD 1167 SEKAIKEKEYEIERL PLMD 1209 EMSNLRNKYETEINI PLMD 1228 IKEISMQKEDDSKNL PLMD 1287 CGSEIMQKKQHLEIE PLMD 1384 IHQLTMQKEEDTSGY PLMD 140 QPCDAYQKRLLQLQE PLMD 1492 RLKQLIDKETNDRKC PLMD 1527 SATETINKLKVQEQE PLMD 154 EQMRALYKAISVPRV PLMD 1593 EDSCKRKKLEEELEG PLMD 1687 LRNEHFQKAIEDKSR PLMD 1789 QEIEKFQKQALEASN PLMD 1818 ERESLLVKIKVLEQD PLMD 1857 KQRLECEKQQIQNDL PLMD 1988 YECQLIDKTTLDKLL PLMD 1993 IDKTTLDKLLKGKKS PLMD 2026 AGASASPKEKYSLVE PLMD 2187 KVSYVQLKERCRIEP PLMD 2251 DEVGERIKDFLQGSS PLMD 2317 LPVEEAYKRGLVGIE PLMD 2381 TGGIIDPKESHRLPV PLMD 2393 LPVDIAYKRGYFNEE PLMD 2413 SDPSDDTKGFFDPNT PLMD 2430 NLTYLQLKERCIKDE PLMD 2435 QLKERCIKDEETGLC PLMD 2484 MSVQEAYKKGLIDYE PLMD 2536 DIQDAIDKGLVDRKF PLMD 2542 DKGLVDRKFFDQYRS PLMD 2772 QDTSSYAKILTCPKT PLMD 2786 TKLKISYKDAINRSM PLMD 459 NPDYRSNKPIILRAL PLMD 470 LRALCDYKQDQKIVH PLMD 485 KGDECILKDNNERSK PLMD 689 CEGRMTLKNLPLADQ PLMD 738 ANFRGSEKYCYLQNE PLMD 803 TVCLDLDKVEAYRCG PLMD 829 KSLLATMKTELQKAQ PLMD 855 LYDLDLGKFGEKVTQ PLMD 872 DRWQRIDKQIDFRLW PLMD 900 DNYQAFCKWLYDAKR PLMD 906 CKWLYDAKRRQDSLE PLMD 916 QDSLESMKFGDSNTV PLMD 94 LIVQPELKYGDGIQL PLMD 940 LHSEISGKRDKSEEV PLMD 943 EISGKRDKSEEVQKI PLMD
Ubiquitination (count: 49) (view all)	1022 RFLSEMLKSLEDLKL PLMD 1028 LKSLEDLKLKNTKIE PLMD 1033 DLKLKNTKIEVLEEE PLMD 1056 SENCNKNKFLDQNLQ PLMD 1064 FLDQNLQKYQAECSQ PLMD 1073 QAECSQFKAKLASLE PLMD 1099 SAKQNLDKCYGQIKE PLMD 1209 EMSNLRNKYETEINI PLMD 1250 SRENRDLKDEIVRLN PLMD 1278 EENALQQKACGSEIM PLMD 140 QPCDAYQKRLLQLQE PLMD 154 EQMRALYKAISVPRV PLMD 1564 TRFQNSLKELQLQKQ PLMD 1570 LKELQLQKQKVEEEL PLMD 167 RVRRASSKGGGGYTC PLMD 1802 SNRIQESKNQCTQVV PLMD 185 SGWDEFTKHVTSECL PLMD 1857 KQRLECEKQQIQNDL PLMD 1965 EWTVDTSKLVFDGLR PLMD 1988 YECQLIDKTTLDKLL PLMD 2026 AGASASPKEKYSLVE PLMD 2145 VNSVFLPKDVALARG PLMD 2187 KVSYVQLKERCRIEP PLMD 2251 DEVGERIKDFLQGSS PLMD 2271 YNETTKQKLGIYEAM PLMD 2317 LPVEEAYKRGLVGIE PLMD 2393 LPVDIAYKRGYFNEE PLMD 2413 SDPSDDTKGFFDPNT PLMD 2430 NLTYLQLKERCIKDE PLMD 2435 QLKERCIKDEETGLC PLMD 245 IKADLREKSAIYQLE PLMD 2484 MSVQEAYKKGLIDYE PLMD 2592 SRHESVSKISTISSV PLMD 260 EEYENLLKASFERMD PLMD 2702 FIGFEGVKGKKKMSA PLMD 2811 EAASVSSKGLPSPYN PLMD 449 SKKIVQLKPRNPDYR PLMD 459 NPDYRSNKPIILRAL PLMD 485 KGDECILKDNNERSK PLMD 785 LQTEDMLKVYEARLT PLMD 803 TVCLDLDKVEAYRCG PLMD 829 KSLLATMKTELQKAQ PLMD 855 LYDLDLGKFGEKVTQ PLMD 859 DLGKFGEKVTQLTDR PLMD 872 DRWQRIDKQIDFRLW PLMD 900 DNYQAFCKWLYDAKR PLMD 931 MRFLNEQKNLHSEIS PLMD 94 LIVQPELKYGDGIQL PLMD 949 DKSEEVQKIAELCAN PLMD
Malonylation (count: 5)	1593 EDSCKRKKLEEELEG PLMD 1820 ESLLVKIKVLEQDKA PLMD 1993 IDKTTLDKLLKGKKS PLMD 459 NPDYRSNKPIILRAL PLMD 931 MRFLNEQKNLHSEIS PLMD
Methylation (count: 2)	1802 SNRIQESKNQCTQVV PLMD 727 AEVLNQLKDMLANFR PLMD
Succinylation (count: 3)	1083 LASLEELKRQAELDG PLMD 1410 RSLSEEIKRLKNTLT PLMD 2786 TKLKISYKDAINRSM PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P15924	P19838	MINT
P15924	P33151	HPRD
P15924	P42575	HPRD
P15924	P60510	IntAct
P15924	Q02156	IntAct
P15924	Q13835	HPRD
P15924	Q14164	IntAct; MINT