Tag | Content |
---|---|
UniProt Accession | PLAK_HUMAN; P14923; |
Entrez ID | 3728 |
GenBank Protein ID | NM_002230.2; NM_021991.2; XM_006721873.2; XM_006721874.2; XM_006721875.1; XM_006721878.1; XM_011524753.2; XM_011524755.1; XM_011524756.1; XM_011524757.2; XM_011524758.1; XM_017024590.1; |
GenBank Nucleotide ID | NP_002221.1; NP_068831.1; XP_006721936.1; XP_006721937.1; XP_006721938.1; XP_006721941.1; XP_011523055.1; XP_011523057.1; XP_011523058.1; XP_011523059.1; XP_011523060.1; XP_016880079.1; |
Protein Name | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) |
Gene Name | JUP; CTNNG; DP3 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). |
Sequence (Fasta) | MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG RQYTLKKTTT 60 YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQA TNLQRLAEPS 120 QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM 180 GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE 240 SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 300 ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH 360 LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC 420 NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY 480 GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR 540 HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 600 QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY 660 RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT YRPMYSSDVP LDPLEMHMDM 720 DGDYPIDTYS DGLRPPYPTA DHMLA 746 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 5) | MESH:C566925
; Arrhythmogenic Right Ventricular Dysplasia, Familial, 12 MESH:D008107 ; Liver Diseases MESH:C538346 ; Naxos disease MESH:D054318 ; No-Reflow Phenomenon MESH:D011471 ; Prostatic Neoplasms |
DisGeNet (Curated) (count: 41) (view all) | C0000887; Acantholysis
C0002170; Alopecia C0007193; Cardiomyopathy, Dilated C0008924; Cleft Lip C0011071; Sudden death C0012833; Dizziness |
GWASdb (count: 1) | rs11650969; Schizophrenia; schizophrenia |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 46) (view all) | 120 LQRLAEPSQLLKSAI dbPAF
125 EPSQLLKSAIVHLIN dbPAF 133 AIVHLINYQDDAELA dbPAF 14 MEQPIKVTEWQQTYT dbPAF 141 QDDAELATRALPELT dbPAF 160 DEDPVVVTKAAMIVN dbPAF |
Acetylation (count: 3) | 326 MRNYSYEKLLWTTSR PLMD
336 WTTSRVLKVLSVCPS PLMD 448 AILRAGDKDDITEPA PLMD |
Ubiquitination (count: 18) (view all) | 124 AEPSQLLKSAIVHLI PLMD
149 RALPELTKLLNDEDP PLMD 161 EDPVVVTKAAMIVNQ PLMD 171 MIVNQLSKKEASRRA PLMD 224 EGLLAIFKSGGIPAL PLMD 272 RLADGLQKMVPLLNK PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |