| Tag | Content |
|---|---|
| UniProt Accession | EZRI_HUMAN; P15311; |
| Entrez ID | 7430 |
| GenBank Protein ID | NM_001111077.1; NM_003379.4; |
| GenBank Nucleotide ID | NP_001104547.1; NP_003370.2; |
| Protein Name | Ezrin (Cytovillin) (Villin-2) (p81) |
| Gene Name | EZR; VIL2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. |
| Sequence (Fasta) | MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK 60 LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE 120 TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR 180 GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF 240 PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI 300 EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK 360 AERELSEQIQ RALQLEEERK RAQEEAERLE ADRMAALRAK EELERQAVDQ IKSQEQLAAE 420 LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP 480 VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE AEKNERVQRQ LLTLSSELSQ 540 ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAL 587 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | NSCLC |
| CTD (Curated) (count: 7) (view all) | MESH:D002277
; Carcinoma MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D009362 ; Neoplasm Metastasis MESH:D010003 ; Osteoarthritis |
| GWASdb (count: 4) | rs3102970; Serum metabolites; Null
rs744893; Lipoprotein a [lp(a)] levels in plasma; atherosclerosis rs6455604; Type 2 diabetes; type 2 diabetes mellitus rs3127194; Serum metabolites; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 36) (view all) | 112 QVKEGILSDEIYCPP dbPAF
116 GILSDEIYCPPETAV dbPAF 137 VQAKFGDYNKEVHKS dbPAF 146 KEVHKSGYLSSERLI dbPAF 148 VHKSGYLSSERLIPQ dbPAF 149 HKSGYLSSERLIPQR dbPAF |
| Acetylation (count: 19) (view all) | 139 AKFGDYNKEVHKSGY PLMD
162 QRVMDQHKLTRDQWE PLMD 184 AEHRGMLKDNAMLEY PLMD 209 GINYFEIKNKKGTDL PLMD 237 KDDKLTPKIGFPWSE PLMD 253 RNISFNDKKFVIKPI PLMD |
| Ubiquitination (count: 38) (view all) | 139 AKFGDYNKEVHKSGY PLMD
143 DYNKEVHKSGYLSSE PLMD 162 QRVMDQHKLTRDQWE PLMD 184 AEHRGMLKDNAMLEY PLMD 209 GINYFEIKNKKGTDL PLMD 211 NYFEIKNKKGTDLWL PLMD |
| Glycation (count: 3) | 254 NISFNDKKFVIKPID PLMD
306 TIEVQQMKAQAREEK PLMD 83 LQFKFRAKFYPEDVA PLMD |
| Malonylation (count: 8) (view all) | 253 RNISFNDKKFVIKPI PLMD
254 NISFNDKKFVIKPID PLMD 262 FVIKPIDKKAPDFVF PLMD 263 VIKPIDKKAPDFVFY PLMD 296 ELYMRRRKPDTIEVQ PLMD 60 KGFPTWLKLDKKVSA PLMD |
| Succinylation (count: 1) | 60 KGFPTWLKLDKKVSA PLMD |