P14923

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PLAK_HUMAN; P14923;
Entrez ID 3728
GenBank Protein ID NM_002230.2; NM_021991.2; XM_006721873.2; XM_006721874.2; XM_006721875.1; XM_006721878.1; XM_011524753.2; XM_011524755.1; XM_011524756.1; XM_011524757.2; XM_011524758.1; XM_017024590.1;
GenBank Nucleotide ID NP_002221.1; NP_068831.1; XP_006721936.1; XP_006721937.1; XP_006721938.1; XP_006721941.1; XP_011523055.1; XP_011523057.1; XP_011523058.1; XP_011523059.1; XP_011523060.1; XP_016880079.1;
Protein Name Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene Name JUP; CTNNG; DP3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCommon junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Sequence
(Fasta)
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG RQYTLKKTTT 60
YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQA TNLQRLAEPS 120
QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM 180
GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE 240
SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 300
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH 360
LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC 420
NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY 480
GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR 540
HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 600
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY 660
RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT YRPMYSSDVP LDPLEMHMDM 720
DGDYPIDTYS DGLRPPYPTA DHMLA 746

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomaUY48024349301
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 5)
MESH:C566925 ; Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
MESH:D008107 ; Liver Diseases
MESH:C538346 ; Naxos disease
MESH:D054318 ; No-Reflow Phenomenon
MESH:D011471 ; Prostatic Neoplasms
DisGeNet (Curated)
(count: 41)
(view all)
C0000887; Acantholysis
C0002170; Alopecia
C0007193; Cardiomyopathy, Dilated
C0008924; Cleft Lip
C0011071; Sudden death
C0012833; Dizziness
GWASdb
(count: 1)
rs11650969; Schizophrenia; schizophrenia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 46)
(view all)
120       LQRLAEPSQLLKSAI     dbPAF
125       EPSQLLKSAIVHLIN     dbPAF
133       AIVHLINYQDDAELA     dbPAF
14        MEQPIKVTEWQQTYT     dbPAF
141       QDDAELATRALPELT     dbPAF
160       DEDPVVVTKAAMIVN     dbPAF
Acetylation
(count: 3)
326       MRNYSYEKLLWTTSR     PLMD
336       WTTSRVLKVLSVCPS     PLMD
448       AILRAGDKDDITEPA     PLMD
Ubiquitination
(count: 18)
(view all)
124       AEPSQLLKSAIVHLI     PLMD
149       RALPELTKLLNDEDP     PLMD
161       EDPVVVTKAAMIVNQ     PLMD
171       MIVNQLSKKEASRRA     PLMD
224       EGLLAIFKSGGIPAL     PLMD
272       RLADGLQKMVPLLNK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource