P15407

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession FOSL1_HUMAN; P15407;
Entrez ID 8061
GenBank Protein ID NM_001300844.1; NM_001300855.1; NM_001300856.1; NM_001300857.1; NM_005438.4;
GenBank Nucleotide ID NP_001287773.1; NP_001287784.1; NP_001287785.1; NP_001287786.1; NP_005429.1;
Protein Name Fos-related antigen 1 (FRA-1)
Gene Name FOSL1; FRA1
Organism Homo sapiens
NCBI Taxa ID 9606
Sequence
(Fasta)		MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 60
PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 120
KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE 180
GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST 240
PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L 272

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationBreast cancer/tumor/carcinomaUT21727816489
[Reference]: PKC?-induced phosphorylations, in part at T217 and T227 residues, strongly and specifically increased Fra-1 transcriptional activity through the stimulation of Fra-1 transactivation domain, without affecting JUN factors.
2Serine PhosphorylationColon cancer/carcinomaUS25217371847
[Reference]: Two serines therein, S252 and S265, are phosphorylated by kinases of the Erk1/2 pathway, which compromises protein destruction upon both normal physiological induction and tumorigenic constitutive activation of this cascade.?
3Serine PhosphorylationColon cancer/carcinomaUS26517371847
[Reference]: Two serines therein, S252 and S265, are phosphorylated by kinases of the Erk1/2 pathway, which compromises protein destruction upon both normal physiological induction and tumorigenic constitutive activation of this cascade.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 2)		rs637571; Smoking initiation; nicotine dependence
rs1151523; Smoking initiation; nicotine dependence

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 19)
(view all)		 101       RRPCEQISPEEEERR     dbPAF
183       EGAKEGDTGSTSGTS     dbPAF
191       GSTSGTSSPPAPCRP     dbPAF
217       LEPEALHTPTLMTTP     dbPAF
223       HTPTLMTTPSLTPFT     dbPAF
230       TPSLTPFTPSLVFTY     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource