| Tag | Content |
|---|---|
| UniProt Accession | VAV_HUMAN; P15498; |
| Entrez ID | 7409 |
| GenBank Protein ID | NM_001258207.1; NM_005428.3; |
| GenBank Nucleotide ID | NP_001245136.1; NP_005419.2; |
| Protein Name | Proto-oncogene vav |
| Gene Name | VAV1; VAV |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Sequence (Fasta) | MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 60 NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120 AQNRGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS 180 EPVSMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI 240 EDLLRVHTHF LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA 300 REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA MEKENLRLAL 360 DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM 420 DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ 480 GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 540 YQGYRCHRCR ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF 600 QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF PCNRVKPYVH 660 GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK DAAEFAISIK YNVEVKHIKI 720 MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RTISRPAVGS 780 TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED 840 YSEYC 846 |
|
|||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| Cancer Gene Census | T-cell lymphoma |
| CTD (Curated) (count: 4) | MESH:C538231
; Adenocarcinoma of lung MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D008527 ; Medulloblastoma |
| GWASdb (count: 34) (view all) | rs811292; Major depressive disorder (broad); major depressive disorder
rs479660; Major depressive disorder (broad); major depressive disorder rs568259; Major depressive disorder (broad); major depressive disorder rs2546143; Major depressive disorder (broad); major depressive disorder rs691528; Major depressive disorder (broad); major depressive disorder rs579371; Major depressive disorder (broad); major depressive disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 24) (view all) | 110 QDFGKVIYTLSALSW dbPAF
113 GKVIYTLSALSWTPI dbPAF 142 SVGDEDIYSGLSDQI dbPAF 160 VEEDEDLYDCVENEE dbPAF 174 EAEGDEIYEDLMRSE dbPAF 180 IYEDLMRSEPVSMPP dbPAF |
| Acetylation (count: 8) (view all) | 194 PKMTEYDKRCCCLRE PLMD
222 SIQQHFLKPLQRFLK PLMD 252 RVHTHFLKEMKEALG PLMD 307 AREDVQMKLEECSQR PLMD 435 DKALLICKRRGDSYD PLMD 444 RGDSYDLKDFVNLHS PLMD |
| Ubiquitination (count: 30) (view all) | 188 EPVSMPPKMTEYDKR PLMD
194 PKMTEYDKRCCCLRE PLMD 208 EIQQTEEKYTDTLGS PLMD 222 SIQQHFLKPLQRFLK PLMD 272 NLYQVFIKYKERFLV PLMD 292 SQVESASKHLDRVAA PLMD |